The invention discloses a waste gas oxidation treatment system which comprises an ozone generator. A demisting layer, a spray layer, a packing layer and an aeration layer are arranged in an oxidation spray tower from top to bottom, the aeration layer consists of a plurality of aeration disks, an ozone outlet of the ozone generator is communicated with the aeration layer in the oxidation spray tower, a plurality of packing layers are arranged in a catalytic oxidation tower, main packing includes catalysts, and a demisting layer, a spray layer and a packing layer are arranged in an acid-base neutralization tower from top to bottom. Compared with the prior art, the waste gas oxidation treatment system is more thorough in waste gas treatment, better in effect and lower in cost.