The invention discloses an epitaxial lead strontium titanate film with a lithium nickelate buffer layer and a preparation method. A layer of buffer layer conductive electrode LNO film is deposited on one side of the MgO substrate, and a perovskite phase PST film is deposited on the buffer layer conductive electrode LNO film. The steps are as follows: firstly, using lithium carbonate, nickel oxide, lead carbonate, strontium carbonate and titanium oxide as raw materials, respectively preparing lithium nickelate target material and strontium lead titanate target material by solid-phase sintering method; secondly, using (001) MgO substrate After cleaning, it was put into the reaction chamber, the reaction chamber was evacuated, and the substrate was heated. Oxygen was used as a protective gas, introduced into the reaction chamber, and the target was sputtered by pulsed laser, and the lithium nickelate buffer layer and strontium lead titanate were epitaxially deposited on the substrate successively. film. The preparation method of the invention is simple, the prepared strontium lead titanate thin film has good epitaxy and high quality, and the dielectric adjustability of the thin film can reach 40% to 70%.