The invention discloses a waterproof shoe material and a preparation method thereof. The waterproof shoe materials is prepared from the following components: a styrenic thermoplastic elastomer, polyurethane resin, polystyrene, glass fibers, white mineral oil, nanosized silica, methyl parahydroxybenzoats, phenylcarbinol, liquid paraffin, a silane coupling agent, a plasticizer and an anti-granule agent. According to the preparation method of the waterproof shoe material, disclosed by the invention, by interacting raw materials with ingredients and utilizing unique properties of the materials andsynergy among all the materials, the waterproof shoe material is prepared. The problems of simple functions, complex production process, more material consumption and time consumption, high labor cost and high production cost of current shoe materials are improved in a targeted manner; in addition, the waterproof shoe material disclosed by the invention has a special waterproof effect and the problem of a traditional shoe preparation process can be changed; meanwhile, wear resistance of the shoe material is improved; the waterproof shoe material has the advantages of light texture, full toughness, convenience for slip resistance, cold resistance and tear resistance; besides, the preparation process of the waterproof shoe material is simple and reasonable and can be widely applied.