The invention provides an ore granulation device and method with adjustable inclination angle and rotational speed, belonging to the technical field of metal ore granulation. The device includes a granulation drum, a partition, a fixed knob, a trapezoidal keel, a rotating support platform, an angle scale, an angle adjustment bracket, an angle adjustment knob, a threaded screw, a main rotating roller, a slave rotating roller, a variable speed motor, a motor bracket, and a transmission devices, stainless steel brackets, leveling nuts, etc. Rotate the threaded screw to open and close the angle adjustment bracket, use the angle scale to observe and determine the current inclination angle, and realize the adjustable inclination angle of the granulation drum; the variable speed motor is connected with the lateral support roller through the transmission system to drive the granulation drum to rotate ; There is a keel inside the granulation drum to improve the efficiency of granulation rolling and granulation; there is an axial support roller inside the rolling guide to ensure that the granulation drum does not move axially during rotation. The structure of the device is simple, the method is practical and convenient, and it can carry out high-efficiency granulation of ore under actual working conditions such as different inclination angles and different speeds.