The invention relates to intelligent sealing equipment which comprises a base, a guide rod, a tray, a hobbing cutter, a rotary shaft and a drive device. The base further comprises a pressure head replacing device. The pressure head replacing device comprises a pressing head, a lifting mechanism, a pushing mechanism, a conveying mechanism and a fixing mechanism. The lifting mechanism comprises a first motor, a lead screw, a sliding rod and a sliding block. The pushing mechanism comprises an air cylinder and a pushing plate. The conveying mechanism comprises a second motor, a driving wheel, a driven wheel and a belt. The fixing mechanism comprises a plurality of fixing assemblies. Each fixing assembly comprises an electromagnet, a spring, an iron block and a limiting rod. According to the intelligent sealing equipment, the pressure head replacing device is arranged, a pressure head can be replaced automatically by starting the pressure head replacing device when the intelligent sealing equipment needs to seal packaging containers of other calibers, and compared with manual operation, time and labor are saved, the labor intensity is relieved, and the production efficiency is not affected.