121results about How to "Achieve escape" patented technology

The invention discloses an oil-in-water emulsion free of surfactant. The emulsion comprises a metabolizable oil phase, a water phase and oil-water amphipathic solid particles dispersed in the water phase and having biocompatibility, wherein the oil phase comprises squalene or / and tocol; the water phase is any one or a combination of at least two of purified water, water for injection, aqueous liquid of glycerol, buffered saline liquid and clinically available infusion liquid; and the average grain diameter of the solid particles is at nanometer-to-micron grade. The emulsion can be used as a vaccine adjuvant or a medicine delivery or controlled release carrier; the properties of the emulsion can be controlled and regulated; the obtained emulsion is stable; the use of a surfactant is avoided; and harm to the human body and pollution on the environmental can be reduced.

The invention discloses a compound with anthrone as a core and a use thereof. According to the compound, anthrone is a mother nucleus and is connected to an aromatic heterocyclic group so that molecular symmetry is destroyed, molecule crystallinity is destroyed, intermolecular aggregation is avoided and good film-forming performances are obtained. The compound as a light-emitting layer material is used for an organic light-emitting diode. An OLED device prepared from the compound has good photoelectric properties and can satisfy the requirements of the panel manufacturing companies.

The invention discloses a compound containing ketone and heterocyclic nitrogen and application thereof to an organic light-emitting device. The compound has the advantages of being not subjected to crystallization and aggregation easily and having good film-forming property, and rigid groups in molecules can improve heat stability of a material. The compound serving as a light-emitting layer material is applied to an organic light-emitting diode (OLED), and a manufactured OLED device has good photoelectric property and can meet the requirements of panel manufacturing enterprises.

The invention relates to a boron-containing organic compound and application of the boron-containing organic compound to an OLED device. The structure of the compound is shown as a general formula (1), the whole molecule of the compound is a large rigid structure, and the introduction of substituent groups reduces the planarity of a material, so the steric hindrance of the material is increased, the material is not easy to rotate, and a three-dimensional space structure is more stable; and therefore, the compound has higher glass transition temperature and molecular thermal stability. In addition, the HOMO and LUMO distribution positions of the compound are separated from each other, so the compound has appropriate HOMO and LUMO energy levels; and therefore, after the compound is applied to the OLED device, the luminous efficiency of the device can be effectively improved, and the service life of the device can be effectively prolonged.

The invention discloses a programmed multi-target tree-shaped macromolecular assembled body medicine conveying system as well as a preparation method and application thereof and belongs to the field of biomedical materials. The medicine conveying system taking an amphipathic tree-shaped macromolecular assembled body as a carrier is used for realizing programmed multi-target through responding a tumor micro-environment, so that main biological obstacles met in a process of transferring the medicine carrier in a body are overcome, and finally, medicines are conveyed to the destination. The obtained self-assembled body has a multi-target effect through the functionalization effect of a plurality of types of terminal groups. On one hand, tree-shaped molecules are used as the medicine carrier and have the advantages of good stability, high mechanical strength, multivalent terminal groups, hyper-branched structures, and intracellular conveying of echoviruses; on the other hand, a multi-element cooperated self-assembling policy is integrated with the advantages of all functional groups on a tree-shaped macromolecular self-assembled unit, so that the assembled body can be conveyed by the multifunctional and efficient medicine system. The system is particularly suitable for conveying anti-tumor medicines.

The invention relates to the field of accessories and preparations with medicinal functions, in particular to a kind of oligopeptide-based pH-sensitive amphoteric ion lipid (I) or (II). In the invention, the derivatives of the oligopeptide amphoteric ion lipid have different surface charges under different pH conditions and can take relatively strong negative charges in a physiological environment with pH near neutrality so that the lipid has good blood compatibility; when the lipid reaches a tumor part, the surface charges of the oligopeptide amphoteric ion lipid are reversed in an acidulous tumor environment, so that the original electronegativity is reversed into electropositivity; and a carrier with positive charges is easily combined with the surface of a tumor cell, and the tumor cell targeting can be effectively realized through an endocytosis path. In lysosome, a cationic carrier continuously realizes a function of proton sponge or a function of splitting lysosome membranes, and the two functions can ensure the integrity of the carrier, so that the carrier can safely escape to cytoplast or other organelles.

The invention discloses a compound taking anthrone as a core and an application of the compound in an OLED device. The compound takes anthrone as a parent core, which is connected with a heterocyclic aromatic group to destroy molecular symmetry, so that molecular crystallinity is destroyed, aggregation effect among the molecules can be avoided, and the compound has good film forming ability. The compound as a luminescent layer material is used on an organic light-emitting diode, the OLED device using the compound has good photoelectric performance, so that the requirement by a panel manufacture enterprise can be satisfied.

The invention relates to a boron-containing organic compound and application thereof to an organic light-emitting device, belonging to the technical field of semiconductors. The structure of the boron-containing organic compound is shown as a general formula (1). The invention also discloses the application of the boron-containing organic compound in an organic electroluminescent device. Accordingto the boron-containing organic compound, the whole molecule of the compound is of a large rigid structure, the planarity of a material is reduced through introduction of substituent groups, the steric hindrance of the material is increased, the material is not prone to rotation, a three-dimensional space structure is more stable, and therefore, the compound has high glass transition temperatureand molecular thermal stability; in addition, the HOMO and LUMO distribution positions of the compound are separated from each other, so the compound has appropriate HOMO and LUMO energy levels. Therefore, after the compound is applied to the OLED device, the luminous efficiency of the device can be effectively improved, and the service life of the device can be effectively prolonged.

The invention relates to a DCs vaccine based on phospholipid hybrid polymersome jointly encapsulating an antigen and dual immunoagonists, a preparation method and application thereof. The phospholipidhybrid polymersome which can jointly load a model antigen OVA and two types of TLR agonists (TLR7 / 8 and TLR4) is used for stimulation in vitro of the DCs so as to realize the effective phagocytosis of DCs cells. The rapid and long-term immunostimulatory effect on the DCs is achieved by the internal and external co-loading of the OVA antigen. The synergistic effect of the two types of TLR agonistssignificantly enhances the immune response after antigen stimulation; the phospholipid hybrid polymersome which jointly encapsulates the antigen and the dual immunoagonists can effectively promote the activation and maturation of the DCs, increases the level of cross-presentation, promotes the migration of the DC vaccine to secondary lymphoid organs, and produces a strong specific cytotoxic T lymphocytes (CTLs) killing effect, thereby effectively killing tumor cells and realizing the immunotherapy of the DCs vaccine on tumors.

The invention discloses a boron-containing multi-element heterocyclic organic compound and an application thereof to an OLED (organic light-emitting diode) device. The compound utilizes benzo six-membered rings as a core, and boron is located on the six-membered ring in the center. The compound has the characteristics that molecules are not prone to crystallization and aggregation and film-formingproperty is good. When the compound is utilized as a luminous layer material of the OLED device, current efficiency, power efficiency and external quantum efficiency of the device are greatly improved; besides, the service life of the device is obviously prolonged.

The invention relates to PH-sensitive targeted LPNs (lipid poly-L-histidine hybrid nanoparticles) for encapsulating anti-tumor drugs. The LPNs comprise raw materials in percentage by mass as follows:50%-80% of PHIS (poly-histidine) and 20%-50% of lipid (including lipid-PEG), wherein the lipid PEG accounts for 1%-100% of the total mass of lipid. A hydrophobic core consists of PHIS, and the surfaceis modified with polyethylene glycol and tumor targeted peptide. The PEGylated lipid surface has the characteristics of good biocompatibility, high stability and long in-vivo circulation. A histidinecore can encapsulate the hydrophobic anti-cancer drugs under the neutral condition, histidine is protonized in the tumor microenvironment to mediate the carrier potential to change from negative to near neutral, intake and endocytosis of a carrier arepromoted, the carrier mediates the lysosome to escape after endocytosis, the drugs are released rapidly, tumor cells are effectively killed, and accordingly, the problems that the PEGylated nano-carrier endocytosis efficiency is low and cannot release the drugs in cells effectively after endocytosis are solved. The surface of the carrier can bemodified with a tumor-specific antibody or ligand, the tumor targeting property is further improved, and the therapeutic effect is improved.

The invention discloses an organic compound taking pyridine as a core and application thereof to OLED. The organic compound has the characteristics that the molecules are not easy to crystallize and aggregate, and have good film-forming property. The rigid group in the compound molecule can improve the heat stability of materials. When the compound serving as a luminescent layer material is applied to OLED, manufactured OLED devices have good photoelectric property and can properly meet the requirements of panel manufacturing enterprises.

The present invention discloses an organic compound with a ketone structure as a mother nucleus and application thereof in an organic electroluminescent device, the organic compound has the characteristics that Delta Est< 0.2 eV, and a 2.7 eV< T1< 3.0 eV, the organic compound is connected with aromatic heterocyclic groups for destruction of molecular symmetry, molecular crystallinity is destructed, intermolecular aggregation can be avoided, and the organic compound has good film-forming properties. When the organic compound is used as an emitting layer material of an organic light-emitting diode, the OLED device using the compound has good photoelectric properties and can meet the requirements of panel manufacturing enterprises.

The invention relates to the technical field of medicines, and particularly relates to a peptide-modified multi-walled carbon nanotube carrier as well as a preparation method and application thereof. The invention provides the peptide-modified multi-walled carbon nanotube carrier which is formed by a nano-carrier MHR of a multi-walled carbon nanotube modified by short peptide composed of three arginines and six histidines. The nano-carrier provided by the invention can enhance solubility and dispersibility of carbon nanotubes in an aqueous solution, and reduce biological organism toxicity of the multi-walled carbon nanotubes; the prepared nano-carrier forms an MHR-CPG nano immune-activator by electrostatic adsorption of negatively charged immune-activator CpGDNA and the like; the nano-carrier provided by the invention can use MHR-CPG to stimulate the anti-tumor immune efficacy of the body, opens up a new treatment strategy for treatment of patients with prostate cancer, and also provides new theoretical basis and ideas for application of carbon nanotubes in drug carriers.

The invention discloses a compound taking anthranone as a core and an application of the compound in organic electroluminescent devices. The compound has the characteristics that molecules are not prone to crystallization and not prone to aggregation and the film forming property is good, and the thermal stability of the material can be improved due to rigid radicals in the molecules. The compound disclosed by the invention is applied to the organic electroluminescent devices as a luminescent layer material, and manufactured organic electroluminescent devices have good photoelectric properties and can meet the requirements of panel manufacturing enterprises.

The invention discloses a pyridine-based five-membered-ring substituted compound and application thereof. The compound provided by the invention has the characteristics that the crystallization and the aggregation among molecules are difficult, and the compound has a favorable film-forming property. The heat stability of a material can be improved by rigid groups in the molecules of the compound provided by the invention; the compound provided by the invention is applied to OLEDs (Organic Light Emission Diodes) as a luminescent layer material; a made OLED appliance has favorable photoelectric properties, and can better meet the requirements of a panel manufacturing enterprise.

The invention discloses a compound adopting dimethylanthrone as a core, and an application thereof in organic electroluminescent devices. The compound adopting the dimethylanthrone as the core and heteroarylcarbazole as a branched chain has the characteristics of difficulty in intermolecular crystallization, difficulty in aggregation and good electrochemical stability. When the compound is used as the luminescent layer material of the organic electroluminescent devices, the current efficiency of the devices is greatly improved, and the life of the devices is obviously prolonged.

The invention discloses an organic electroluminescence compound with nitrogen-containing five-membered heterocycle as the core and application thereof. The compound has the nitrogen-containing five-membered heterocycle as the core, is not easy to crystallize between molecules and is not easy to aggregate, and has good film forming ability. The compound, used as a luminescent layer material, is applied to organic electroluminescent devices. An organic electroluminescent device by using the compound has good photoelectric property and can better meet application requirements of panel manufacturing enterprises.

The invention relates to an organic compound taking diboron as a core, a preparation method of the organic compound and application of the organic compound to an organic light-emitting device. The structure of the compound is shown as a general formula (1); the whole molecule of the organic compound with diboron as the core is of a large rigid structure, the introduction of branched chains reducesthe planarity of the material, the steric hindrance of the material is increased, the material is not easy to rotate, and the three-dimensional space structure is more stable, so that the compound has high glass transition temperature and molecular thermal stability; in addition, HOMO and LUMO distribution positions of the compound are separated from each other, so that the compound has appropriate HOMO and LUMO energy levels; therefore, after the compound is applied to the OLED device, the luminous efficiency of the device can be effectively improved, and the service life of the device can be effectively prolonged.

The invention discloses a boron-containing organic electroluminescent compound and an application thereof on organic electroluminescent devices, and belongs to the technical field of semiconductors. The boron-containing organic electroluminescent compound has a structure shown in a general formula (1). The invention also discloses an application of the boron-containing organic electroluminescent compound on organic electroluminescent devices. When the compound is used as a luminescent layer material of an organic electroluminescent device, the current efficiency, the power efficiency and the external quantum efficiency of the device are greatly improved; and meanwhile, the service life of the device is obviously prolonged.

The invention discloses a 9,10-anthraquinone based compound and an application thereof in organic electroluminescent devices. According to the compound disclosed by the invention, 9,10-anthraquinone serves as a parent core, two sides are connected with two aromatic heterocyclic groups, thus, the crystallinity of molecules is destroyed, the aggregation of the molecules is avoided, and the film forming property is good; and the compound disclosed by the invention is applied to the organic electroluminescent devices as a luminescent layer material, and the organic electroluminescent devices using the compound disclosed by the invention have good photoelectric properties and can better adapt to and meet the application requirements of panel manufacturing enterprises.

The invention relates to a culture wastewater efficient degrading and denitrifying treatment system and a treatment method thereof. The system comprises, sequentially connected, an equalizing basin, a sand precipitation basin, a feeding basin, an anaerobic reactor, a preoxidation-nitrosation integration basin, an anaerobic ammoxidation reactor and an outlet water return basin, the anaerobic reactor is an anaerobic internal circulation reactor, wastewater flows through an external circular basin cavity and then enters an internal circular basin cavity, the anaerobic ammoxidation reactor is an upflow anaerobic packed tower, culture wastewater goes through above structures to sequentially undergo purifying reactions comprising hydrolysis, sand removal, anaerobic treatment, nitrosation and anaerobic ammoxidation, and harmful pollutants can be efficiently removed through multi-grade degrading treatment. The method combines an anaerobic process with an anaerobic ammoxidation process, and allows COD to be removed through the anaerobic process and nitrogen to be removed through the anaerobic ammoxidation process, so efficient removal of high-concentration pollution components in the culture wastewater is realized, and the method is simple to operate and stably runs.

The invention discloses a ketone structure-cored organic compound and application thereof to organic light emitting devices. The ketone structure-cored organic compound is characterized in that deltaEst<0.2eV, and 2.7 eV<T1<3.0 eV; when connected with heteroaromatic groups, the ketone structure-cored organic compound can break molecular symmetry to break molecular crystallization property, avoidintermolecular aggregation and accordingly achieve good film-forming performance. The ketone structure-cored organic compound can be applied to organic light emitting diodes as a luminescent layer material; OLED devices with the ketone structure-cored organic compound can achieve high photoelectric properties and meet the demands of panel manufacturers.

The invention discloses a boron-containing organic compound and an application thereof in an organic electroluminescent device. The compound takes a benzo five-membered ring as a core, and a boron element is located on a central five-membered ring; and the intermolecular crystallization and aggregation of the compound are not easy, and the compound has good film-forming abilities. When the compound is used as the luminescent layer material of an organic electroluminescent device, the current efficiency, power efficiency and external quantum efficiency of the device can be greatly improved; andthe service life of the device can be obviously prolonged as well.

The invention provides a method for preparing high-purity graphene. The method comprises the following steps: (1) respectively grinding and screening graphite to obtain graphite powder having an average grain diameter of 210-480mu m; (2) weighing the graphite powder and an oxalic acid solution in a weight ratio of 1:1.5-1:5 to prepare a carboxylated graphene turbid solution; (3) putting the carboxylated graphene turbid solution in an ultrasonic device for ultrasonic oscillation to obtain a carboxylated graphene suspension; (4) adding a zinc salt solution into the carboxylated graphene suspension, and stirring to obtain a mixed solution of zinc salt and carboxylated graphene; filtering the mixed solution, carrying out microwave heating and activating treatment on the filtered substances, cooling, pickling, washing, filtering and drying to obtain graphene. The method is low in material cost, simple in manufacture process and convenient for large-scale production, and the prepared graphene has a relatively high specific surface area.

The invention discloses a boron-containing five-membered heterocyclic compound and an application thereof to an organic light-emitting device. The compound takes a benzo five-membered ring as a core,boron is positioned at the center five-membered ring, and the compound has the advantages that molecules are not easily crystallized or gathered, and the compound has a good film-forming property. When the compound is used as a luminous layer material of the organic light-emitting device, the current efficiency, the power efficiency and the external quantum efficiency of the device can be greatlyimproved, and the service life of the device is obviously prolonged.

The invention discloses a boron-containing six-membered heterocyclic derivative and an application thereof to an organic light-emitting device. The derivative takes a benzo five-membered ring as a core, boron is positioned at the center five-membered ring, and the derivative has the advantages that molecules are not easily crystallized or gathered, and the derivative has a good film-forming property. When the derivative is used as a luminous layer material of the organic light-emitting device, the current efficiency, the power efficiency and the external quantum efficiency of the device can begreatly improved, and the service life of the device is obviously prolonged.

The invention discloses a compound with acridone as the core and application of the compound to an organic electroluminescent device. The compound has acridone as the core, is not easy to crystallize between molecules and is not easy to aggregate, and has good film forming ability. When the compound is used as a luminescent layer material of an OLED luminescent device, current efficiency, power efficiency and external quantum efficiency of the device are all greatly improved. Meanwhile, life of the device is obviously prolonged.