32 results about "Urine iodine" patented technology

The present invention relates to a urine iodine determination kit. It includes urine purification device, diluent liquor, color-developing liquor, composite oxidant and standard colorimetric plate. Said kit can quickly remove interference substance from the urine, and can be used for accurately determining iodine concentration in the urine. The above-mentioned urine purification device is a titration type container in which a selective specific adsorbent for specifically adsorbing interference substance in the urine is held. Said selective specific adsorbent is made up by using purification active carbon and iodine adsorption agonist NaCl, MgCl2 or NaBr through baking activation process, the above-mentioned color-developing liquor is a mixed reagent formed from tetramethylbenzidine aqueous solution and polyethylene glycol. Besides, said invention also provides the composition of the composite oxidant.

The invention discloses a method and device for detecting urine iodine concentration. The method comprises the steps of parameter setting, image acquisition, reaction time calculation and urine iodine concentration calculation. According to the method and the device, a computer is used for controlling a camera to acquire reaction images of a urine iodine sample added into a reaction reagent, data analysis is performed on color changes of the acquired reaction images so as to judge the reaction time, and the urine iodine concentration is calculated according to the reaction time. The method and the device can be widely applied in the field of medical detection.

The present invention discloses a urine iodine determination kit. According to the kit, based on the adsorbent, the dilution liquid, the coloring agent and the standard substance of the existing kit, a hydrogen peroxide solution, peroxyacetic acid solution, sodium hypochlorite solution or potassium permanganate solution with a mass percentage concentration of 5-12% is selected as an oxidizing agent and a special terminating liquid is arranged, and the terminating liquid comprises a sulfuric acid solution, hydrochloric acid solution, citric acid solution, sodium fluoride solution, sodium azide solution or potassium iodate solution with a mass percentage concentration of 1-20% or a combination comprising any solutions selected from the sulfuric acid solution, the hydrochloric acid solution, the citric acid solution, the sodium fluoride solution, the sodium azide solution and the potassium iodate solution according to any mass percentage ratio. According to the present invention, the single adsorbent and the single oxidizing agent are used so as to significantly reduce the cost, and the terminating liquid is used to rapidly terminate the reaction, such that it is ensured that the color is not significantly changed within a certain time, and the stable detection result coloring and the accurate detection result interpretation are achieved.

The invention discloses an iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and an iodide ion detection method. In an acid medium, a tetravalent cerium solution or potassium permanganate solution is used for oxidizing an orange red Ferroin reagent solution into a blue solution in an acid medium, and a hydrazine saline solution is added to enable the blue solution to generate a reaction that blue is slowly faded to be turned into orange red; iodine has a sensitive oxidizing effect for the reaction, the higher the iodine concentration is, the higher thereaction speed is, a proportional relation is formed between the iodine concentration and the luminance value, and the iodine content of a sample can be calculated by an iodine standard curve. The detection result can be consistent to the result of the iodine tested by adopting a classical arsenic-cerium catalytic photometric method, and the use of a virulent hard-to-purchase arsenic trioxide reagent in the classical arsenic-cerium catalytic photometric method is avoided. The detection method has the advantages of being simple and convenient, rapid, specific, sensitive, accurate and the like,is expected to be widely applied to related fields needing to detect the iodine content of the sample, and especially is applied to urine iodine and water iodine detection in the fields of sanitary inspection and medical technology.

The invention relates to a full-automatic intelligent urine iodine analyzer, which comprises a shell, a sample carrier mechanism, a reagent liquid adding device, a light path detection system, a comprehensive sample processing mechanism, a waste trough and an electric control system. By adoption of a quantitative colorimetric method, point-to-point operation of various reagents is realized throughcontrol of reagent disc rotation; by adoption of a sample adding stirring device, mixing of to-be-tested reagents is realized, cross contamination of samples is avoided, and mixing efficiency is improved; by a double-reagent-needle sample adding arm, a color developing agent and an oxidant adding function is realized, detection time is shortened, and internal and external spaces of equipment aresaved; functions of automatic result interpretation and automatic report printing are achieved, urine iodine detection automation is improved, errors caused by manual sample adding are effectively avoided, urinalysis detection precision and detection efficiency are improved, and detection cost is reduced.

The invention relates to a method for quickly and quantitatively measuring urine iodine. The method comprises the steps of: adopting polypropylene microwell plates with good heat resistance and chemical inertness as a digestion container and catalytic reaction container; preventing cross contamination of samples and water vapor leakage from the microwell plate by using a self-made sealing plate; and simultaneously measuring light absorbance of a plurality of samples at the same time by using an ELIASA reader. The method realizes batch measurement of micro samples. According to the method provided by the invention, the usage amount of reagents is greatly reduced, the measuring time is greatly shortened, and the workload in a measuring process is reduced, so that the method is suitable for measuring a large batch of samples. The method of the invention requires only simple instrument, and is low in analysis cost. The analysis efficiency is a little higher than that of an automatic analysis method.

The invention relates to a detection method of iodine ions in urine based on alcohol solvent-induced silver nanocluster fluorescence enhancement. The detection method comprises the following steps: adopting a biomineralization way to prepare a material with silver nanoclusters firstly, changing selective recognition and response performance of the silver nanoclusters to anions by utilizing alcohol solvent induction to form an alcohol-induced fluorescence enhanced silver nanocluster probe, and establishing a simple, convenient, rapid, specific, sensitive and visual iodine ion fluorescence detection method to realize specific fast detection of the iodine ions in a complex human excrement sample such as the urine. A detection result is comparable to that of a typical instrument detection method, the urine iodine detection process does not involve complex instrument operation, and the detection method has the advantages of simpleness, convenience, rapidness, specificity, high sensitivity, visualization and the like and is expected to be widely applied to the biological and medical monitoring and detection field.

The invention discloses an iodide ion detection kit based on iodine catalyzed arsenic-cerium reaction under the acidic condition and taking a Ferrion solution as a redox indicator. The kit comprises adigestion solution, a reducing agent, an oxidizing agent and an indicator; an ammonium persulfate or acidic potassium permanganate solution serves as the digestion solution; the arsenious acid solution serves as the reducing agent; a tetravalent cerium solution serves as the oxidizing agent; and a Ferroin reagent solution serves as the indicator. An iodine standard series solution is prepared, and the ammonium persulfate or acidic potassium permanganate solution is used as the digestion solution, so that the defects of dense smoke and explosiveness of chloric acid digestion are overcome. Thedetection kit also has the advantages of being simple, rapid, specified, sensitive and accurate, can be widely applied to the fields in which the content of iodide needs to be detected, and in particular, to urine iodine and water iodine detection in the fields of hygiene inspection and medical inspection.

The invention discloses a kit for determining urine iodine. The kit comprises double-liquid components reagents R1 and R2 which are independent mutually, wherein the reagent R1 is prepared from 20-180mmol / L of Tris buffer solution, 10-30 g / L of NaCl, 2-30 g / L of Sb2O3, 2.0-3.0 mol / L of H2SO4 and a solvent purified water, and the reagent R2 is prepared from 20-180 mmol / L of Tris buffer solution, 20-40 g / L of ammonium cerous sulfate, 2.0-3.0 mol / L of H2SO4 and a solvent purified water. The invention also discloses a preparation and use method of the kit for determining urine iodine. The kit hasthe advantages that urine does not need digestive treatment, and experimental steps are simplified; only 10 minutes are needed for detection, the reaction time is greatly compressed; the kit is suitable for full-automatic testing.

The invention discloses an iodine nutrition level individualization evaluation method and application. The method comprises the steps that (1) individual salt intake is acquired through a 3-day salt weighing method; (2) the salt iodine content is determined and the step (1) is combined to acquire individual salt iodine intake; (3) individual diet iodine intake is acquired; and (4) the reference intake of iodine diet is compared with the individual diet iodine intake in the step (3) to evaluate the individual iodine level. In the step (3), the individual salt intake and the individual salt iodine intake in the steps (1) and (2) are substituted into the formula individual diet iodine intake=daily salt intake*salt iodine content*(1-salt iodine cooking loss ratio (L)) / proportional coefficient(F), wherein L is 24.6%; F is equal to 0.65 to 0.85, and is acquired from individual salt iodine intake (S) / individual total iodine intake (D); S is acquired similar to the steps (1) and (2); and D isacquired by measuring 24-hour urine iodine repeatedly. The method provided by the invention can be used to calculate and evaluate individual daily iodine level, solves the problem of inadequate individual iodine evaluation methods, has good application and operability, and has a clinic guiding significance.

The invention discloses a quantitative analysis system for urine iodine. The quantitative analysis system comprises a dropping bottle with urine filtering and purifying function, an extruding device for extruding urine in the dropping bottle to a test tube, a detection reagent for in-vitro detection of urine iodine content as well as a quantitative analyzer for in-vitro detection of urine iodine content in the detection reagent in the test tube. With adoption of the scheme, in-vitro detection has higher reproducibility and accuracy degree, the color developing gradient and color developing stability are quite good, the system is simple to use and operate, reaction detection consumes a little time, and too much processing of a urine sample is not needed; the system is simple, fast, high in accuracy and sensitivity, contains no heavy metal compounds or aldehyde condensation compounds, cannot cause environmental pollution and is safe and environment-friendly; detection results are used for evaluating iodine nutritional status of detected crowds and is suitable for being popularized and applied in primary health care institutions with severe iodine deficiency.

The invention discloses a urine iodine analyzer. The urine iodine analyzer comprises a casing, a mixing mechanism, a detecting mechanism and a control unit, wherein a first clamp groove is formed in one side wall of the casing, a cuvette is detachably buckled in the first clamp groove, and coaxial detecting holes are formed in two opposite side walls in the first clamp groove; the mixing mechanismis used for driving to-be-detected urine and a chemical reagent in the cuvette to be mixed uniformly; the detecting mechanism is arranged in the casing and used for detecting and analyzing the to-be-detected urine in the cuvette. The urine iodine analyzer provided in the technical scheme is simple in structure, convenient to use and low in cost, is particularly applicable to families or communitycenters and other places and detects and analyzes iodine content of the urine, detection and analysis results can be used for evaluating iodine nutritional status of detected crowds, the urine and the chemical reagent in the cuvette can be mixed rapidly and sufficiently for a reaction by the mixing mechanism, and the problem that detection precision is affected by spill of liquid out of the cuvette due to mechanical stirring or hand shaking is solved.

The invention discloses a full-automatic urine iodine and water iodine analyzer and analysis method. The full-automatic urine iodine and water iodine analyzer comprises an analyzer body, and the analyzer body comprises a workbench, and a three-dimensional motion platform, a graphite digestion device, a water bath container, a sample holder, a stirrer, a cleaning device and a detection device whichare arranged on the workbench. The full-automatic urine iodine and water iodine analyzer disclosed by the invention can realize full-automatic digestion, full-automatic reagent adding and quick full-automatic detection of samples, is high in automation degree and high in working efficiency, and meets the requirements of customers on quick analysis.

The invention discloses a full-automatic urine iodine and blood iodine detection machine and an automatic detection method thereof. A cuvette transmission device, an automatic gun head dismounting device, an automatic gun head racking device and an automatic sorting device are utilized, automatic sorting racking and dismounting of gun heads and cuvettes can be achieved by combining a transfer device, full-automatic batch processing is achieved in the whole detection process, manual interference is not needed, use is convenient and fast, and efficiency is high.

A classic trace iodine detection method is an arsenic-cerium catalytic spectrophotometric method, such as a sanitary industry standard method WS / T 107-2016 for urine iodine detection, and is widely applied to iodine deficiency and iodine nutrition monitoring in China. However, a highly toxic arsenic trioxide (arsenic trioxide) reagent needs to be used in the method, and the application of the method is increasingly limited due to environmental protection. A non-toxic trace iodine detection reagent and a non-toxic trace iodine detection method are urgently needed in the field of health care. The invention discloses a reagent and a method for detecting iodide ions by adopting an iodine catalyzed antimony-cerium redox reaction principle. Iodine ions catalyze Sb < 3 + > to reduce yellow Ce < 4+ > into colorless Ce < 3 + >, and the reaction speed and the iodine content are in a positive correlation quantitative relation. And after a certain reaction time, the absorbance of the residual Ce< 4 + > in the solution is measured by using a spectrophotometric method, and the iodine content of the measured sample is calculated according to the quantitative relationship between the iodine content and the absorbance. According to the method, toxic-free antimony is adopted to replace highly-toxic arsenic in a classic method, the detection effect consistent with that of an arsenic-cerium catalytic spectrophotometry is achieved, the highly-toxic arsenic trioxide reagent is prevented from being used, and the method is applied to detection of urine iodine, blood iodine, water iodine, salt iodine, food iodine, soil iodine and the like and has important public health significance.

The invention discloses a salt iodized-content adjusting method. In the state of unchanging the iodized salt intaking of the crowd at a local area, the salt iodized-content adjusting method sequentially comprises the following steps of (1) obtaining the urine-iodine median of the crowd at the local area through monitoring; (2) obtaining the 24-hour urine amount of the crowd at the local area through monitoring, and obtaining the daily iodine-intaking amount of the crowd at the local area by combing the step (1); (3) measuring the at-home salt-iodine content of residents in the crowd at the local area, simultaneously collecting the daily salt amount of the residents, and calculating the supplied iodine content of iodized salt; (4) deducting the supplied iodine content of the iodized salt from the daily iodine-intaking amount of the crowd at the local area to obtain the EIR (Environmental Iodine Resource) average value of the crowd at the local area at the time period, and then judging the iodine nutrient level of the crowd under a condition without eating the iodized salt according to the daily recommended iodine-intaking amount of an international organization; (5) determining the suitable salt iodized content of different crowds by combining EIRs with the daily iodine-intaking amount target value of the crowd at the local area and the salt eating amount of the crowd at the local area. Practical situations can be reflected by results, and the salt iodized-content adjusting method has the advantages of wide application and simplicity in operation.

The invention discloses a method for preparing an iodine ion selective electrode crystal film by employing a high-temperature melting method. The method comprises the following steps: melting silver iodide (AgI) at high temperature, adding silver sulfide with a certain ratio (Ag2S) for performing high-temperature sulfuration reaction on the AgI, so that the AgI is separated from impurities, the ductility or the toughness of the AgI is enhanced, the problems that an iodine ion selective electrode of a crystal film prepared by using a powder compaction method is low in selectivity coefficient and low in interference resistance, gaps and cracks are generated in the crystal film and the like are solved, the selectivity coefficient of iodine ions on chloride ions is 10<-6> to 10<-7>, other impurities in a urine sample do not interfere the test, and the crystal film can be directly used for testing human urine iodine.

The invention discloses a urine iodine quantitative detection device and a urine iodine quantitative detection method, belongs to the field of quantitative detection, and relates to an instrument device for performing color recognition on a reaction solution by utilizing a color recognition technology and determining the concentration of urine iodine to be detected. The device is composed of an LED light source module, a color sensor, a communication module, a stepping motor, a temperature measurement module, a microprocessor and other main parts. Aiming at the defects of expensive price and complex operation of a traditional large detection instrument, the invention develops a detection device which is simple to operate, low in cost and high in automation degree. By quantitatively detecting the concentration of iodide ions in urine, primary screening of thyroid diseases is achieved, and the method is suitable for application and popularization in grassroots with serious iodine deficiency and economically underdeveloped areas.

The invention provides a kit for quantitatively detecting urine iodine. The kit for quantitatively detecting urine iodine is characterized in that a detecting reagent in the kit is prepared from a urine iodine reagent R1, a urine iodine reagent R2 and a urine iodine calibration material, wherein the urine iodine reagent R1 is prepared from the following components: 0.1 to 1.50 mol / L of concentrated sulfuric acid, 0.5 to 2.0 mol / L of ammonium persulfate, 10 to 20 mmol / L of sodium chloride, 20 to 50 mmol / L of arsenic trioxide, 0.01 to 0.05 mol / L of catalyst I and 0.05 percent of preservative. The kit for quantitatively detecting urine iodine, provided by the invention, is suitable for detection and use of a full-automatic biochemical analyzer, a sample requires not to be subjected to digestive treatment in advance, the full-automatic biochemical analyzer can be directly used for determining, the determination time of the sample just requires 10 minutes, the detection time is greatly shortened, and the detection efficiency is improved.

The invention discloses a urine iodine detection method which comprises the following steps of: pretreating a urine sample to prepare a pretreated urine sample; adding a reducing agent, a phenanthroline solution and an oxidizing agent into the pretreated urine sample to prepare a mixed solution, wherein the reducing agent is an arsenious acid solution, and the oxidizing agent is an ammonium ceroussulfate solution or a cerous sulfate solution; taking a laser detector to emit laser with a preset wavelength to the mixed solution, collecting transmission light intensity in real time, and startingtiming; when the transmitted light intensity reaches a preset threshold value, stopping timing, and taking a time period from timing starting to timing stopping as reaction time; and calculating theiodine content in the urine sample according to the reaction time and a preset iodine content and time standard relation curve regression equation. The urine iodine detection method solves the problemof low detection result accuracy degree caused by naked eye judgment of a reaction endpoint in an existing arsenic-cerium catalytic timing determination method.

The invention discloses a blue light multi-thread concurrent detection device, a control system and an iodine element detector. The blue light multi-thread concurrent detection device comprises a light emitting diode assembly, an optical fiber group, a blue light signal transmitter group and a photoelectric signal receiver group; the optical fiber group comprises a plurality of light-passing optical fibers, the blue light signal transmitter group comprises a plurality of blue light signal transmitters, and the photoelectric signal receiver group comprises a plurality of photoelectric signal receivers; the two ends of each light-transmitting optical fiber are connected between the light-emitting diode assembly and the corresponding blue light signal transmitter. According to the invention, 1 to N samples can be simultaneously detected at the same time, the detection speed is greatly improved, the waiting period of a patient for a detection result is greatly shortened, the device has the characteristics of time saving, labor saving and labor saving, and urine iodine, water iodine, salt iodine, blood iodine and various iodine-containing substances can be detected.

The invention discloses an iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and an iodide ion detection method. In an acid medium, a tetravalent cerium solution or potassium permanganate solution is used for oxidizing an orange red Ferroin reagent solution into a blue solution in an acid medium, and a hydrazine saline solution is added to enable the blue solution to generate a reaction that blue is slowly faded to be turned into orange red; iodine has a sensitive oxidizing effect for the reaction, the higher the iodine concentration is, the higher thereaction speed is, a proportional relation is formed between the iodine concentration and the luminance value, and the iodine content of a sample can be calculated by an iodine standard curve. The detection result can be consistent to the result of the iodine tested by adopting a classical arsenic-cerium catalytic photometric method, and the use of a virulent hard-to-purchase arsenic trioxide reagent in the classical arsenic-cerium catalytic photometric method is avoided. The detection method has the advantages of being simple and convenient, rapid, specific, sensitive, accurate and the like,is expected to be widely applied to related fields needing to detect the iodine content of the sample, and especially is applied to urine iodine and water iodine detection in the fields of sanitary inspection and medical technology.

The invention discloses a rapid urine routine reagent box containing a urine iodine examination and detection equipment. In order to combine the urine iodine examination and a urine routine examination during a urine examination and improve the examination efficiency, according to the different structure of placing a simple inward of a urine iodine analyzer and a urine routine analyzer, an examination result of the urine iodine analyzer is inaccurate due to the fact that urine splashed out by the urine routine analyzer polluting the urine iodine analyzer is avoid. The urine iodine analyzer andthe urine routine analyzer are separately placed on an upper disk body and a lower disk body which are arranged up and down, the left sides and right sides of the upper disk body and the lower disk body form a parallelogram structure which places the upper disk body and the lower disk body always horizontally through a front swing arm and a rear swing arm, the different height requirements of different examinators can be adapted, and the contamination of the urine splashed by the urine routine analyzer to the urine iodine analyzer can be effectively avoided; and meanwhile, the situation thatthe examinators walk back and forth is avoided, the examination efficiency can effectively improved, and an efficient examination service is provided for patients who are anxious to wait for results.

The invention discloses a quantitative analysis system for urine iodine. The quantitative analysis system comprises a dropping bottle with urine filtering and purifying function, an extruding device for extruding urine in the dropping bottle to a test tube, a detection reagent for in-vitro detection of urine iodine content as well as a quantitative analyzer for in-vitro detection of urine iodine content in the detection reagent in the test tube. With adoption of the scheme, in-vitro detection has higher reproducibility and accuracy degree, the color developing gradient and color developing stability are quite good, the system is simple to use and operate, reaction detection consumes a little time, and too much processing of a urine sample is not needed; the system is simple, fast, high in accuracy and sensitivity, contains no heavy metal compounds or aldehyde condensation compounds, cannot cause environmental pollution and is safe and environment-friendly; detection results are used for evaluating iodine nutritional status of detected crowds and is suitable for being popularized and applied in primary health care institutions with severe iodine deficiency.

The invention discloses a high-precision urine iodine detection method which comprises the following steps: by taking N-bromosuccinimide as an oxidizing agent, oxidizing iodide ions in urine into iodate ions, introducing tetrabutylammonium iodide to react with the iodate ions, and forming an ion association compound by utilizing the electrostatic attraction effect between tetrabutylammonium cations and triiodide anions; and the ionic association compound is subjected to extraction and absorbance detection to establish a linear relationship between the iodine ion concentration and absorbance, thereby implementing high-precision detection on urine iodine. By means of the mode, the urine iodine can be safely and conveniently subjected to high-precision detection, the detection method is simple, convenient and easy to implement, high in detection speed and low in detection cost, the detection process has high sensitivity, precision and accuracy, high-precision detection of the urine iodinecan be achieved, the requirements of practical application can be met, and high application value is achieved.

The invention relates to a urine iodine determination kit, which includes a urine purification device, a diluent, a color developing solution, a composite oxidant and a standard color comparison plate; the urine purification device is a built-in device for specifically adsorbing interfering substances in urine The titration container of the selective specific adsorbent; the selective specific adsorbent is a baked activated adsorbent composed of purified activated carbon and iodine adsorption antagonist NaCl, MgCl2 or NaBr; the chromogenic solution is tetramethylbenzidine Aqueous solution and polyethylene glycol mixed reagent; composite oxidizing agent is a mixed oxidizing agent composed of peracetic acid, H2O2 and sodium anthracene sulfonate formaldehyde condensate; standard color guide plate is prepared by reacting urine with different iodine concentrations for 90 seconds The color is used as a standard color guide composed of color scales. It has the advantages of simple and fast removal of interfering substances in urine, accurate determination of iodine concentration in urine, and the like.

The invention discloses a urine iodine determination kit. The urine iodine determination kit comprises the following raw materials: a reagent R1 and a reagent R2. According to the invention, the urineiodine determination kit and the determination method thereof are strictly controlled; the proportion of each component of the urine iodine determination kit and preparation process parameters are strictly controlled; the urine is digested through ammonium persulfate; the urine does not need to be pretreated before detection; ferric ions react with iodide ions to generate ferrous ions and iodine,iodine reacts with sulfite ions and iodate ions to generate sulfate ions and iodide ions, the concentration of iodide ions in urine is determined by utilizing the indicator effect of phenanthroline on different iron ions, large-batch detection can be carried out, and a large amount of labor cost is reduced.

The invention discloses a high-precision urine iodine detection method which comprises the following steps: by taking N-bromosuccinimide as an oxidizing agent, oxidizing iodide ions in urine into iodate ions, introducing tetrabutylammonium iodide to react with the iodate ions, and forming an ion association compound by utilizing the electrostatic attraction effect between tetrabutylammonium cations and triiodide anions; and the ionic association compound is subjected to extraction and absorbance detection to establish a linear relationship between the iodine ion concentration and absorbance, thereby implementing high-precision detection on urine iodine. By means of the mode, the urine iodine can be safely and conveniently subjected to high-precision detection, the detection method is simple, convenient and easy to implement, high in detection speed and low in detection cost, the detection process has high sensitivity, precision and accuracy, high-precision detection of the urine iodinecan be achieved, the requirements of practical application can be met, and high application value is achieved.