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Iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and iodide ion detection method

A detection reagent and detection method technology, applied in the field of iodine ion detection, can solve the problems of failure to measure urinary iodine application, limited application range, low sensitivity, etc.

Active Publication Date: 2018-11-09
XIAMEN CENT FOR DISEASE CONTROL & PREVENTION
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  • Abstract
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Problems solved by technology

The instruments used in the ICP-MS method are expensive (one set is about 1.5 million yuan or more), and the cost of detection and operation is high, which is not conducive to popularization and application
[0006] Many other iodine non-arsenic and cerium reaction determination systems have problems of poor stability, low sensitivity, or obvious interference from the complex components of urine and the components of the solution to be tested after urine pretreatment, so that the scope of application is limited. , failed to be used in the determination of urinary iodine

Method used

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  • Iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and iodide ion detection method
  • Iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and iodide ion detection method
  • Iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and iodide ion detection method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Embodiment 1: Flow injection analysis detection of iodine content in urine

[0147] The iodide ion detection method and reagent of the present invention are used for determination.

[0148] (1) Reagent

[0149] (1.1) Digestion agent: ammonium persulfate solution {c[(NH 4 ) 2 S 2 o 8 ]=1.0mol / L};

[0150] (1.2) Neutralizer: sodium hydroxide solution, [c(NaOH)=0.50mol / L];

[0151] (1.3) Reagent R1: pure water, carrier solution for flow injection;

[0152] (1.4) Reagent R2: sodium acetate buffer solution (0.50mol / L sodium acetate-0.2mol / L hydrochloric acid);

[0153] (1.5) Reagent R3: hydrazine hydrochloride solution [ρ(N 2 h 4 2HCl)=20g / L];

[0154] (1.6) Reagent R4: Ferroin (ferrous spirit) solution, wherein the concentration of ferrous ammonium sulfate is 0.006mol / L, and the concentration of o-phenanthroline is 0.018mol / L;

[0155] (1.7) Reagent R5: ammonium cerium sulfate solution [c(Ce 4+ )=0.006mol / L];

[0156] (1.8) Iodine standard series solutions: Pot...

Embodiment 2

[0175] Embodiment 2: Flow injection analysis detection of iodine content in drinking water

[0176] The iodide ion detection method and reagent of the present invention are used for determination.

[0177] (1) Reagent

[0178] (1.1) Reagent R1: pure water, a carrier solution for flow injection.

[0179] (1.2) Reagent R2: hydrochloric acid solution [c(HCl)=1.0mol / L];

[0180] (1.3) Reagent R3: hydrazine hydrochloride solution [ρ(N 2 h 4 2HCl)=15g / L];

[0181] (1.4) Reagent R4: Ferroin (ferrous spirit) solution, wherein the concentration of ferrous ammonium sulfate is 0.005mol / L, and the concentration of o-phenanthroline is 0.015mol / L;

[0182] (1.5) Reagent R5: ammonium cerium sulfate solution [c(Ce 4+ )=0.005mol / L];

[0183] (1.6) Iodine standard series solution Ⅰ: Potassium iodate solution, the iodine content is 0, 2.5, 5.0, 10, 15, 20, 50, 100, 150, 200, 250 μg / L;

[0184] (1.7) Iodine standard series solution II: Potassium iodate solution, the iodine content is 0, 5...

Embodiment 3

[0204] Embodiment 3: biochemical analyzer detects iodine content in urine

[0205] The iodide ion detection method and reagent of the present invention are used for determination.

[0206] (1) Reagent

[0207] (1.1) Digestion agent: ammonium persulfate solution {c[(NH 4 ) 2 S 2 o 8 ]=1.0mol / L};

[0208] (1.2) Neutralizer: sodium hydroxide solution, [c(NaOH)=0.50mol / L];

[0209] (1.3) Reducing agent: hydrazine hydrochloride solution [ρ(N 2 h 4 2HCl)=25g / L].

[0210] (1.4) Reagent R1: Ferroin (ferrous spirit) solution, wherein the concentration of ferrous ammonium sulfate is 0.002mol / L, and the concentration of o-phenanthroline is 0.006mol / L;

[0211] (1.5) Reagent R2: ammonium cerium sulfate solution [c(Ce 4+ )=0.002mol / L];

[0212] (1.6) Iodine standard series solutions: Potassium iodate solution with iodine content of 0, 50, 100, 150, 200, 250, 300, 400 μg / L respectively.

[0213] (2) Sample pretreatment: Take 0.25 mL each of the iodine standard series solution an...

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Abstract

The invention discloses an iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and an iodide ion detection method. In an acid medium, a tetravalent cerium solution or potassium permanganate solution is used for oxidizing an orange red Ferroin reagent solution into a blue solution in an acid medium, and a hydrazine saline solution is added to enable the blue solution to generate a reaction that blue is slowly faded to be turned into orange red; iodine has a sensitive oxidizing effect for the reaction, the higher the iodine concentration is, the higher thereaction speed is, a proportional relation is formed between the iodine concentration and the luminance value, and the iodine content of a sample can be calculated by an iodine standard curve. The detection result can be consistent to the result of the iodine tested by adopting a classical arsenic-cerium catalytic photometric method, and the use of a virulent hard-to-purchase arsenic trioxide reagent in the classical arsenic-cerium catalytic photometric method is avoided. The detection method has the advantages of being simple and convenient, rapid, specific, sensitive, accurate and the like,is expected to be widely applied to related fields needing to detect the iodine content of the sample, and especially is applied to urine iodine and water iodine detection in the fields of sanitary inspection and medical technology.

Description

technical field [0001] The invention belongs to the technical field of iodine ion detection, relates to a reagent and a detection method for detecting urinary iodine and water iodine in the field of sanitary inspection and medical inspection, and in particular to an iodine ion detection reagent based on an iodine-catalyzed hydrazine-[oxidant-Ferroin reagent] system and methods. Background technique [0002] In the field of health and medicine, the detection of iodine ions is mainly the detection of urine iodine and water iodine. Urinary iodine is an important indicator for the monitoring of iodine deficiency disease prevention and control and the evaluation of iodine nutrition level in the population, which has been widely used at home and abroad. The urinary iodine level of the population can reflect whether the iodine intake of the population is iodine deficiency, iodine appropriate or iodine excess. The monitoring of the population's urinary iodine level is an important ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N21/31
CPCG01N21/31G01N21/78
Inventor 张亚平李呐黄淑英
Owner XIAMEN CENT FOR DISEASE CONTROL & PREVENTION
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