The invention discloses a preparation method of a compound traditional Chinese medicine nasal spray. The method involves with the following raw materials in parts by weight: 2-4 parts of honeysuckle stem, 1-2 parts of smilax glabra, 1-2 parts of Scutellaria baicalensis, 1-2 parts of sophora flavescens, 1-2 parts of mint, 1-2 parts of agastache rugosus, 1-2 parts of honeysuckle flower, 1-2 parts of chrysanthemum indicum, 1-2 parts of magnolia flower and 1-2 parts of herba houttuyniae. The preparation method comprises the following steps: mixing the raw materials and decocting with water, distilling and collecting volatile ingredients; stopping distilling, continuing decocting with water and concentrating, filtering and removing residues, refrigerating the liquid medicine and precipitating through night to obtain a clarified solution, and then mixing the clarified solution with the distillate, adding sodium benzoate, and finally adjusting the pH value, thereby obtaining the finished product. The compound traditional Chinese medicine nasal spray is capable of treating the diseases such as acute and chronic sinusitis and rhinitis, adenoidal hypertrophy of children and secretory otitis media, behaves well in the advantage of the traditional Chinese medicine of treating both symptoms and root causes, and is wide in application range and free from toxic and side effects; the compound traditional Chinese medicine nasal spray does not harm the previous physiological functions and structures of the turbinates, and further has the characteristics of simpleness and convenience in operation, relatively short course of treatment, satisfying effect, high cure rate and the like.