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Bulgaria inquinans polysaccharide, method for preparing the same and pharmaceutical composition using the compound as active component

The technology of gel gyroscope and polysaccharide is applied in the application field of extracts of active ingredients of traditional Chinese medicine, which can solve the problems of anti-tumor and increase leukocytes, and achieve the effects of less toxic and side effects, obvious curative effect, practical and convenient effects.

Inactive Publication Date: 2004-08-25
SHANGHAI HI TECH UNITED BIO TECHCAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using colloidal gyroscopes as raw materials, a large amount of colloidal gyroscope polysaccharides are prepared and made into medicines for medical clinical applications of anti-tumor, increasing white blood cells, anti-ulcer, anti-hepatitis, enhancing immunity, and lowering blood lipids.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103]Grind 1 kg of plastic gyro or mycelium, add 6 times of water to decoct for 3 hours, filter the filtrate, repeat 3 times, combine the filtrate, concentrate to 2000ml, place it, cool to room temperature, pass through the column with activated carbon twice, and collect the outflow solution, concentrated to 1000ml, added 5 times of ethanol to precipitate, stood for 24 hours, filtered, and added an appropriate amount of ethanol to elute, and the obtained precipitate was dried under reduced pressure (temperature 70°C, vacuum degree 0.090mPa) to obtain gelatinous gyro polysaccharide. Using phenol sulfuric acid method, at 490nm ultraviolet wavelength, with glucose as the reference substance, the purity of gum gyro polysaccharide is 45%.

Embodiment 2

[0105] Grind 1 kg of plastic gyro or mycelium, add 6 times of water to decoct for 3 hours, filter the filtrate, repeat 3 times, combine the filtrate, concentrate to 2000ml, place it, cool to room temperature, pass through the column with activated carbon twice, and collect the outflow solution, concentrated to 1000ml, added 5 times of ethanol to precipitate, stood for 24 hours, filtered, and added an appropriate amount of ethanol to elute, and the obtained precipitate was dried under reduced pressure (temperature 70°C, vacuum degree 0.090mPa) to obtain gelatinous gyro polysaccharide. Using phenol sulfuric acid method, at 490nm ultraviolet wavelength, with glucose as the reference substance, the purity of gum gyro polysaccharide is 45%. G after dosing 4 Filter through a funnel, and the filtrate is packaged and sterilized to make injections.

Embodiment 3

[0107] Glue gyro polysaccharide 1kg, medicinal starch 0.5kg, wet granulation with 80% ethanol concentration, granulate, dry, pack 1# capsules, each 0.2g. Other items should meet the requirements of capsules in the Pharmacopoeia of the People's Republic of China in 2000.

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PUM

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Abstract

The present invention provides a colloidal turbinate polysaccharide and its preparation method. Said method includes the following steps: pulverizing colloidal turbinate or its mycelium, decocting it by adding water, filtering to obtain filtrate, combining filtrates, concentrating, standing still, cooling to room temp., making the above-mentioned material pass through active carbon column twice, collecting effluent liquor, concentrating, adding ethyl alcohol to make precipitation, standing still, filtering, adding proper quantity of ethyl alcohol to make elution, reduced pressure drying the obtained precipitate so as to obtain the invented colloidal polysaccharide which can be used as main medicine or can be used for forming medicine prescription together with other medicines, and can be used for resisting tumor, increaisng white cell, resisting sore, resisting hepatitis, raising immunity and reducing blood fat.

Description

Technical field: [0001] The invention discloses a jelly top polysaccharide, and provides a preparation method thereof and a pharmaceutical composition using the compound as an active ingredient, and belongs to the technical field of application of active ingredient extracts of traditional Chinese medicines. Background technique: [0002] Bulgaria (Jiaotuoluo, Bulgaria) is the dry fruiting body of Bulgaria inquinans (Pers.) Fr., a fungus of the family Gyroidaceae, also known as "pig mouth mushroom" and "arch mouth mushroom". At present, due to the high medical value of gelatin top, ergosterol, galactitol and oxalic acid are isolated from it, and its medicinal value is being studied in depth. The pharmaceutical preparation (Tuoluo Yinxiao Capsule) made from the ethanol extract of Gum Gyro has the effect of treating psoriasis. However, using colloidal gyroscope as raw material, a large amount of colloidal gyroscope polysaccharides are prepared and made into medicines for medic...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/04A61P1/12A61P3/06A61P31/12A61P35/00A61P37/04C08B37/00
Inventor 徐凌于春波陈晓光
Owner SHANGHAI HI TECH UNITED BIO TECHCAL RES
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