Instrumented networks, machines and platforms having target subjects (devices, transactions, services, users, organizations) are disclosed. A security orchestration service generates runtime operational integrity profiles representing and identifying a level of threat or contextual trustworthiness, at near real time, of subjects (including mobile devices) and applications on the instrumented target platform. Methods and systems are disclosed for dynamic attestation of mobile device integrity based upon subject reputation scores. In an embodiment, a method scores trustworthiness of a mobile device based on reputation scores for users associated with the device and / or a device reputation score. The method generates runtime integrity alerts regarding execution anomalies for applications executing on the device, calculates risks based on a ruleset, and determines a calculus of risk for the device. The method sends endpoint events comprising data and content of the integrity warnings to a trust orchestrator, which generates an integrity profile based on the endpoint events.