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46 results about "Presynaptic neuron" patented technology

Presynaptic neuron. Type:Term. Definitions. 1. a neuron from the axon terminal of which an electrical impulse is transmitted across a synaptic cleft to the cell body or one or more dendrites of a postsynaptic neuron by the release of a chemical neurotransmitter.

Solving the distal reward problem through linkage of stdp and dopamine signaling

In Pavlovian and instrumental conditioning, rewards typically come seconds after reward-triggering actions, creating an explanatory conundrum known as the distal reward problem or the credit assignment problem. How does the brain know what firing patterns of what neurons are responsible for the reward if (1) the firing patterns are no longer there when the reward arrives and (2) most neurons and synapses are active during the waiting period to the reward? A model network and computer simulation of cortical spiking neurons with spike-timing-dependent plasticity (STDP) modulated by dopamine (DA) is disclosed to answer this question. STDP is triggered by nearly-coincident firing patterns of a presynaptic neuron and a postsynaptic neuron on a millisecond time scale, with slow kinetics of subsequent synaptic plasticity being sensitive to changes in the extracellular dopamine DA concentration during the critical period of a few seconds after the nearly-coincident firing patterns. Random neuronal firings during the waiting period leading to the reward do not affect STDP, and hence make the neural network insensitive to this ongoing random firing activity. The importance of precise firing patterns in brain dynamics and the use of a global diffusive reinforcement signal in the form of extracellular dopamine DA can selectively influence the right synapses at the right time.
Owner:NEUROSCI RES FOUND

Solving the distal reward problem through linkage of STDP and dopamine signaling

In Pavlovian and instrumental conditioning, rewards typically come seconds after reward-triggering actions, creating an explanatory conundrum known as the distal reward problem or the credit assignment problem. How does the brain know what firing patterns of what neurons are responsible for the reward if (1) the firing patterns are no longer there when the reward arrives and (2) most neurons and synapses are active during the waiting period to the reward? A model network and computer simulation of cortical spiking neurons with spike-timing-dependent plasticity (STDP) modulated by dopamine (DA) is disclosed to answer this question. STDP is triggered by nearly-coincident firing patterns of a presynaptic neuron and a postsynaptic neuron on a millisecond time scale, with slow kinetics of subsequent synaptic plasticity being sensitive to changes in the extracellular dopamine DA concentration during the critical period of a few seconds after the nearly-coincident firing patterns. Random neuronal firings during the waiting period leading to the reward do not affect STDP, and hence make the neural network insensitive to this ongoing random firing activity. The importance of precise firing patterns in brain dynamics and the use of a global diffusive reinforcement signal in the form of extracellular dopamine DA can selectively influence the right synapses at the right time.
Owner:NEUROSCI RES FOUND

Nerve cell synapse circuit and nerve cell circuit

The invention discloses a nerve cell synapse circuit and a nerve cell circuit, wherein the nerve cell synapse circuit comprises a charging circuit, a discharging circuit and an MOS (metal oxide semiconductor) capacitor, wherein the MOS capacitor is connected with the charging circuit and the discharging circuit; the charging circuit and the discharging circuit are both formed by a plurality of MOS devices, and are connected into a pulse sequence generated by nerve cells before the synapse and a pulse sequence generated by the nerve cells after the synapse; the charging circuit is constructed to charge the MOS capacitor when the pulse sequence generated by the nerve cells before the synapse is reached earlier than the pulse sequence generated by the nerve cells after the synapse so that the simulation voltage for increasing the synapse weight is output; the discharging circuit is constructed to discharge the MOS capacitor when the pulse sequence generated by the nerve cells before the synapse is reached later than the pulse sequence generated by the nerve cells after the synapse so that the simulation voltage for decreasing the synapse weight is output. The nerve cell synapse circuit and the nerve cell circuit provided by the invention have the advantages that the circuit power consumption can be reduced; the integration degree is improved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Memristive recurrent neural network circuit

The invention provides a memristive recurrent neural network circuit, which comprises a neuron module circuit, a reverse summation circuit and a memristive cross synaptic array circuit, wherein a pre-synaptic neuron in the memristive cross synaptic array circuit transmits a current signal to the input end of the neuron module circuit through a memristor; and the output end of the neuron module circuit transmits a current signal to the reverse summing module circuit, and the reverse summing circuit reversely propagates the current signal to the negative electrode of the memristor cross synapse array circuit. The memristive neural network is combined with associative memory, and a full connection layer of the artificial neural network is realized based on memristive, so that the network area and power consumption can be greatly reduced.
Owner:CHINA UNIV OF GEOSCIENCES (WUHAN)

Calculation method of neural synaptic plasticity based on calcium concentration

The invention relates to a calculation method of neural synaptic plasticity based on calcium concentration, which relates to the field of brain simulation, in particular to the calculation problem ofneural synaptic plasticity of impulse neural network in brain simulation. The first is the calculation of calcium ion concentration. According to the membrane potential values of presynaptic neurons and postsynaptic neurons at the initial time t0 and the initial connecting weight w0 of synapses, the calcium ion concentrations in dendrites and spines at the next time t1 are calculated respectivelyfor the synapses that need to be calculated. Secondly, according to the calcium ion concentration in dendritic spine, the direction of weight change was obtained by comparing with the calcium ion concentration threshold Ca0s and Ca1s. According to the synaptic state tag Tag and the plasticity related protein PRP concentration, the change of synaptic weight was calculated, and the new weight at time t1 was obtained. the above procedure is repeated to calculate the strength of synaptic connections within the simulation time. The method of the invention is applied to constructing a brain-like neural network, completing the simulation of the learning and memory process required by the brain-like intelligence, realizing the universal strong artificial intelligence, and is applied to intelligentmedia, medical treatment and the like.
Owner:COMMUNICATION UNIVERSITY OF CHINA

Linearly weight updatable CMOS synaptic array without cell location dependence

A neuromorphic circuit, chip, and method are provided. The neuromorphic circuit includes a crossbar synaptic array cell. The crossbar synaptic array cell includes a Complimentary Metal-Oxide-Semiconductor (CMOS) transistor having an on-resistance controlled by a gate voltage of the CMOS transistor to update a weight of the crossbar synaptic array cell. The neuromorphic circuit further includes a set of row-lines respectively connecting the synaptic array cell in series to a plurality of pre-synaptic neurons at first ends thereof. The neuromorphic circuit also includes a set of column-lines respectively connecting the synaptic array cell in series to a plurality of post-synaptic neurons at second ends thereof. The gate voltage of the CMOS transistor is controlled by performing a charge sharing technique that updates the weight of the crossbar synaptic array cell using non-overlapping pulses on control lines that are aligned with the set of row lines and the set of column lines.
Owner:IBM CORP

On-chip neural network-oriented synaptic implementation architecture

The invention belongs to the technical field of neural synapse implementation of brain-like computing chips, and relates to an on-chip neural network-oriented synapse implementation architecture based on three-level index and storage compression sharing. Synapses are connected with pre-synaptic neurons and post-synaptic neurons through a three-level index structure mode; connection information and weights in the three-level index structure mode can be stored in a synaptic storage device or distributed to pre-synaptic neurons and post-synaptic neurons, and the synaptic storage device adopts a weight sharing compression storage mode and a scene-based storage space sharing mechanism. Flexible configuration of the neural network topology structure can be supported, and the storage space of the neural network topology structure can be efficiently utilized.
Owner:ZHEJIANG LAB +1

Devices, apparatus and method for providing photostimulation and imaging of structures

According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and / or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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