The invention discloses a synthesis method of ponatinib. The method comprises the following steps: taking imidazo[1,2-b]pyridazine as a raw material, then subjecting the imidazo[1,2-b]pyridazine to react with N-halogenated succinimide so as to obtain 3-halogenated imidazo[1,2-b]pyridazine; making 3-iodo-4-R-benzoate carry out reactions to generate 4-R-3-trimethylsilylethynyl benzoate, then removing the trimethysilyl group so as to obtain 3-ethynyl-Rbenzonate, then carrying out reactions between 3-halogenated imidazo[1,2-b]pyridazine and 3-ethynyl-R-benzonate so as to obtain the reaction product 3-(imidazole[1,2-b]pyridazine-3-yl-ethynyl)-4-R-benzonate, then making the product react with 4-((4-methylpiperazine-1-yl) methylene)-3-trifluoromethyl phenylamine so as to obtain ponatinib, wherein the R represents one component selected from methyl, ethyl, propyl, isopropyl, n-butyl, and tertiary butyl. The synthesis process has the advantages of simple technology, mild reaction conditions, high product purity, high yield, low cost, and benefit for industrial production.