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Application of anidulafungin in preparation of antitumor drugs and antitumor drugs

An anti-tumor drug and drug technology, which is applied in the field of biomedicine, can solve the problems such as the anti-tumor effect of Anifungin, and achieve the effect of enhancing the anti-tumor effect and obvious effect

Active Publication Date: 2020-10-16
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]Currently, there is no report on the antitumor effect of anidulungin

Method used

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  • Application of anidulafungin in preparation of antitumor drugs and antitumor drugs
  • Application of anidulafungin in preparation of antitumor drugs and antitumor drugs
  • Application of anidulafungin in preparation of antitumor drugs and antitumor drugs

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Experimental program
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Embodiment Construction

[0029] The present invention will be described in detail below in conjunction with examples.

[0030] Cell experiments: Inhibitory effect of anidulungin on tumor cell growth.

[0031] Implemented drugs: Anidungin, cisplatin, ponatinib and pazopanib were purchased from a reagent company.

[0032] Tumor cell lines: human breast cancer cell MCF-7, human breast cancer cell MDA-MB-231, human liver cancer cell HepG2, human pancreatic cancer cell PANC1, and human glioblastoma cell T98G were purchased from the Advanced Research Center of Central South University. library.

[0033] Cell culture method: Carry out routinely, culture above-mentioned cells in DMEM medium (containing 10% fetal bovine serum, 100U / mL penicillin and streptomycin), when cell confluence grows to 90%, adopt trypsinization, wait for cell Shrunken and rounded, and the gap between cells is obvious, stop the digestion with medium immediately, break up the cells and blow them evenly into a single suspension state, s...

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Abstract

The invention relates to an application of anidulafungin in preparation of antitumor drugs and the antitumor drugs. The anidulafungin is used for preparing the antitumor drugs, especially drugs for resisting the breast cancer, the liver cancer, the pancreatic cancer, the brain tumor, the lung cancer, the kidney cancer, the melanoma, the chronic myeloid leukemia, the acute lymphoblastic leukemia and other tumors, and the effect is obvious. The anidulafungin is combined with other antitumor medicines, so that the antitumor effect of the antitumor drugs can be enhanced; and especially the anidulafungin is combined with cytotoxic antitumor medicines such as DNA structure and function affecting medicines such as cisplatin, transcription process interfering and RNA synthesis preventing medicinessuch as doxorubicin, and tyrosine kinase inhibitors such as ponatinib and pazopanib for application, so that the antitumor effect of the drugs can be enhanced.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of anifungin in the preparation of antitumor drugs and the antitumor drugs. Background technique [0002] Anifungin is a semi-synthetic echinocandin antifungal drug, which can inhibit the formation of fungal cell walls and has anti-Candida and Aspergillus activity. Listed in December 2006, it has a broader spectrum of antibacterial activity than similar drugs. Intravenous injection is used to treat patients with invasive candidiasis and candidemia, and it is also suitable for other types of candida infection (abdominal abscess, peritonitis) and esophageal candida. This drug has few adverse reactions. [0003] At present, there is no report on the antitumor effect of anidulungin. Contents of the invention [0004] During the drug screening process of isolated cells, the present inventor accidentally discovered that anidungin has the effect of inhibiting the growth of t...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P35/00A61P35/02
CPCA61K38/12A61P35/00A61P35/02
Inventor 罗秀菊彭军李悦琪贾苗苗张议月王倩琳黄钰琳彭靖杰刘斌
Owner CENT SOUTH UNIV
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