35 results about "Poly(glycerol-sebacate)" patented technology

A process is provided for preparing a polymeric material through a water-mediated polymerization process that includes combining an alcohol monomer and an aqueous solution in a vessel, adding an acid monomer to the vessel, removing water from the vessel and producing the polymeric material from the vessel, wherein the polymeric material comprises a polyester of the alcohol monomer and the acid monomer. The methods described herein are particularly suitable for polymerization of poly(glycerol sebacate).

The invention relates to a preparation method of a nanofiber scaffold for heart tissue engineering. The preparation method comprises the steps of preparing the nanofiber scaffold from poly(glyceroi sebacate) (PGS) / a gelatin nanofiber scaffold material with different components through electrostatic spinning, and crosslinking the nanofiber scaffold in a mixed solution of hydrochlorinated N,N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to obtain the nanofiber scaffold. The nanofiber scaffold related by the invention can be used for promoting the formation of sarcomere and has wide prospects on the aspect of being used as a material for cardiac muscle cell regeneration and repair.

The invention relates to glabridin micro-emulsion and a preparation method thereof. The glabridin micro-emulsion consists of the following components in percentage by weight: 10wt%-15wt% of glabridin, 10wt%-15wt% of stearic polyoxypropylene sulfite, 7wt%-11wt% of polydecyldiacid glyceride, 6wt%-9wt% of Twain 85, 12wt%-16wt% of propylene glycol and the balance of deionized water. The preparation method of the glabridin micro-emulsion comprises the steps of mixing and vortex oscillation, and the prepared glabridin micro-emulsion is high in encapsulation efficiency, good in stability and capable of being added into cosmetics as an ingredient for improving the stability of the glabridin.

The present invention relates to a biodegradable photocurable medical adhesive and preparation and application thereof, the adhesive is poly-glycerol-sebacate-grafted methyl acrylate (2-isocyano ethyl) ester (PGS-IM); the molecular structure is shown in the specification, poly glycerol sebacate (PGS) is added into a solvent, under nitrogen protection, then placed in an oil bath and stirred until the PGS is dissolved, then methyl acrylate (2-isocyano ethyl) ester is added for reaction for 15-120min, and the biodegradable photocurable medical adhesive can be obtained after purifying and drying. PGS-IM is viscous semi-solid at room temperature, is convenient to apply, and is Blu-ray or UV curable, free of damage to a tissue and rapid in curing, and after curing, adhesion properties are good.

The invention discloses an isocyanate crosslinked polyethylene glycol-polyglycerol sebacate bio-elastomer as well as a preparation method and an application thereof. The structure of the bio-elastomeris shown in formula I, wherein n is an integer of 10-80; m is an integer of 2-14. The bio-elastomer has the advantages that mechanical strength, hydrophilicity and hydrophobicity, degradation behavior, cell behavior and biocompatibility can be regulated and optimized through the content of isocyanate and polyethylene glycol, and is a soft tissue repair material with great clinical application prospect.

The invention discloses a mesoporous bioactive glass / poly-decyl diacid glyceride composite support as well as a preparation method and an application thereof. The composite support of the invention uses a mesoporous bioactive glass porous support as a matrix and compounds poly-decyl diacid glyceride on the mesoporous bioactive glass porous support. Mechanical strength, degradation rate, drug release rate, cell behavior and the like of the composite support of the invention can be adjusted by pore wall thickness of the mesoporous bioactive glass matrix and thickness of the poly-decyl diacid glyceride coating. A PGS coating is utilized to successfully solve the problem of brittleness of an MBG support, so that mechanical strength of the composite support is adjustable in a load bearing range of a trabecular bone. According to the invention, adjustment to degradation rate and release rate of proteins immobilized in MBG mesopore can be realized and activities of the immobilized proteins free of influence from a moderate coating operation can be realized; and cell experiments prove that the PGS coating is capable of promoting cell adhesion and proliferation on surface of the support without affecting osteogenic activity of the MBG.

The invention discloses a modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation and application thereof, wherein the modified polyethyleneglycol-poly (sebacic acid) (PEGS) injectable biological elastomer can be in-situ cured at body temperature. The biological elastomer is obtained by taking polyethylene glycol-poly glyceride sebacate (PEGS) as a matrix, and respectively performing sulfhydrylation and acrylation reaction on hydroxyl groups of the main chain or the side chain of the matrix, two modified PEGS can be mixed and then injected into a body and cured at the body temperature. The mechanical strength, hydrophilicity and hydrophobicity, degradation behavior, cell behavior and biocompatibility of the biological elastomer can be regulated and optimized through the content of polyethylene glycol and the proportion of carboxyl hydroxyl. The biological elastomer can be successfully prepared into injectable hydrogel materials for bone repair and tissue regeneration. The research results show that the modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer is a tissue repair material with a very wide clinical application prospect.

The invention relates to a poly(glycerolsebacate) 3D printing nano generator and a preparation method and application thereof. The poly(glycerolsebacate) 3D printing nano generator is obtained by carrying out mixing, 3D printing, thermo-crosslinking and pore-forming agent dissolution on poly(glycerolsebacate) PGS, carbon nanotubes CNTs and a pore-forming agent in sequence. The poly(glycerolsebacate) 3D printing nano generator has high elasticity and electrical conductivity; and through the use of a 3D printing technology, the preparation process of most of the current flexible integrated TENGsis simplified, and the TENGs can be processed into complex and variable three-dimensional structures, so that the shape design has diversity and flexibility, thereby promoting the further developmentof flexible integrated 3DP-TENGs on wearable electronic devices.

A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.

A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w / w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).

A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

Anesthetics covalently conjugated onto biodegradable and biocompatible hydrophilic polymers via hydrolysable linkages provide controlled release of local anesthetics in vivo in an effective amount for nerve blockade with reduced toxicity relative to the unconjugated anesthetic agent. The rate of anesthetic release can be tuned by changing the hydrophilicity of the polymer. Exemplary formulations of Poly (glycerol sebacate) (PGS), optionally including Poly ethylene glycol (PEG) polymers conjugated to Tetrodotoxin (TTX) (PGS-PEG-TTX and PGS-TTX), and methods of use thereof are provided Nerve blockade from PGS-PEG-TTX and PGS-TTX was associated with minimal systemic and local toxicity to the muscle and the peripheral nerves. TDP-TTX conjugates homogeneously dispersed into PEG200 are also described. PEG200 not only worked as a medium, but also worked as a chemical permeation enhancer (CPE) to enhance the effectiveness of TTX.

The invention provides a degradable shape memory polymer, its preparation method and application, and a 4D printed degradable inferior vena cava filter, belonging to the technical field of implantable medical devices. In the shape memory polymer provided by the present invention, the structural part of polyglycerol sebacate has an aliphatic long carbon chain structure, which can provide good biocompatibility, biodegradability and good cell binding performance; hydroxyethyl methacrylate The structural part provides the mechanical support required for the inferior vena cava filter; the acrylating group makes the composite material photocurable. The present invention uses the above-mentioned shape memory polymer and combines 3D printing technology to prepare a 4D printed degradable inferior vena cava filter, which is not only biodegradable, but also has good biocompatibility and ensures long-term patency of blood vessels; and has excellent mechanical properties and Deformability, can effectively intercept blood clots in a short period of time.

The present invention relates to a biodegradable photocurable medical adhesive and preparation and application thereof, the adhesive is poly-glycerol-sebacate-grafted methyl acrylate (2-isocyano ethyl) ester (PGS-IM); the molecular structure is shown in the specification, poly glycerol sebacate (PGS) is added into a solvent, under nitrogen protection, then placed in an oil bath and stirred until the PGS is dissolved, then methyl acrylate (2-isocyano ethyl) ester is added for reaction for 15-120min, and the biodegradable photocurable medical adhesive can be obtained after purifying and drying. PGS-IM is viscous semi-solid at room temperature, is convenient to apply, and is Blu-ray or UV curable, free of damage to a tissue and rapid in curing, and after curing, adhesion properties are good.

A method of producing a drug-loaded Poly (Glycerol Sebacate) (PGS) comprising providing PGS; dissolving at least one drug in a solvent; incubating the PGS in the solvent; and evaporating the solvent.

Anesthetics covalently conjugated onto biodegradable and biocompatible hydrophilic polymers via hydrolysable linkages provide controlled release of local anesthetics in vivo in an effective amount fornerve blockade with reduced toxicity relative to the unconjugated anesthetic agent. The rate of anesthetic release can be tuned by changing the hydrophilicity of the polymer. Exemplary formulations of Poly (glycerol sebacate) (PGS), optionally including Poly ethylene glycol (PEG) polymers conjugated to Tetrodotoxin (TTX) (PGS-PEG-TTX and PGS-TTX), and methods of use thereof are provided Nerve blockade from PGS-PEG-TTX and PGS-TTX was associated with minimal systemic and local toxicity to the muscle and the peripheral nerves. TDP-TTX conjugates homogeneously dispersed into PEG200 are also described. PEG200 not only worked as a medium, but also worked as a chemical permeation enhancer (CPE) to enhance the effectiveness of TTX.

A biocontainment vessel includes a vessel structure including a structural composition and an enhancement composition associated with the structural composition. The enhancement composition includes a co-polymer. The co-polymer is a poly(glycerol sebacate) or a poly(glycerol sebacate urethane). The enhancement composition may also include an augmentation agent associated with the co-polymer. The enhancement composition is located with respect to the structural composition such that the enhancement composition benefits biological cells contained in the biocontainment vessel. A composition includes a co-polymer and an augmentation agent contained by the co-polymer. A method of containing biological cells includes placing the biological cells in an augmented biocontainment vessel and storing them in the augmented biocontainment vessel under predetermined conditions. An augmented substrate includes a substrate and an enhancement composition coating a surface of the substrate.

A process of forming a coated textile includes culturing human cells on a fiber of a textile such that the human cells produce and deposit human extracellular matrix (hECM) on the textile. The process also includes removing the human cells from the hECM to provide the coated textile of the textile and a coating comprising a residual of the hECM produced and deposited by the human cells on the textile during the culturing. A coated textile includes a textile and a coating on the textile. The coating includes hECM in a cell-deposited state in the coating. A solid-state bioreactor composition includes a poly(glycerol sebacate) (PGS) adduct. The PGS adduct includes PGS and a promoting factor or a promoting factor precursor. Another method includes implanting a coated textile in a human. The coated textile is an autograft. The coating includes hECM deposited by human cells from the human.

The invention discloses a mesoporous bioactive glass / poly-decyl diacid glyceride composite support as well as a preparation method and an application thereof. The composite support of the invention uses a mesoporous bioactive glass porous support as a matrix and compounds poly-decyl diacid glyceride on the mesoporous bioactive glass porous support. Mechanical strength, degradation rate, drug release rate, cell behavior and the like of the composite support of the invention can be adjusted by pore wall thickness of the mesoporous bioactive glass matrix and thickness of the poly-decyl diacid glyceride coating. A PGS coating is utilized to successfully solve the problem of brittleness of an MBG support, so that mechanical strength of the composite support is adjustable in a load bearing range of a trabecular bone. According to the invention, adjustment to degradation rate and release rate of proteins immobilized in MBG mesopore can be realized and activities of the immobilized proteins free of influence from a moderate coating operation can be realized; and cell experiments prove that the PGS coating is capable of promoting cell adhesion and proliferation on surface of the support without affecting osteogenic activity of the MBG.

Provided is a degradable microparticle with a grain size in a range of 2 micrometers to 1400 micrometers, and the degradable microparticle comprises poly(glycerol sebacate), poly(glycerol maleate), poly(glycerol succinate-co-maleate), poly(glycerol succinate), poly(glycerol malonate), poly(glycerol glutarate), poly(glycerol adipate), poly(glycerol pimelate), poly(glycerol suberate), poly(glycerol azelate), or any combination thereof. A degradable product produced from the degradable microparticles can obtain the desired degradation effect and can be produced by chemical synthesis to reduce the production cost. With these advantages, the applicability of the degradable microparticles is improved.

The invention provides a degradable shape memory polymer, a preparation method and application thereof and a 4D printing degradable inferior vena cava filter, and belongs to the technical field of implantable medical instruments. In the shape memory polymer provided by the invention, a polysebacic acid glyceride structural part has an aliphatic long carbon chain structure, so that highd biocompatibility, biodegradability and high cell binding performance can be provided; a hydroxyethyl methylacrylate structure part provides mechanical support required by the inferior vena cava filter; and an acryloylated group enables the composite material to have photocuring performance. The shape memory polymer is used and combined with a 3D printing technology to prepare the 4D printing degradable inferior vena cava filter, and the 4D printing degradable inferior vena cava filter is biodegradable and has high biocompatibility, and the long-term patency rate of blood vessels is guaranteed; and the shape memory polymer has excellent mechanical properties and deformability, and can effectively intercept blood clots in a short period of time.

A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

The invention discloses a preparation method of shock-proof modified engineering plastic and application of the shock-proof modified engineering plastic. According to the method, poly(glycerol sebacate), triallyl cyanurate, an acrylonitrile-butadiene-styrol copolymer, magnesium oxide, manganese carbonate and an ethanol solution are mixed to obtain a primary mixture, then the primary mixture is putinto a dispersion solution of kynar and acrylic resin, after an antioxidant is added for standing treatment, sediments are collected, washed and dried to obtain a modified mixture, then after the modified mixture and maleic anhydride are mixed, heating and stirring are conducted for reaction to obtain an intermediate mixture, then secondary modification is conducted to obtain a secondary modifiedmixture, then the secondary modified mixture, sepiolite fibers and deionized water are reacted in a high-pressure reaction kettle in a helium environment to obtain a high-temperature reaction material, and finally, through melt extrusion, the finished product engineering plastic is obtained. The shock-proof effect of the prepared engineering plastic is good, and thus the engineering plastic has good application prospects in the fields of household appliances, electronic engineering, automobiles and communication.

The invention relates to glabridin micro-emulsion and a preparation method thereof. The glabridin micro-emulsion consists of the following components in percentage by weight: 10wt%-15wt% of glabridin, 10wt%-15wt% of stearic polyoxypropylene sulfite, 7wt%-11wt% of polydecyldiacid glyceride, 6wt%-9wt% of Twain 85, 12wt%-16wt% of propylene glycol and the balance of deionized water. The preparation method of the glabridin micro-emulsion comprises the steps of mixing and vortex oscillation, and the prepared glabridin micro-emulsion is high in encapsulation efficiency, good in stability and capable of being added into cosmetics as an ingredient for improving the stability of the glabridin.

A manufacturing process includes spinning at least one continuous poly(glycerol sebacate) (PGS) / alginate fiber from a polymeric solution comprising PGS and alginate in water, drafting the at least one continuous PGS / alginate fiber in at least one coagulation bath, and drawing the at least one continuous PGS / alginate fiber from the at least one coagulation bath. A yarn includes at least one continuous PGS fiber. A continuous poly(glycerol sebacate) (PGS) / alginate fiber forming system includes a feeding tank holding a polymeric solution of alginate and PGS, a pump, a spinneret, a first coagulation bath, a first winder, a second coagulation bath, a second winder, and a bobbin winder, the system forming at least one continuous PGS / alginate fiber from the polymeric solution of alginate and PGS.