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Glabridin micro-emulsion and preparation method thereof

A technology of glabridin and microemulsion, which is applied in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of low encapsulation rate, no significant, unstable state, etc., and achieve the effect of high content

Active Publication Date: 2014-08-13
WUJIANG YINGLIDA PLASTIC PACKAGING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The formulation of glabridin into microemulsion requires reasonable screening of emulsifiers and co-emulsifiers. Conventional emulsifiers have no significant effect in the microemulsion of glabridin, such as low encapsulation efficiency and state Unstable etc.

Method used

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  • Glabridin micro-emulsion and preparation method thereof
  • Glabridin micro-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] (1) Take glabridin powder 10g at room temperature, put the glabridin powder in a beaker, add polyoxypropylene stearate 15g, and stir evenly; (2) add polyglycerol sebacate in the beaker again for 11g and 6g of Tween 85, continue to stir evenly; (3) finally add 12g of propylene glycol and 46g of deionized water, stir evenly; (4) use a vortex oscillator to vortex the mixture in the beaker until the solution changes from cloudy Stop after reaching a clear state, and prepare a glabridin microemulsion.

Embodiment 2

[0014] (1) Take glabridin powder 13g at room temperature, put the glabridin powder in a beaker, add polyoxypropylene stearate 10g, stir well; (2) add polyglycerol sebacate in the beaker again for 7g and Tween 85 to 7g, continue to stir evenly; (3) finally add 16g of propylene glycol and 47g of deionized water, stir evenly; (4) use a vortex oscillator to vortex the mixture in the beaker until the solution is turbid Stop after reaching a clear state, and prepare a glabridin microemulsion.

Embodiment 3

[0016] (1) Take glabridin powder 15g at room temperature, put the glabridin powder in a beaker, add polyoxypropylene stearate 12g, stir well; (2) add polyglycerol sebacate in the beaker again for 9g and Tween 85 to 9g, continue to stir evenly; (3) finally add 14g of propylene glycol and 41g of deionized water, stir evenly; (4) use a vortex oscillator to vortex the mixture in the beaker until the solution changes from cloudy Stop after reaching a clear state, and prepare a glabridin microemulsion.

[0017] The particle size of the glabridin microemulsion prepared in Example 1, Example 2, and Example 3 was measured by a particle size analyzer, and the encapsulation efficiency and centrifugal stability were also measured.

[0018]

[0019]

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Abstract

The invention relates to glabridin micro-emulsion and a preparation method thereof. The glabridin micro-emulsion consists of the following components in percentage by weight: 10wt%-15wt% of glabridin, 10wt%-15wt% of stearic polyoxypropylene sulfite, 7wt%-11wt% of polydecyldiacid glyceride, 6wt%-9wt% of Twain 85, 12wt%-16wt% of propylene glycol and the balance of deionized water. The preparation method of the glabridin micro-emulsion comprises the steps of mixing and vortex oscillation, and the prepared glabridin micro-emulsion is high in encapsulation efficiency, good in stability and capable of being added into cosmetics as an ingredient for improving the stability of the glabridin.

Description

technical field [0001] The invention relates to a microemulsion and a preparation method thereof, in particular to a glabridin microemulsion and a preparation method thereof. Background technique [0002] Licorice contains a large amount of glabridin, which belongs to flavonoids and has a high content in licorice. Glabridin has good commercial value and has good uses in cosmetics, such as anti-oxidation, acne treatment, anti-inflammation, and melanin resistance. However, glabridin is not soluble in water, which limits the application of glabridin in cosmetics due to its insolubility in water. [0003] As a new mixed liquid, microemulsion has the advantages of small particle size and fast absorption. The formulation of glabridin into microemulsion requires reasonable screening of emulsifiers and co-emulsifiers. Conventional emulsifiers have no significant effect in the microemulsion of glabridin, such as low encapsulation efficiency and state Unstable etc. Contents of th...

Claims

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Application Information

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IPC IPC(8): A61K8/85A61K8/49A61K8/06A61Q19/00
Inventor 倪迪
Owner WUJIANG YINGLIDA PLASTIC PACKAGING
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