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Biodegradable photocurable medical adhesive and preparation and application thereof

An adhesive and light-curing technology, applied in the fields of application, surgical adhesives, medical science, etc., can solve the problems of rapid flushing, easy water swelling, cell damage, etc., and achieve convenient sizing and high bonding strength , good bonding performance

Active Publication Date: 2016-05-11
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these adhesives are hydrophilic, and are easy to absorb water and swell in the body or be washed away quickly by flushing
In addition, the current research on photocuring medical adhesives is mostly focused on UV curing. Because ultraviolet light can damage tissues and cells, its application is limited.

Method used

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  • Biodegradable photocurable medical adhesive and preparation and application thereof
  • Biodegradable photocurable medical adhesive and preparation and application thereof
  • Biodegradable photocurable medical adhesive and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Preparation of PGS: Add 20.2574g (0.1mol) of sebacic acid (0.1mol) and 9.2037g (0.1mol) of glycerol after recrystallization and purification into a three-necked flask, melt at 135°C, and pass through N 2 Stir for 24h, then evacuate (4mbar) at 135°C for 48h, cool down to room temperature to give a pale yellow waxy solid.

[0043] 1 HNMR (400MHz, Chloroform-d) δ 3.45-5.29 (m, 5H), 2.35 (m, 4H), 1.62 (m, 4H), 1.35 (m, 4H).

[0044] Synthesis of PGS-IM: The feeding of the reaction is carried out in a glove box (water content ≤ 0.1ppm, oxygen content ≤ 0.1ppm), weighing 1210.0mg (4.69mmol) PGS into a 25ml eggplant-shaped reaction bottle, and then adding 1.6ml without DMF in water, under nitrogen protection, placed in an 80°C oil bath and stirred until PGS was completely dissolved. 359.5 mg (2.35 mmol) of (2-isocyanoethyl)methacrylate were added and the reaction was complete after 20 minutes. Precipitate with deionized water to remove DMF, then dissolve with tetrahydrofuran...

Embodiment 2

[0053] Preparation of PGS: Add 20.2574g (0.1mol) of sebacic acid (0.1mol) and 9.2037g (0.1mol) of glycerol after recrystallization and purification into a three-necked flask, melt at 135°C, and pass through N 2 Stir for 24h, then evacuate (4mbar) at 135°C for 48h, cool down to room temperature to give a pale yellow waxy solid.

[0054] Synthesis of PGS-IM: The feeding of the reaction is carried out in a glove box (water content ≤ 0.1ppm, oxygen content ≤ 0.1ppm), weighing 4.69mmol) PGS is added to a 25ml eggplant type reaction bottle, and then 1.6ml anhydrous DMF is added, Under nitrogen protection, place in an 80°C oil bath and stir until the PGS is completely dissolved. Add 4 mmol (2-isocyanoethyl) methacrylate, and the reaction ends after 20 minutes. Precipitate with deionized water to remove DMF, then dissolve with tetrahydrofuran, and precipitate with deionized water three times to remove unreacted (2-isocyanoethyl) methacrylate monomer to obtain a white viscous semi-sol...

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Abstract

The present invention relates to a biodegradable photocurable medical adhesive and preparation and application thereof, the adhesive is poly-glycerol-sebacate-grafted methyl acrylate (2-isocyano ethyl) ester (PGS-IM); the molecular structure is shown in the specification, poly glycerol sebacate (PGS) is added into a solvent, under nitrogen protection, then placed in an oil bath and stirred until the PGS is dissolved, then methyl acrylate (2-isocyano ethyl) ester is added for reaction for 15-120min, and the biodegradable photocurable medical adhesive can be obtained after purifying and drying. PGS-IM is viscous semi-solid at room temperature, is convenient to apply, and is Blu-ray or UV curable, free of damage to a tissue and rapid in curing, and after curing, adhesion properties are good.

Description

technical field [0001] The invention belongs to the field of adhesives and their preparation, in particular to a degradable photocurable medical adhesive and its application. Background technique [0002] Suture technique is the key to the success of surgery, which is quite technically difficult, time-consuming and poorly uniform. For surgical suturing, if the suturing is not tight, it may cause local tissue bleeding, infection or even non-healing. As a new closure technology, medical adhesive is easy to use, quick to operate, and has the advantages of hemostatic function, so it has attracted more and more attention. Currently clinically available adhesives mainly include medical-grade cyanoacrylate (CA) and fibrin sealant. The former has certain toxicity when used in vivo, while the latter has weak cohesiveness and is easily washed off, so their application is restricted. limit. In recent years, more and more researches on new medical adhesives have been developed, such ...

Claims

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Application Information

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IPC IPC(8): A61L24/06C08G63/91C08G63/12
CPCA61L24/06C08G63/12C08G63/914C08L51/08
Inventor 游正伟黄鹏赵强叶晓峰王敏龚文辉
Owner DONGHUA UNIV
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