31 results about "Pituitary tumours" patented technology

The embodiments of the application discloses a pituitary tumor image classification method, a pituitary tumor image classification system and electronic equipment. The method comprises the following steps: acquiring a magnetic resonance image of a brain to be classified; inputting the magnetic resonance image of the brain to be classified into a classification model, wherein the classification model is an artificial neural network comprising an attention module, and the classification model is obtained after training by taking the extracted magnetic resonance images form the area where the pituitary tumor is located as a first training sample; extracting image features in the magnetic resonance image of the brain through the classification model, determining the importance degree of each image feature in the the magnetic resonance image of the brain through the attention module, and obtaining a classification result corresponding to the magnetic resonance image of the brain based on the importance degree of each image feature. By implementing the embodiment of the invention, the importance degree of the image feature can be determined through the attention module according to the contribution of each image feature to the classification task, so that the classification accuracy is improved.

The invention discloses an application of miRNA-424 as a diagnostic marker of pituitary adenoma and preparation or screening of drugs for treating pituitary adenoma. The invention discovers for the first time that the expression level of miRNA-424 is related to the occurrence of pituitary adenoma. By detecting the expression level of miRNA-424 in a patient, whether the subject has the risk of pituitary adenoma can be judged, thereby guiding the clinician to provide a prevention scheme or a treatment scheme for the subject.

The invention discloses a medicament for treating hypophysis cancer, which is prepared from fleece-flower root, sophora bud, Dendrobium nobile, polyporus umbellatus, dodder seed, Chinese honeylocust abnormal fruit, apiary and pangolin by a predetermined weight proportions. The medicament can be prepared into any of the conventional oral administration dosage forms.

The invention discloses a conchoscope for a transsphenoidal pituitectomy, which comprises a conchoscope body and an eye lens, wherein the conchoscope body comprises a protection tube, an image transmission system and an image adjusting knob; the image transmission system is arranged in the protection tube; the eye lens is arranged at the front end of the protection tube and connected with the image transmission system; the image adjusting knob is arranged at the rear part of the conchoscope body; a suction hole and a connecting port are formed in the protection tube; the suction hole is located above the eye lens; the connecting port is located near the image adjusting knob; a slim tube is arranged in the protection tube and near a tube wall; the slim tube is communicated with the suction hole and the connecting port; the connecting port is connected with an electric negative pressure suction device; and a suction control button is further arranged at the connecting port.Compared with the prior art, the conchoscope can timely clear away smoke and blood caused intraoperatively, ensures a good operation environment, allows an operator to be proficient operationally, ensures effective conduction of an operation, is reasonable in structural design, and safe and reliable in performance, and facilitates improving an operation effect.

The invention discloses the use of hordenine in the preparation of drugs for treating pituitary tumors, and relates to the technical field of biopharmaceuticals. Specifically, in this application, the inventors have discovered that hordenine can inhibit TLR4 / NF-κB / The MAPK signaling pathway helps to treat prolactinoma and adrenocorticotropic adenoma to play a drug effect, and solves the plight of drug shortage for patients with prolactinoma and adrenocorticotropic adenoma.

The invention discloses a method for grading pituitary tumor texture images based on fine-grained medical image segmentation and true value discovery data amplification, comprising the following steps: Step 1: medical image segmentation based on fine-grained optimization of Drosophila-density peak clustering; Step 2: Amplification of pituitary tumor data based on true value discovery; Step 3: Grading of pituitary tumor texture images based on Step 1 and Step 2. The present invention accurately segments medical images through the fusion of fine-grained partitioning algorithm and FOA-DPC algorithm; the present invention also realizes medical image data amplification based on truth discovery theory, and solves the problem of too few available medical image data sets. The invention combines the KFOA‑DPC segmentation algorithm with deep learning to solve the problem of dicom format images with complex gray levels and difficult feature extraction, realize the soft and tough classification of pituitary tumors, and assist clinical diagnosis.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The invention discloses a pituitary tumour cutting and clearing-away device. The pituitary tumour cutting and clearing-away device comprises an external clearing-way machine, a drainage tube and a sucking mechanism, wherein the external clearing-away machine is connected to the drainage tube; a negative-pressure suction machine is started; the drainage tube is used for guiding and draining pituitary tumours into a tumour substance collecting box; a sucking head sucks pituitary tumours; after last-time sucking is finished, the sucking tube is pulled upwards, so that extrusion force, on elastictelescopic plates at two sides, of the sucking tube disappears, the elastic telescopic plates at the two sides are shrunk to be closed in a contact mode, and therefore, the drainage tube is preventedfrom generating reflow to make sucked pituitary tumours flow back, the sucking head is prevented from being exposed in air for a long term to be infected with bacteria, and possibility of bacterial infection in operation is reduced; when the sucking mechanism is used again, the sucking tube is downwards extruded, so that two side walls of the sucking tube cling to the elastic telescopic plates, and the sucking head passes through a tube orifice to suck the pituitary tumours; the sucking head adopts a flat tube body, and the inner cavity of the sucking head is gradually reduced from back to front, and a formed liquid knife is more sharp, so that practicability of the device is improved.

The invention provides a non-functional pituitary adenoma detection device and its application. The device of the present invention performs Massarray SNP typing detection on the single nucleotide polymorphism site rs2981582 of the sample to be tested. This site has a significant correlation with the pathogenesis of non-functioning pituitary tumors. The different genetic models of this locus can provide a certain basis for the diagnosis of non-functioning pituitary tumors and have high clinical value. The invention can provide a simple and reliable diagnostic method for the early diagnosis of patients with non-functional pituitary tumors.

The present invention discloses a pituitary tumor sampling device convenient for separating pituitary tumor. The device comprises a bottom plate, supporting legs, universal wheels, a first supporting rod, a first telescopic rod, a first fixing plate, a bracket, a second supporting rod, a wire winding rod, a chassis, a fixing base, a second telescopic rod, a limiting rod, a third telescopic rod, an instrument tray, a transverse rod, a stabilizing device and the like. The device is reasonable and simple in structure, low in production cost and convenient to mount, the whole device is more convenient to move through the arranged universal wheels, doctors and patients do not need to walk back and forth to take medical instruments through the arranged instrument tray, and the working intensity is reduced; through the arrangement of the first supporting rod, the first telescopic rod, the first fixing plate, the bracket, the second supporting rod and the wire winding rod, a drainage tube needing to be used when the device is used can be wound and placed; and according to the invention, pituitary tumors can be better fixed through the arranged stabilizing device, so that subsequent sampling, cutting and the like are facilitated.

The invention relates to a Chinese medicine composition for treating pituitary tumor, which is prepared from the following bulk pharmaceutical chemicals in parts by weight: 15-25 parts of arisacma consanguineum, 10-20 parts of seaweed, 25-35 parts of raw oyster, 4-14 parts of ginger processed pinellia, 7-17 parts of rhizoma sparganii, 10-20 parts of salvia chinensis, 7-17 parts of poria cocos and 25-35 parts of raw astragalus mongholicus. The invention also provides an application of the Chinese medicine composition. The Chinese medicine composition has the advantages that the compatibility of the Chinese medicine composition conforms to the assistant and guide principle of the traditional Chinese medicine. The clinical test proves that the Chinese medicine composition disclosed by the invention has obvious curative effect advantages, and has good curative effect on eliminating pituitary tumor, lowering the postoperative recurrence rate and reducing side effect after the western medicine is taken. The Chinese medicine composition also has good curative effect, no obvious toxic or side effect, no adverse reaction and wide clinic application prospect.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention relates to a transsphenoidal pituitary tumor locating device based on ultrasonic blood flow detection guidance. The device consists of a phased array ultrasonic Doppler transducer and anultrasonic main machine, wherein the ultrasonic main machine comprises a central control processing unit, a transmitting / receiving circuit module and a graphic display module, and the ultrasonic Doppler transducer comprises a piezoelectric unit, a transmitting amplifier and a receiving amplifier. The device adopts a phased array technology for carrying out different time delay processing on signals input and output by an array in the transducer. By calculating and obtaining information such as the tissue distance, the blood vessel depth and the Doppler frequency shift amount at the detectionposition and displaying the information in the form of images, the transducer does not need to be rotated mechanically, the blood vessel detection efficiency is improved, and accidental injuries possibly caused in an operation process are avoided.

The invention discloses a fibrinogen compound and an application thereof. The fibrinogen compound comprises fibrinogen, prothrombin and eleven neurotrophic factors. The fibrinogen compound can be used for preparing drugs for treating glaucoma, hypophysoma, traumatic optic nerve injury, operation caused optic nerve injury and the like; and when the compound is combined with transplanted cells, the transplanting repair effect can be enhanced.

The invention provides a non-functional pituitary adenoma detection device and its application. The device of the present invention performs Massarray SNP typing detection on the single nucleotide polymorphism site rs2910200 of the sample to be tested. This site has a significant correlation with the pathogenesis of non-functioning pituitary tumors. The different genetic models of this locus can provide a certain basis for the diagnosis of non-functioning pituitary tumors and have high clinical value. The invention can provide a simple and reliable diagnostic method for the early diagnosis of patients with non-functional pituitary tumors.