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Non-functional pituitary adenoma detection device and application

A pituitary adenoma, functional technology, applied in the field of molecular biology, can solve the problems of unclear pathogenesis of pituitary adenoma, difficulty in early diagnosis, etc., and achieve the effect of simple and reliable diagnosis method and high clinical value

Active Publication Date: 2022-05-03
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

However, the pathogenesis of pituitary tumors is still unclear, and early diagnosis is still relatively difficult. If a clear diagnosis can be made at the early stage of tumor occurrence, it will help prevent irreversible neurological damage caused by the continuous hidden growth of the tumor and reduce the risk of treatment. very important

Method used

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  • Non-functional pituitary adenoma detection device and application
  • Non-functional pituitary adenoma detection device and application
  • Non-functional pituitary adenoma detection device and application

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Embodiment 1

[0078] The case group consisted of 79 patients with pituitary adenoma who were treated and operated on at Beijing Tiantan Hospital Affiliated to Capital Medical University. All patients with pituitary adenoma were diagnosed as non-functioning pituitary adenoma by clinical manifestations, endocrine laboratory examination, and imaging examination. All patients were excluded from other malignant diseases (such as meningioma, glioma, lymphoma, etc.); 144 cases of healthy controls were from the same period of healthy physical examination personnel in our hospital. All the subjects included in the study were normal healthy people without pituitary adenoma and no family history of pituitary adenoma. The general information of the research subjects is shown in Table 1.

[0079] Table 1 General information of research objects

[0080] control patient Gender: Male Female) 142(69 / 73) 79(41 / 38) age 42.12±11.63 41.37±11.63 weight 69.04±14.35 72.26±13 ...

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Abstract

The invention provides a non-functional pituitary adenoma detection device and its application. The device of the present invention performs Massarray SNP typing detection on the single nucleotide polymorphism site rs2981582 of the sample to be tested. This site has a significant correlation with the pathogenesis of non-functioning pituitary tumors. The different genetic models of this locus can provide a certain basis for the diagnosis of non-functioning pituitary tumors and have high clinical value. The invention can provide a simple and reliable diagnostic method for the early diagnosis of patients with non-functional pituitary tumors.

Description

technical field [0001] The invention belongs to the field of molecular biology, and in particular relates to a non-functional pituitary adenoma detection device and its application. Background technique [0002] Pituitary tumor is one of the common neuroendocrine tumors that can lead to the imbalance of pituitary hormone secretion. Its incidence ranks third in the incidence of intracranial tumors after glioma and meningioma. Epidemiological studies have shown that the incidence rate of pituitary tumors in the general population is as high as 16.7%, and they can occur at any age, most of whom are 30-50 years old. Nonfunctioning adenomas account for about 15%-54% of pituitary tumors. Because non-functioning pituitary adenomas cannot show hormone-related syndromes and lack obvious relevant clinical symptoms, early diagnosis in clinical practice is quite difficult. [0003] Patients with pituitary tumors may have clinical manifestations ranging in severity at different periods...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/156
Inventor 朱斌赵志刚康熙雄高明
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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