32 results about "P-chlorobenzotrifluoride" patented technology

The invention discloses a continuous synthetic method and synthetic equipment for 3,4-dichlorotrifluoromethyl benzene. The continuous synthetic method comprises the following steps: using chlorine and p-chlorobenzotrifluoride as raw materials; sufficiently mixing the chlorine and the p-chlorobenzotrifluoride as the raw materials with a circulating material by a raw material mixer; then enabling a mixture to enter a chlorination tower filled with iron filler from the bottom, and carrying out continuous chlorination reaction; using one part of a reactant obtained from the top of the chlorination tower as the circulating material, and enabling the circulating material to return to the raw material mixer for carrying out continuous mixed reaction; refining residual materials to obtain a product 3,4-dichlorotrifluoromethyl benzene. The synthetic equipment comprises a feeding mixer, wherein an outlet of the feeding mixer is communicated with a lower inlet of the chlorination tower; a gas-liquid separator is communicated with a top outlet of the chlorination tower; a liquid phase outlet of the gas-liquid separator is respectively communicated with a product refining device and a liquid phase raw material inlet of the feeding mixer; the iron filler fills the chlorination tower. The continuous synthetic method and the synthetic equipment disclosed by the invention disclosed by the invention can realize continuous production and have the advantages of high capacity, low energy consumption, simplicity and convenience in operation and environment friendliness.

This invention is involved with a preparation method of 2,6-dichloro-4-trifluoromethyl-aniline. With this process, p-Chlorobenzotrifluoride is used as the starting material and subjected to halogenation reaction and ammoniation reaction and through separation of reaction products the desired 2,6-dichloro-4-trifluoromethyl-aniline is obtained. In addition, ammonia is recovered from the surplus ammonia water in ammoniation reaction. This applied invention in characterized by simple process, cheap and easy-available raw materials, high reaction yield and friendly environment.

The invention relates to a method for preparing antidepressant fluoxetine, and belongs to the method for preparing a medicinal compound. The technical scheme in the invention comprises the following three steps of aminolysis, catalytic hydrogenation and aromatic etherification reaction, wherein the three steps are performed in one pot without separation. In the method, the conventional chemical reduction method is replaced by the catalytic dehydration process, and the used reducing agent is hydrogen gas, so that the environmental pollution is reduced; the methylamine is gaseous methylamine, so that the reaction conversion rate is improved, and other substances, such as water and the like, are prevented from being introduced into a reaction system; and p-chlorobenzotrifluoride is added dropwise in the etherification reaction, so that the reaction speed can be conveniently controlled, the yield of a target product is improved, and the possibility of catalyst poisoning is reduced.

The invention relates to a synthetic method of p-trifluoromethylaniline; p-chlorobenzotrifluoride and liquid ammonia generate an ammonolysis reaction to generate the p-trifluoromethylaniline under the action of a catalyst and an acid-binding agent; according to portion by weight, the components of the catalyst is: cuprous chloride of 1 to 10 portions, potassium fluoride of 2 to 30 portions and phase transfer catalyst of 5 to 30 portions; the adding amount of the catalyst is 8 to 70 percent of the p-chlorobenzotrifluoride (mass); the synthetic method of the invention adopts an effective compound catalyst to provide a synthetic scheme which has higher one way conversion rate and is economically practical in industry for the synthesis of the p-trifluoromethylaniline; the price of the catalyst used in the synthetic process is lower; furthermore, an organic solvent and the phase transfer catalyst can be recycled and reused; the manufacture cost is low; no waste water is discharged during the whole technique process; and the synthetic method of the invention is friendly to the environment.

The invention belongs to the technical field of medicine, and in particular relates to a synthetic method of 4-chloro-3-(trifluoromethyl)phenylisocyanate. The reaction of o-chlorobenzotrifluoride, acetic anhydride and concentrated nitric acid gives 4-nitro-2-trifluoromethyl chlorobenzene, 4-nitro-2-trifluoromethyl chlorobenzene, activated carbon, FeCl 3 ·6H 2 O reacts with hydrazine hydrate to obtain 4-chloro-3-trifluoromethylaniline, and 4-chloro-3-trifluoromethylaniline, triphosgene and catalyst react to obtain 4-chloro-3-(trifluoromethyl) benzene isocyanate . The nitration process of the present invention uses the acetic anhydride / concentrated nitric acid system to replace the traditional nitric acid / sulfuric acid mixed acid system, and the strong nitration effect of acetyl nitrate can complete the reaction at a lower temperature, with low risk and less nitration impurities; the reduction process uses FeCl 3 ·6H 2 The O / activated carbon / hydrazine hydrate system replaces the traditional iron powder reduction process, which avoids the generation of a large amount of iron sludge and waste, and reduces the pressure on environmental protection.

The invention discloses a new method of clean nitration reaction of p-chlorobenzotrifluoride under catalysis of degradable functional ionic liquid. Biodegradable ionic liquid of quaternary ammonium cation structure is used as a catalyst, p-chlorobenzotrifluoride and nitric acid are used as raw materials, and 4-chloro-3-nitrobenzotrifluoride is obtained by nitration reaction under the action of the catalyst. Compared with the prior art, the method has the advantages that: (1) because the degradable ionic liquid of quaternary ammonium cation structure is adopted, the raw material source is extensive, and the preparation is convenient; the catalyst has high activity, low consumption and water stability, is not inactivated and can be recycled; (2) the ionic liquid is biodegradable and environment-friendly; and (3) because the ionic liquid is used for substituting concentrated sulfuric acid, the method is an environment-friendly chemical process, and has good industrialized application prospect.

The invention discloses an injection needle coating material and application thereof in surface treatment of a peripheral blood taking needle head, and relates to the technical field of biomedical materials. According to the injection needle coating material, an injection needle head is soaked in a coating solution to form a coating on the surface of the needle head, and the coating solution is prepared from the following raw materials in parts by weight: 1 to 4 parts of modified silicone oil, 20 to 30 parts of 4-chlorobenzotrifluoride, 15 to 30 parts of ethyl acetate, 2 to 4 parts of hydroxypropyl methyl cellulose, 3 to 8 parts of dimethylformamide, 0.5 to 2 parts of fucosan sulfate and 0.1 to 1 part of luteolin-5-O-glucoside. The coating material prepared by the invention has good cohesiveness, is not easy to fall off when being coated on the surface of the needle head, and can greatly reduce the pain of a sick body during puncture; and the coating material has an excellent anticoagulant effect, and can relieve the problem that the blood coagulation of a patient is fast and is not beneficial to follow-up test.

The invention provides a method for synthesizing 2, 5-dichlorobenzotrifluoride through continuous flow catalytic chlorination, and belongs to the field of synthesis processes. According to the method, o-chlorobenzotrifluoride and chlorine are taken as raw materials, and the 2, 5-dichlorobenzotrifluoride is synthesized in a continuous flow reactor with high selectivity in the presence of a catalyst. Compared with the traditional method, the synthesis method disclosed by the invention has the advantages that the selectivity is higher, the generation of byproducts is greatly reduced, the reaction time is shortened, the production efficiency is improved, the 2, 5-dichlorobenzotrifluoride with high yield and high purity is obtained, and the industrial application prospect is very good.