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34 results about "Membrane staining" patented technology
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Sometimes the staining appears as a clear rim around the cell and sometimes membrane protrusions extending from the plasma membrane are clearly visible. In other cases the staining can be uniform and flat across the entire cell (since the plasma membrane beneath the cell is stained).
Immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment
The invention relates to an immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment. The image processing method comprises the following steps: acquiring a digital section full-field image of a to-be-diagnosed immunohistochemical PD-L1 (SP263) membrane staining pathological section; adopting a region segmentation network to identify and segment a tumor cell region in the digital slice full-field image under the first visual field multiplying power to obtain a tumor cell region probability graph of the whole digital slice full-field image;identifying and segmenting cells in each digital slice full-field graph, taking the tumor cell region probability graph as a weight matrix to carry out region constraint on the cell positioning network, identifying cell characteristics on the digital slice full-field graph, and positioning and classifying various cells on the digital slice full-field graph; and marking the cell position, the celltype and the immunohistochemical PD-L1 (SP263) index on the full-field diagram of the digital slice. By designing a multi-level feature collaborative diagnosis strategy, the tumor proportion score isaccurately evaluated in a mode of constraining cell features by using regional features.
Owner:杭州迪英加科技有限公司 +1
Immunohistochemical membrane staining section diagnosis method and device
PendingCN110853005AGuaranteed accuracyImprove robustnessImage enhancementImage analysisFull fieldImage restoration
The invention relates to an immunohistochemical membrane staining section diagnosis method. The method comprises the following steps: S10, receiving a digital section full-field graph of a to-be-diagnosed immunohistochemical membrane staining pathological section; S20, performing quality evaluation on the region of interest on the digital slice full-field image, and performing image restoration onthe region with unqualified quality evaluation to obtain a region of interest with qualified quality evaluation; S30, carrying out cell positioning, classification and segmentation on the regions ofinterest with qualified quality evaluation, marking cell positions and cell types on the regions of interest, and calculating and marking immunohistochemical indexes; and S40, displaying the marked region of interest. The invention further relates to an immunohistochemical membrane staining section diagnosis device and a computer readable medium. Since the context information of the lesion area isof great significance to interpretation of the immunohistochemical membrane staining section, the accuracy of interpretation is ensured by collecting the eight-connected patch image of the immunohistochemical membrane staining pathological section with time sequence for training and testing.
Owner:杭州迪英加科技有限公司
Image enhancement to enable improved nuclei detection and segmentation
PendingUS20210295507A1Easy to detectSimple structureImage enhancementImage analysisCytoplasmic stainingCytoplasm
Aspects of the present disclosure pertain to systems and methods for enhancing brightfield or darkfield images to better enable nucleus detection. In some embodiments, the systems and methods described herein are useful for identifying membrane stain biomarkers as well as nuclear / cytoplasm stain biomarkers in stained images of biological samples. In some embodiments, the presently disclosed systems and methods enable quick and accurate nucleus detection in stained images of biological samples, especially for original stained images of biological samples where the nuclei appear faint.
Owner:VENTANA MEDICAL SYST INC
Method for observing dynamic distribution of tumor cell exosome and exosome internal miRNA in recipient cells
InactiveCN108192951AAchieving super-resolution optical imagingCareful observationMicrobiological testing/measurementFluorescence/phosphorescenceFluorescenceCell membrane
The invention discloses a method for observing dynamic distribution of tumor cell exosome and exosome internal miRNA in recipient cells. The method comprises the following steps: after extracting thetumor cell exosome, conducting fluorescence labeling on a tumor cell exosome membrane and the exosome internal miRNA through an exosome membrane stain and a molecular beacon which is complementary with the exosome internal miRNA, and meanwhile, staining the recipient cells via a cell membrane stain; and implementing co-culture on the tumor cell exosome obtained from the fluorescence labeling and the stained recipient cells, adding an imaging buffer solution after an interaction of the tumor cell exosome and the recipient cells, and implementing dynamic tracing of exosome and miRNA in living cells through a super-resolution optical microscope. According to the method provided by the invention, the problem in the prior art that exosome cannot be carefully observed due to diffraction limit can be solved; and a novel technological means can be provided for researches on an exosome-mediated cancer metastasis mechanism and cancer metastasis and spread treatment.
Owner:SOUTHEAST UNIV
Fluorescent membrane intercalating probes and methods for their use
InactiveUS20030223935A1Good signalEffective mergerUltrasonic/sonic/infrasonic diagnosticsOrganic chemistryFluorescenceFar-red
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Owner:GRAY BRIAN D
Fluorescent membrane intercalating probes
InactiveUS7462347B2Ultrasonic/sonic/infrasonic diagnosticsMethine/polymethine dyesFluorescenceSide chain
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Owner:PHANOS TECH
Fluorescent membrane intercalating probes and methods for their use
ActiveUS20090304598A1Ultrasonic/sonic/infrasonic diagnosticsMethine/polymethine dyesFar-redFluorescence
The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Owner:PHANOS TECH
Fluorescent membrane intercalating probes and methods for their use
The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Owner:PHANOS TECH
Indicarmine mucosa staining agent and preparation method thereof
InactiveCN104127888AEarly treatmentNo side effectsIn-vivo testing preparationsChemical reactionTissue staining
The invention relates to an indicarmine mucosa staining agent used for endoscopic staining development, and a preparation method thereof. The indicarmine mucosa staining agent comprises 0.15-0.25wt% of indicarmine and 99.75-99.85wt% of purified water. The display of the microstructure by utilizing the difference of the color obtained after the deposition of the staining agent belongs to a physical effect and has no chemical reactions, the infection focus cannot be observed by using tissue staining, and the staining agent does not react with mucosa tissues. The staining agent is deposited on the mucosal fold, is not absorbed, does not combine with mucus, is discharged from the body through the intestinal tract, has no side effects, has no restricted theoretic use dosage, is easy to flush, and can repeatedly stain until a satisfactory effect is reached.
Owner:贵州高澄医疗器械有限公司
Fluorescent membrane intercalating probes
InactiveUS20060193780A1Ultrasonic/sonic/infrasonic diagnosticsMethine/polymethine dyesFar-redFluorescence
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably prossess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Owner:PHANOS TECH
Lactobacillus rhamnosus R7970 as well as product and application thereof
PendingCN114381407AIncrease viscosityClear boundariesMilk preparationBacteriaBiotechnologyLactobacillus rhamnosus
The invention discloses a lactobacillus rhamnosus R7970 as well as a product and application thereof. The lactobacillus rhamnosus R7970 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.22244. The lactobacillus rhamnosus R7970 is a lactobacillus rhamnosus R7970. Compared with an original strain M9, the lactobacillus rhamnosus R7970 provided by the invention has the advantages that the bacterial colony is obviously increased, the surface is smooth, the edge is neat, the capsular can be obviously observed after the capsular staining, the surface roughness is obviously increased, the smooth degree is obviously reduced, the boundary between the cell wall and the outer capsular is clear, and more capsular polysaccharide is generated; the capsular polysaccharide has higher resistance to the environment, the survival rate of the capsular polysaccharide in intestinal tracts is improved, and the capsular polysaccharide has immunocompetence; in addition, the viscosity of the fermentation liquor can be remarkably increased, and the method is extremely suitable for preparing high-viscosity fermentation products.
Owner:金华银河生物科技有限公司
Efficient anthocyanidin extraction method
InactiveCN107266409AHigh filtration precisionImprove qualityOrganic chemistryAdditive ingredientSolvent
The invention provides an efficient anthocyanidin extraction method, comprising the steps of I, crushing; II, roughly filtering; III, finely filtering; IV, concentrating; V, extracting via a solvent; VI, drying by spraying; VII, adsorbing. Anthocyanidins extracted by efficient anthocyanidin extraction method are good in stability, extraction rate and purity of functional effective ingredients are high, and system service life is long; membrane stain resistance is high, reproducibility is good, and the method is available for providing high-treatment-throughput high-stability continuous automatic production for a long time.
Owner:HEFEI XINDA MEMBRANE TECH
Coloring agent for mucous membrane of digestive tract, and preparation method and application thereof
ActiveCN111184876AShow subtle bump changesClearly identifiableLuminescence/biological staining preparationBiochemistryMucous membrane
The invention relates to the field of detection, in particular to a coloring agent for a mucous membrane of the digestive tract, and a preparation method and application thereof. The coloring agent for the mucous membrane of the digestive tract provided by the invention comprises a first coloring pigment and a second coloring pigment, wherein the first dyeing pigment comprises a blue pigment, andthe second dyeing pigment comprises a red pigment. When the coloring agent provided by the invention is used for staining, a stained color is obviously different from the color of the mucous membrane,tiny concave-convex changes of the mucous membrane can be well displayed, various raised, flat and sunken focuses and three-dimensional structures thereof are displayed, strong stereoscopic impression is presented, details in the digestive tract can be clearly recognized, focus boundaries can be clearly recognized, and the detection rate of lesions is remarkably increased. Besides, the coloring agent for the mucous membrane of the digestive tract provided by the invention is extremely easy to clean and few in residues after washing, enables an operation field to be clear, and has a relativelygood clinical application value.
Owner:沈伟 +1
Detection method for in-vitro inhibition of Th1 and Th17 by mesenchymal stem cells
InactiveCN112725274AEnhanced inhibitory effectPromote proliferation and differentiationMicrobiological testing/measurementSkeletal/connective tissue cellsLymphocyte proliferationPeripheral blood mononuclear cell
The invention relates to the technical field of stem cell biology, in particular to a detection method for in-vitro Th1 and Th17 inhibition of mesenchymal stem cells. The method comprises the following steps: 1, co-culturing mesenchymal stem cells and peripheral blood mononuclear cells; 2, carrying out fixed membrane rupture dyeing and detection. According to the detection method provided by the invention, lymphocyte proliferation and differentiation are promoted through co-culture of mesenchymal stem cells and peripheral mononuclear cells, so that the expression of the inhibition effect of the mesenchymal stem cells is promoted, and the inhibition effect is improved. According to the method, the PBMC cells obtained through co-culture are stimulated and blocked, so that factor secretion is promoted, meanwhile, inhibition and factor blocking are added for detection, so that expression of Th1 and Th17 in the PBMC cells is further promoted, expression of Th1 and Th17 obtained through detection is improved, and the inhibition effect is further improved.
Owner:华夏源(上海)生命科技有限公司
Method and apparatus for image scoring and analysis
ActiveUS9607376B2Improve accuracyImprove efficiencyImage enhancementImage analysisAnalysis methodComputer science
Methods and systems for image scoring and analysis are provided. Scored and analyzed images may include digital pathology images. Image scoring and analysis methods may include techniques to identify nuclei and determine membrane staining extent through the use of a priori models. Image scoring and analysis methods may include techniques for membrane intensity determination. Images may be scored based on an extent of membrane staining and membrane intensity.
Owner:AGILENT TECH INC
Immunohistochemical pd-l1 membrane staining pathological section image processing method, device and equipment
Owner:杭州迪英加科技有限公司 +1
Plant plasma membrane fluorescence labeling method and plasma membrane protein positioning and dynamic monitoring method
PendingCN114236136AShorten experiment timeBiological material analysisBiological testingDynamic monitoringBiochemistry
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Method and Apparatus for Image Scoring and Analysis
ActiveUS20150339818A1Improve accuracyImprove efficiencyImage enhancementImage analysisAnalysis methodComputer science
Methods and systems for image scoring and analysis are provided. Scored and analyzed images may include digital pathology images. Image scoring and analysis methods may include techniques to identify nuclei and determine membrane staining extent through the use of a priori models. Image scoring and analysis methods may include techniques for membrane intensity determination. Images may be scored based on an extent of membrane staining and membrane intensity.
Owner:AGILENT TECH INC
A kind of cryptococcal capsule staining solution and its preparation and use method
ActiveCN108676838BBright colorClear structureMicrobiological testing/measurementBiological material analysisP phosphateCryptococcus gattii
The invention discloses a cryptococcal capsular staining liquid, the raw material of which comprises the following components: methanol, phosphate buffer, Wright's dye powder, Giemsa dye powder, gum arabic and soot, the methanol and the The mixing volume ratio of the phosphate buffer is 1 / (0.5~2), and the phosphate buffer is a phosphate buffer with a pH value of 6.4~6.8; every 1000 ml of the methanol and the phosphate buffer 0.1-10 grams of the Wright's dye powder, 0.03-3 grams of the Giemsa dye powder, 2-20 grams of the gum arabic, and 2-20 grams of the soot are dispersed in the mixture. The invention makes the spores of the cryptococcus brightly colored, the internal structure of the spores is clear, and is easier to identify; the standard dyeing method has a high test success rate; India ink is not needed; the dyeing liquid has stable properties and can be stored for a long time.
Owner:马爽
Kit for staining esophageal mucosa
InactiveCN111346238AEasy diagnosisEasy to monitorLuminescence/biological staining preparationVitamin CEsophageal Squamous Dysplasia
The invention relates to a kit for staining esophageal mucosa. A staining solution used in esophageal mucosa staining by the kit is a compound iodine solution, and a neutralizing solution is a vitaminC solution. The staining solution is 20mL of the compound iodine solution and consists of iodine, potassium iodide and distilled water, wherein each milliliter of the compound iodine solution contains 0.02g iodine and 0.04g potassium iodide, the iodine content of the compound iodine solution is 2%, and the concentration of iodine is 60mg / mL. The neutralizing solution is 20mL of the vitamin C solution, wherein the vitamin C content is 2%. The invention overcomes the defect that iodine can stimulate and erode mucosa of upper digestive tracts. According to the invention, the standardization kitset comprising the compound iodine solution staining solution and vitamin C solution neutralization solution is convenient to use, can neutralize iodine staining in time, relieves discomfort symptomsof patients after iodine staining in time, and improves compliance of the patients, so that the detection rate of esophageal squamous dysplasia and canceration is greatly increased.
Owner:金多晨
Lens anterior capsule staining method for hypermature cataract surgery
ActiveCN109481141ANo drug chemical toxicityNo complicationsEye surgerySurgical veterinaryStainingBiocompatibility Testing
The invention belongs to the technical field of medicine and discloses a lens anterior capsule staining method for hypermature cataract surgery. 240 Clean-level male Wistar rats weighing 200-250 g aretaken; the rats are randomly divided into a normal control group and an experiment group; compound tropicamide eye drops are used to dilate pupils of the experiment group three times before surgery,muscular injection is performed with ketamine hydrochloride and chlorpromazine hydrochloride mixture for anesthesia before superior corneal limbus incising is performed, the anterior chamber is injected with methylthioninium chloride injection, and after the injection stays in the anterior chamber, full irrigating is performed with compound sodium chloride injection; suitable viscoelastic agent isinjected, and continuous circular capsulorhexis is performed to observe tissue contrast; capsulotomy vannas scissors are used to perform cutting and trimming before capsulorhexis is continued. Additional preparations are not required herein; using is available at any time; biocompatibility is good; no pharmaceutical chemical toxicity is caused to intraocular tissues, such as corneal endothelial cells and visual cells; residual trace can be discharged by means normal intraocular absorption or aqueous circulation; no evident complications occur.
Owner:THE AFFILIATED HOSPITAL OF QINGDAO UNIV
A kind of anti-visible light short-wave damage window film
ActiveCN112940632BPrevent shortwave damageWide applicabilityFilm/foil adhesivesMaterials sciencePhotochemistry
The invention discloses an anti-short-wave visible light damage window film, which sequentially comprises a composite refraction coating, an anti-blue light base film, a dyed adhesive layer, an anti-ultraviolet light base film, a pressure-sensitive adhesive layer and a release film from the outside to the inside. The present invention absorbs and blocks short-waves in visible light, especially blue light, cyan and violet light, through the cooperation of double-layered base films, so as to obtain a window film that can prevent short-wave damage of visible light. In addition, the present invention can also adjust the basic tone of the window film after absorbing blue-violet light through the dyed adhesive layer, making it as colorless and transparent as possible, so that the window film can be more easily and widely applied to various occasions.
Owner:JIANGSU SHUANGXING COLOR PLASTIC NEW MATERIALS
No-wash aggregation-inducible cell membrane targeting staining reagent based on purine skeleton and its preparation method and application
ActiveCN109722059BAvoid interferenceReduce distractionsStyryl dyesOrganic chemistryFluorescenceCell membrane
Disclosed in the present invention is a purine skeleton-based no-wash, aggregation-induced plasma membrane targeted staining reagent, and a preparation method and an application thereof, the present invention using a purine skeleton as a base for a plasma membrane stain, obtaining, by means of reasonable design regulating a fat-soluble end and a hydrophilic end, a purine skeleton-based plasma membrane targeted staining reagent, the reagent being capable of both rapid targeted staining and remaining on a plasma membrane for a relatively long time, benefiting long-term detection. In addition, given that the staining reagent has characteristics of an aggregation-induced compound, emitting light weakly or not emitting light in solution, and exhibiting strong fluorescence when not in solution, causing the stain to further have specific no-wash performance. The preparation method of the present invention has high yield and mild reaction conditions, and the prepared staining reagent has a large Stokes shift and high targeting.
Owner:SICHUAN UNIV
Membrane staining dyes containing phosphorescent transition metal polypyridine complexes
ActiveUS9441003B2Indium organic compoundsPreparing sample for investigationBiological cellCell membrane
The present invention is concerned with a staining dye for staining a biological cell, comprising dye molecules with a positively charged polar head group for attraction to cell membrane of the cell and for refraining the dye molecules from entering the cytoplasm, and one or more hydrophobic groups for interaction with phospholipids of the cell membrane. The dye molecules are phosphorescent transition metal polypyridine complexes having a metal center and ligands which are non-organic fluorophores.
Owner:CITY UNIVERSITY OF HONG KONG
Deep learning-based digestive tract mucosa staining detection system and method
PendingCN112861909AImprove the level of inspection and diagnosisImprove efficiencyCharacter and pattern recognitionMedical automated diagnosisRadiologyMedical institution
Owner:CHONGQING SKYFORBIO
Method for judging cytomembrane coloring integrity of her2 pathological image based on transfer learning
PendingCN113642518AGood effectCharacter and pattern recognitionNeural architecturesData setFeature extraction
The invention relates to a method for judging the cytomembrane coloring integrity of a her2 pathological image based on transfer learning, which comprises the steps of firstly, through image screening, dyeing separation and membrane coloring region division, manually dividing an image data set with completely wrapped membrane dyeing and an image data set with incomplete wrapped membrane dyeing by an expert as an input data set for Inception-V3 model training; and in the feature extraction step, firstly, training an Inception-V3 model, and then further training the Inception-V3 model through transfer learning to obtain a new classification model of the neural network. According to the method for judging the cytomembrane coloring integrity of the her2 pathological image, a neural network model with a good effect can be trained by using a small amount of training data in a short time through transfer learning, the accuracy of 92% or above can be achieved for different individuals, and effective help is provided for doctors to judge the breast cancer her2 positive state.
Owner:SHANDONG COMP SCI CENTNAT SUPERCOMP CENT IN JINAN
A kind of digestive tract mucous membrane staining agent, preparation method and application thereof
ActiveCN111184876BShow subtle bump changesClearly identifiableLuminescence/biological staining preparationStainingBiology
The invention relates to the detection field, in particular to a digestive tract mucosa stain, a preparation method and an application thereof. The digestive tract mucosa staining agent provided by the present invention includes a first dyeing pigment and a second dyeing pigment; the first dyeing pigment includes a blue pigment; and the second dyeing pigment includes a red pigment. When the digestive tract mucous membrane staining agent provided by the present invention is used for staining, it can form a clear contrast with the color of the mucous membrane itself, excellently display the subtle concave-convex changes of the mucous membrane, and display various raised, flat, sunken lesions and their three-dimensional structures, Strong three-dimensional sense, can clearly identify the details in the digestive tract, identify the boundaries of lesions, and significantly improve the detection rate of lesions. In addition, the digestive tract mucosa stain provided by the present invention is very easy to clean, has less residue after washing, and has a clear surgical field, which has good clinical application value.
Owner:沈伟 +1
A method for staining the anterior lens capsule in overmature cataract surgery
ActiveCN109481141BNo drug chemical toxicityNo complicationsEye surgerySurgical veterinaryTreatment and control groupsBiocompatibility
The invention belongs to the field of medical technology, and discloses a method for staining the anterior lens capsule in overmature cataract surgery. Take 240 clean-grade male Wistar rats with a body weight of 200-250 g; the animals are randomly divided into a normal control group and an experimental group; The experimental group was dilated with compound tropicamide eye drops three times before operation, anesthetized by intramuscular injection of a mixture of ketamine hydrochloride and chlorpromazine hydrochloride, then made an upper limbal incision, injected methylene blue injection into the anterior chamber, and stayed in the anterior chamber Afterwards, fully flush with compound sodium chloride injection; inject appropriate amount of viscoelastic agent, continuously circular capsulorhexis, observe tissue contrast; continue capsulorhexis after trimming with capsular shears. The present invention does not require additional preparation, can be taken at any time, and has good biocompatibility; it has no drug chemical toxicity to intraocular tissues, such as corneal endothelial cells and visual cells; residual traces can be discharged through normal intraocular absorption or aqueous humor circulation; no Obvious complications.
Owner:THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Medical image processing method, device, terminal and storage medium
ActiveCN114078128BImprove accuracyStrong specificityImage enhancementImage analysisImaging processingNuclear medicine
The present application provides a medical image processing method, device, terminal, and storage medium. The method includes: obtaining a segmented image of blood vessels corresponding to a stained enlarged image of esophageal background mucous membrane; obtaining a segmented image corresponding to a region lacking in blood vessels; Perform image superposition processing on the segmented image of the blood vessel area to obtain the superimposed blood vessel segmentation image; obtain the background mucosa color representation image corresponding to the esophagus background mucosa staining enlarged image; obtain the background mucosa smoothness representation image corresponding to the esophageal background mucosa staining enlargement image; and superimpose the blood vessel segmentation Image, background mucosal color representation image and background mucosa smoothness representation image are processed by channel fusion to obtain esophageal background mucosal staining enlarged composite image; based on esophageal background mucosal staining enlarged composite image, determine the esophageal markers corresponding to the esophageal background mucosal staining zoom-in image Infiltration depth. Improved accuracy of depth of invasion determination for esophageal markers.
Owner:WUHAN UNIV
Medical image processing method and device, terminal and storage medium
ActiveCN114078128AImprove accuracyStrong specificityImage enhancementImage analysisImaging processingNuclear medicine
The invention provides a medical image processing method and device, a terminal and a storage medium. The method comprises the following steps of: acquiring a blood vessel segmentation image corresponding to an esophageal background mucosa staining and magnifying image; acquiring a corresponding blood-vessel-lack region segmentation image; performing image superposition processing on the blood vessel segmentation image and the blood-vessel-lack region segmentation image to obtain a blood vessel segmentation superposed image; acquiring a background mucosa color characterization image corresponding to the esophageal background mucosa staining and magnifying image; acquiring a background mucosa flatness characterization image corresponding to the esophageal background mucosa staining and magnifying image; performing channel fusion processing on the blood vessel segmentation superposed image, the background mucosa color characterization image and the background mucosa flatness characterization image to obtain an esophageal background mucosa staining and magnifying synthetic image; and determining the infiltration depth of an esophageal marker corresponding to the esophageal background mucosa staining and magnifying image based on the esophageal background mucosa staining and magnifying synthetic image. The accuracy of determining the infiltration depth of an esophageal marker is improved.
Owner:WUHAN UNIV
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