225results about How to "Effective merger" patented technology

Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more preferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.

A portable cooler having one or more ice sheets including built-in refrigerant cubes. The cooler comprises an outer fabric shell and one or more sets of spaced apart refrigerant cubes encapsulated in plastic to form ice sheets that are attached to the interior walls of the cooler. The walls of the cooler may also include one or more layers of thermal insulation. The ice sheets provide a visually pleasing appearance to the inside of the cooler suggestive of cooling effects. The ice sheets may be retained along the walls of the cooler by seams sewn along the lanes passing between the refrigerant cubes, by being retained in pockets formed by sidewall liners or by being secured into chambers defined by the cooler's outer walls and a plastic insert fitted into the cooler. The cooler may include a hinged top and bottom that can be folded flat for allowing the cooler to assume a compact configuration during storage or freezing of the refrigerant cubes.

The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may posses both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used in any application including, but not limited to, DNA sequencing reactions, amplification reactions, cDNA synthesis reactions, and combined cDNA synthesis and amplification reactions, e.g., RT-PCR.

An optical and/or optoelectrical transceiver and system are disclosed that enable parallel transmission of data and management signals via an optical fiber without affecting data signal transmissions transmitted on the optical fiber. Furthermore, the present transceiver and system provide a fault diagnosis function for an optical fiber link. The transceiver and system generally comprise an interface, an intersecting transmission management unit, a driver, a management signal driving unit, an optical transmitter, an optical receiver, an amplifier, a management signal recovery unit, a management unit, and optionally, a power supply unit.

A distributed historian framework is provided where historical data is collected in accordance with an organizational model of a hierarchical system that is distributed across various elements of an enterprise. A directory service operates with the organizational model to enable configuration of historian components within the organization and to enable data to be located within the organization. In one aspect, an industrial automation system is provided. The system includes at least one historian component to archive data within an organization. A common data model then exposes functionality and data of the organization to the historian component.

A portable cooler having one or more ice sheets including built-in refrigerant cubes. The cooler comprises an outer fabric shell and one or more sets of spaced apart refrigerant cubes encapsulated in plastic to form ice sheets that are attached to the interior walls of the cooler. The walls of the cooler may also include one or more layers of thermal insulation. The ice sheets provide a visually pleasing appearance to the inside of the cooler suggestive of cooling effects. The ice sheets may be retained along the walls of the cooler by seams sewn along the lanes passing between the refrigerant cubes, by being retained in pockets formed by sidewall liners or be being secured into chambers defined by the cooler's outer walls and a plastic insert fitted into the cooler.

The invention provides an audio and video combined teaching and training system and a realization method. Belonging to the teaching instrument field, the invention relates to a training system applied to teaching and the using method of the system. The system mainly includes: a teacher's audio and video recording device consisting of a teacher camera and a teacher adapter; a student's audio and video recording device consisting of a student camera and a student adaptor; an ID identifier for identifying the ID of personnel; a host including a memorizer for storing data and operating programs, and a processor as well as a display. The invention has the advantages that by the invention, users can comprehensively record information in teaching, effectively combine various data flows, and display the process and details of teaching to improve the teaching effect.

The invention discloses a method for storing transmission line integrated data based on HBase. The method comprises the steps of collecting the transmission line integrated data, wherein the transmission line integrated data comprise structural data and unstructured data; classifying the transmission line integrated data; building an Hbase table according to the classifying result; converting the transmission line integrated data in the Hbase table as byte arrays; sequentially storing the byte arrays into an HBase distributed database according to the format of the Hbase table, wherein the HBase distributed database is built on an HDFS (Hadoop Distributed File System). By adopting the method, the transmission line integrated data can be integrated with the HDFS and HBase; the problems that the original data are poor in information sharing, the information is in isolated island, and the unstructured data are difficult to process can be solved.

A method for making a layered material can include providing a substrate having a surface with at least one region having a charge and forming layers by sequentially contacting the at least one region with a first solution and a second solution. The first solution comprises a first layering material in an ionic liquid and the second solution comprises a second layering material in a second ionic solution. The first and second layering materials can have a chemical affinity to each other. The first layering material and/or the second layering material can include polyelectrolytes, polymers, carbon nanotubes, or combinations thereof.

The present invention describes an intercalated clay intercalated with a polyether block polyamide copolymer. An article is included comprising a matrix polymer and an intercalated clay comprising clay intercalated with polyether block polyamide copolymer. The present invention also includes an article comprising polyether block polyamide copolymer and intercalated clay.

The present invention is drawn to a method for characterising nucleic acid molecules, which comprises the steps of: i) introducing a modified base which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base with the DNA glycosylase to generate an abasic site; iii) cleaving the DNA at the abasic site to generate and release an extendible upstream DNA fragment having a 3′ hydroxyl terminus; and iv) incubating the released extendible upstream DNA fragment in the presence of an enzyme allowing for extension thereof and an additional template nucleic acid and analysing resultant fragment(s).