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Indicarmine mucosa staining agent and preparation method thereof

A technology for indigo carmine and dyeing agent, applied in the field of indigo carmine mucosal dye and preparation thereof, can solve the problems of reduced urine output, side effects, inability to display pit structure and the like, and achieves the effects of easy washing and satisfactory effect.

Inactive Publication Date: 2014-11-05
贵州高澄医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methylene blue also has some disadvantages in clinical application as a mucosal stain: (1) it cannot display pits (specialized vesicular invaginations on the surface of the cell membrane) and pit structures; (2) staining is not satisfactory and needs to be re-stained (3) Absorbed into the blood by epithelial cells and produce side effects: after absorption, the hemoglobin in the human body can be converted into methyl hemoglobin, and part of it can be absorbed and excreted in the urine, lasting about 2 days, accompanied by dysuria and dysuria. It can also cause symptoms such as nausea, abdominal pain or urticaria, and a large amount of application can lead to acute liver and renal insufficiency

Method used

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  • Indicarmine mucosa staining agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 0.2kg of indigo carmine and add it to 99.8kg of purified water, mix evenly, and fill to obtain an indigo carmine mucosal staining agent with a specification of 15ml, 20ml or 50ml.

Embodiment 2

[0018] Weigh 0.25 kg of indigo carmine and add it to 99.85 kg of purified water, mix well, and fill to obtain an indigo carmine mucosal staining agent with a specification of 15 ml, 20 ml or 50 ml.

Embodiment 3

[0020] Weigh 0.15 kg of indigo carmine and add it to 99.75 kg of purified water, mix evenly, and fill to obtain an indigo carmine mucosal stain with a specification of 15 ml, 20 ml or 50 ml.

[0021] In order to illustrate the beneficial effects of the present application, the following tests are specially made:

[0022]

[0023] When using the indigo carmine mucosa staining agent of the present invention, under the monitoring of the endoscope, the dyeing agent is spread to the parts of the digestive tract (such as stomach, intestine, etc.) Observe the pathology of the stained part directly with the speculum. The dosage at one time is 5-50ml, generally no more than 60ml. When storing, the humidity should not exceed 80%, in a cool, dry, well-ventilated, non-corrosive gas, and clean environment.

[0024] Through comparative experiments, it was found that when the content of indigo carmine was ≥ 2.5%, the contrast with the orange-red mucous membrane decreased significantly, ...

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PUM

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Abstract

The invention relates to an indicarmine mucosa staining agent used for endoscopic staining development, and a preparation method thereof. The indicarmine mucosa staining agent comprises 0.15-0.25wt% of indicarmine and 99.75-99.85wt% of purified water. The display of the microstructure by utilizing the difference of the color obtained after the deposition of the staining agent belongs to a physical effect and has no chemical reactions, the infection focus cannot be observed by using tissue staining, and the staining agent does not react with mucosa tissues. The staining agent is deposited on the mucosal fold, is not absorbed, does not combine with mucus, is discharged from the body through the intestinal tract, has no side effects, has no restricted theoretic use dosage, is easy to flush, and can repeatedly stain until a satisfactory effect is reached.

Description

technical field [0001] The invention relates to an indigo carmine mucosa staining agent for endoscope staining and development and a preparation method thereof. Background technique [0002] The surface of the normal gastrointestinal mucosa is smooth, but when there are minor lesions, such as ulcers, cancer, etc., the surface will change, but usually without obvious clinical symptoms, due to the small changes, coupled with the resolution and Due to the limitation of contrast, in clinical practice, there are still great difficulties in the mucosal changes of early lesions. [0003] The introduction of chromoendoscopy technology has solved this problem very well. Chromoendoscopy technology refers to the use of mucosal dyes on the basis of routine endoscopy to increase the contrast between lesions and normal tissues and enhance the fine bumps on the mucosal surface. The three-dimensional sense makes the shape and scope of the lesion clearer, thereby improving the ability of na...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 曹云晃兵郎涛
Owner 贵州高澄医疗器械有限公司
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