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Immunohistochemical pd-l1 membrane staining pathological section image processing method, device and equipment

A PD-L1, immunohistochemical technology, applied in image data processing, image analysis, image enhancement, etc., can solve the problems of pathologists' time-consuming, difficult and suspicious tissue area identification, etc., and achieve good interpretability.

Active Publication Date: 2021-06-08
杭州迪英加科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, for the analysis of immunohistochemical PD-L1 (SP263) membrane stained section images, there are many challenges that make the work of pathologists difficult and time-consuming. Efficiently and accurately identify suspicious tissue areas

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  • Immunohistochemical pd-l1 membrane staining pathological section image processing method, device and equipment
  • Immunohistochemical pd-l1 membrane staining pathological section image processing method, device and equipment
  • Immunohistochemical pd-l1 membrane staining pathological section image processing method, device and equipment

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Embodiment Construction

[0032] Hereinafter, exemplary embodiments of the present application will be described in detail with reference to the accompanying drawings. Apparently, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments of the present application. It should be understood that the present application is not limited by the exemplary embodiments described here.

[0033] Application overview

[0034] Currently, the immunohistochemical method for PD-L1 (SP263) membrane staining section analysis is as follows:

[0035] 1) Divide the slice into four partitions, and interpret and count the tumor cells in each partition;

[0036] 2) Interpret the positive tumor cells and negative tumor cells in each partition, in which the linear brown cell membrane staining (partial or complete) of the positive tumor cells can be seen, and the cell membrane of the negative tumor cells has no staining, only the cytoplasm staining;

[0037] 3) Any i...

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Abstract

The invention relates to an image processing method, device and equipment for immunohistochemical PD‑L1 membrane staining pathological sections. The image processing method includes: obtaining the full-field image of the digital slice of the immunohistochemical PD‑L1 (SP263) membrane stained pathological section to be diagnosed; using the region segmentation network to analyze the tumor cells in the full-field image of the digital slice under the magnification of the first field of view. The area is identified and segmented to obtain the tumor cell area probability map of the entire digital slice full-field map; the cells in each digital slice full-field map are identified and segmented, and the cell location network is evaluated using the tumor cell area probability map as a weight matrix. Regional constraints, identifying cell features on the full-field map of digital slices, positioning and classifying various types of cells on the full-field map of digital slices; marking the cell position, cell type and immunohistochemical PD‑ on the full-field map of digital slices L1 (SP263) indicator. This application designs a multi-level feature collaborative diagnosis strategy and uses regional features to constrain cell features to accurately evaluate tumor proportion scores.

Description

technical field [0001] The present invention relates to the field of pathological image processing, in particular to an immunohistochemical PD-L1 membrane staining pathological section image processing method, device, equipment and computer-readable storage medium. Background technique [0002] With the development of pathological diagnostic technology and molecular biomedicine in recent years, the Department of Pathology has shown an unprecedented development momentum. Currently, pathological diagnosis is the gold standard for tumor diagnosis. Pathologists provide evidence for the final diagnosis by analyzing pathological slides, making pathological diagnosis an indispensable part of tumor treatment. As a key technology of histopathology or cytopathology, immunohistochemistry technology is one of the key technologies in the current process of tumor interpretation, diagnosis and treatment, and has great influence. [0003] The so-called immunohistochemical technique or immu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/00G06T7/11G06T3/40G06N3/04G06N3/08
CPCG06T7/0012G06T7/11G06T3/4038G06N3/08G06T2207/30024G06T2207/30096G06T2207/20221G06T2207/20081G06T2207/20084G06N3/045
Inventor 杨林亢宇鑫李涵生崔磊费达付士军徐黎杨海英
Owner 杭州迪英加科技有限公司
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