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Coloring agent for mucous membrane of digestive tract, and preparation method and application thereof

A technology of digestive tract and dyeing agent, applied in the detection field, can solve the problems of strong visual perception drop, blurred surgical field, difficult cleaning, etc., and achieve the effect of strong three-dimensional effect, improved dyeing effect, and easy cleaning

Active Publication Date: 2020-05-22
沈伟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, indigo carmine is blue and has a large color difference with the color of the digestive tract mucosa (close to pink to white). After dyeing, the visual gap is too strong, which may easily cause blurred surgical field and is not easy to clean.
[0008] In short, due to the design defects of the existing gastrointestinal mucosa stains, there are some shortcomings in the application. The market urgently needs a stain that has obvious staining effects, is safe and effective, and does not affect the surgical field.

Method used

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  • Coloring agent for mucous membrane of digestive tract, and preparation method and application thereof
  • Coloring agent for mucous membrane of digestive tract, and preparation method and application thereof
  • Coloring agent for mucous membrane of digestive tract, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-16

[0061] The composition of the digestive tract mucosal stain provided in Examples 1-16 is shown in Table 1 respectively;

[0062] The components shown in Table 1 were respectively dissolved in 100 mL of purified water to obtain the aqueous solution of the digestive tract mucosal stain of Examples 1-16.

[0063] Among them, when actually preparing the digestive tract mucosa stain, the added quality of each component can be adjusted according to the mass ratio of each component shown in Table 1.

[0064] In the aqueous solution of the digestive tract mucosal stain provided in Examples 1-16, the total mass concentration of the first staining pigment and the second staining pigment is 0.22%. In actual use, the total mass concentration of the first coloring pigment and the second coloring pigment in the aqueous solution of the digestive tract mucosal stain can be in the range of 0.01-1%, preferably 0.05-0.5%, more preferably 0.15-0.25% .

[0065] Table 1

[0066]

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Abstract

The invention relates to the field of detection, in particular to a coloring agent for a mucous membrane of the digestive tract, and a preparation method and application thereof. The coloring agent for the mucous membrane of the digestive tract provided by the invention comprises a first coloring pigment and a second coloring pigment, wherein the first dyeing pigment comprises a blue pigment, andthe second dyeing pigment comprises a red pigment. When the coloring agent provided by the invention is used for staining, a stained color is obviously different from the color of the mucous membrane,tiny concave-convex changes of the mucous membrane can be well displayed, various raised, flat and sunken focuses and three-dimensional structures thereof are displayed, strong stereoscopic impression is presented, details in the digestive tract can be clearly recognized, focus boundaries can be clearly recognized, and the detection rate of lesions is remarkably increased. Besides, the coloring agent for the mucous membrane of the digestive tract provided by the invention is extremely easy to clean and few in residues after washing, enables an operation field to be clear, and has a relativelygood clinical application value.

Description

Technical field [0001] The invention relates to the field of detection, in particular to a digestive tract mucosal stain, a preparation method and application thereof. Background technique [0002] Gastrointestinal diseases are common diseases that endanger human health. In severe cases, they can even cause death. Among them, the incidence and mortality of gastric cancer are among the top cancers in the world. The prognosis of gastrointestinal diseases is directly related to the diagnosis stage. The key to reducing the mortality of gastrointestinal diseases lies in early diagnosis and treatment. At present, endoscopy is the accepted method of choice in the examination and diagnosis of gastrointestinal diseases. The smooth surface of the normal gastrointestinal mucosa is observed under endoscopy, and the gastrointestinal mucosa surface changes when there is a disease. However, many cases have found that for some early gastrointestinal diseases, it is difficult to correctly judge ...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/006
Inventor 张建国沈伟刘晓臣苏洋徐景海
Owner 沈伟
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