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A kind of digestive tract mucous membrane staining agent, preparation method and application thereof

A technology for digestive tract and dyeing agent, applied in the field of detection, can solve the problems of strong visual perception drop, blurred surgical field, and difficult cleaning, etc., and achieves the effect of strong stereoscopic effect, improved dyeing effect, and easy cleaning.

Active Publication Date: 2022-03-04
沈伟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, indigo carmine is blue and has a large color difference with the color of the digestive tract mucosa (close to pink to white). After dyeing, the visual gap is too strong, which may easily cause blurred surgical field and is not easy to clean.
[0008] In short, due to the design defects of the existing gastrointestinal mucosa stains, there are some shortcomings in the application. The market urgently needs a stain that has obvious staining effects, is safe and effective, and does not affect the surgical field.

Method used

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  • A kind of digestive tract mucous membrane staining agent, preparation method and application thereof
  • A kind of digestive tract mucous membrane staining agent, preparation method and application thereof
  • A kind of digestive tract mucous membrane staining agent, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-16

[0061] The compositions of the digestive tract mucosa stains provided in Examples 1-16 are shown in Table 1 respectively;

[0062] The components shown in Table 1 were respectively dissolved into 100 mL of purified water to obtain the aqueous solutions of the digestive tract mucosa stains of Examples 1-16.

[0063] Wherein, when actually preparing the digestive tract mucosa stain, the added mass of each component can be adjusted according to the mass ratio of each component shown in Table 1.

[0064] In the aqueous solution of the digestive tract mucosa staining agent provided in Examples 1-16, the total mass concentration of the first dyeing pigment and the second dyeing pigment is 0.22%. In actual use, the total mass concentration of the first dyeing pigment and the second dyeing pigment in the aqueous solution of the digestive tract mucosa staining agent can be within the range of 0.01-1%, preferably 0.05-0.5%, more preferably 0.15-0.25% .

[0065] Table 1

[0066]

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PUM

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Abstract

The invention relates to the detection field, in particular to a digestive tract mucosa stain, a preparation method and an application thereof. The digestive tract mucosa staining agent provided by the present invention includes a first dyeing pigment and a second dyeing pigment; the first dyeing pigment includes a blue pigment; and the second dyeing pigment includes a red pigment. When the digestive tract mucous membrane staining agent provided by the present invention is used for staining, it can form a clear contrast with the color of the mucous membrane itself, excellently display the subtle concave-convex changes of the mucous membrane, and display various raised, flat, sunken lesions and their three-dimensional structures, Strong three-dimensional sense, can clearly identify the details in the digestive tract, identify the boundaries of lesions, and significantly improve the detection rate of lesions. In addition, the digestive tract mucosa stain provided by the present invention is very easy to clean, has less residue after washing, and has a clear surgical field, which has good clinical application value.

Description

technical field [0001] The invention relates to the detection field, in particular to a digestive tract mucosa stain, a preparation method and an application thereof. Background technique [0002] Gastrointestinal diseases are common diseases that endanger human health, and even cause death in severe cases. Among them, the incidence and mortality of gastric cancer rank among the forefront of cancers in the world. The prognosis of gastrointestinal diseases is directly related to the diagnosis stage, and the key to reducing the mortality of gastrointestinal diseases lies in early diagnosis and treatment. At present, endoscopic examination is recognized as the preferred method in the examination and diagnosis of gastrointestinal diseases. The surface of normal gastrointestinal mucosa is smooth when observed under endoscopy. When there are lesions, the surface of gastrointestinal mucosa changes. However, it has been found in many cases that for some early gastrointestinal disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00
CPCA61K49/006
Inventor 张建国沈伟刘晓臣苏洋徐景海
Owner 沈伟
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