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48 results about "Lactose Powder" patented technology

Method for increasing lactose tolerance in mammals exhibiting lactose intolerance

InactiveUS7029702B2Increasing lactose toleranceImprove toleranceOrganic active ingredientsBiocideTolerabilityMammal
The method for increasing lactose tolerance in subjects exhibiting lactose intolerance symptoms implements a protocol where the subjects ingest a gradually increasing amount of lactose containing product over a six week period. At various points during the six week period the subject ingests the lactose containing product once a day and then twice a day. The lactose containing product can be in liquid form, such as for example, milk, and is preferably in a powder form which is taken either by ingesting capsules having the lactose powder or in a granular form mixed with water or other non-lactose containing liquid. At the end of the six week period, the subject's tolerance for lactose containing products is substantially increased, with the potential of eliminating the subject's lactose intolerant behavior indefinitely.
Owner:RITTER PHARMA

Infant formula milk powder and preparation method thereof

The present invention relates to an infant formula milk powder capable of preventing and alleviating infant iron deficiency anemia and a preparation method thereof. The formula milk powder comprises components such as vegetable oil, fresh milk, whey powder, lactose powder, whey protein powder, oligosaccharides, complex vitamins and complex minerals, wherein the lactoferrin and vitamin C, or alternatively, an iron source (calculated as iron), lactoferrin and vitamin C are maintained in the appropriate mass ratios, and the formula milk powder of the present invention is obtained by performing mixing, homogenizing, cooling, concentrating and spray-drying, packaging or directly using a step-by-step mixing method. The formula milk powder comprises appropriate amounts of vitamin C and lactoferrin, as well as an appropriate amount of iron source as further provided, and the three are combined according to an appropriate proportion, so that the combination of the three kinds of the substances have a synergistic effect, and the absorption and utilization rate of iron are increased dramatically, thereby not only achieving the desirable iron supplementation effect, but also preventing and alleviating the phenomenon of infant iron deficiency anemia.
Owner:ZHEJIANG CONBA HEALTH PROD

Granulated dairy products

The invention concerns a granulated dairy product that includes particles of milk powder along with dry particles selected from dried emulsified fat particles, whey protein isolates, maltodextrines, starches and sucrose or lactose powders. The milk powder and dry particles are agglomerated together and are at least partially coated with a binding medium that includes a carbohydrate to form coated agglomerate particles having a mean particle diameter of between 10 and 10000 μm.
Owner:NESTEC SA

Method for increasing lactose tolerance in mammals exhibiting lactose intolerance

The method for increasing lactose tolerance in subjects exhibiting lactose intolerance symptoms implements a protocol where the subjects ingest a gradually increasing amount of lactose containing product over a six week period. At various points during the six week period the subject ingests the lactose containing product once a day and then twice a day. The lactose containing product can be in liquid form, such as for example, milk, and is preferably in a powder form which is taken either by ingesting capsules having the lactose powder or in a granular form mixed with water or other non-lactose containing liquid. At the end of the six week period, the subject's tolerance for lactose containing products is substantially increased, with the potential of eliminating the subject's lactose intolerant behavior indefinitely.
Owner:RITTER PHARMA

Infant formula milk powder and preparation method thereof

The invention relates to an infant formula milk powder which can be used for preventing and improving iron-deficiency anemia of infants and a preparation method of the infant formula milk powder. The infant formula milk powder comprises the following components of vegetable oil, fresh milk, whey powder, lactose powder, whey protein powder, oligosaccharide, compound vitamin and compound mineral substances and the like; suitable mass ratio of lactoferrin to vitamin C or an iron source (measuring in iron) to the lactoferrin and the vitamin C is kept; and the formula milk powder is obtained by adopting mixing, homogenizing, cooling, concentrating, spray-drying and packaging or directly adopting a step-by-step mixing method. As proper amount of vitamin C and lactoferrin are contained in the formula milk powder, moreover, proper amount of the iron source is added, and the the vitamin C, the lactoferrin and the iron source are combined at a proper ratio, so that the three substances can exert the synergistic effect; and the absorption utilization rate of the iron is greatly improved, not only is the iron supplementing effect good, but also the phenomenon of the iron-deficiency anemia of the infants can be prevented and improved.
Owner:HANGZHOU QIANDAOHU KANGNUOBANG HEALTH PROD CO LTD

Method for preparing whey protein powder (WPC) and lactose powder simultaneously by whey

The invention belongs to a production technology of a dairy product and particularly relates to a method for preparing WPC and lactose powder simultaneously by whey. The main steps are as follows: (1) primary ultrafiltration: a whey solution passes through an ultrafiltration membrane with the molecular weight cutoff of 5,000 to 10,000Da; (2) moisturization and ultrafiltration: when the membrane flux is reduced to 60% to 80% of the primary membrane flux, continuously supplementing 2 to 5 times of deionized water based on the volume of a concentrated solution into the concentrated solution to obtain a permeate and the concentrated solution; (3) preparing the whey protein powder: ultrafiltrating and drying the whey protein powder to obtain the WPC; and (4) refining the lactose powder: adding the evaporated and condensed ultrafiltration permeate into food grade ethanol till the final volume fraction is 40 to 60%, collecting, washing and drying the precipitate to obtain the lactose. According to the method for preparing the WPC and the lactose powder simultaneously by the whey, WPC with high protein content and lactose powder with high purity are obtained simultaneously through the ultrafiltration as a main separating method, and the deionized water and the food grade ethanol are only added in the whole process but the substances including external salt, acid and alkali and the like are not added.
Owner:ZHEJIANG UNIV

A biological agent for improving human body intestinal floras and a preparing method thereof

The invention relates to a biological agent for improving human body intestinal floras and a preparing method thereof. The biological agent comprises 45-68 parts by weight of lactic acid bacteria, 30-50 parts by weight of isomerized lactose powder, 20-50 parts by weight of apple vinegar, 30-50 parts by weight of ferment and 10-30 parts by weight of dietary fiber. The biological agent is prepared by fully mixing the acetic acid bacteria, the apple vinegar and the dietary fiber by stirring, adding the isomerized lactose powder and the ferment, continuously stirring and mixing for 30-45 min, and sterilizing. Compared with the prior art, the biological agent is simple in composition and is capable of effectively promoting increase of bifidobacteria which are beneficial bacteria in intestinal tracts, allowing the lactic acid bacteria and the bifidobacteria to increase in a balance manner and inhibiting growth of putrefying bacteria and pathogenic bacteria, thus effectively balancing beneficial floras in the intestinal tracts. The biological agent is simple in preparing process, rapid in production of desired effects, wide in suitable population, low in medicine using amount, less in side effects, high in stability, long in shelf life, convenient in medicine taking, easy to carry, low in cost and suitable for large-scale production.
Owner:上海善力健生物科技有限公司

Milk tea tablet and production process thereof

The invention discloses a milk tea tablet. The milk tea tablet is prepared from raw material in parts by weight: 10-14 parts of whole milk powder, 0.4-1.5 parts of black tea powder, 3-8 parts of sucrose powder, 3-15 parts of lactose powder, 0.2-0.5 part of sodium carboxymethyl cellulose, 0.0001-0.03 part of ethyl maltol, and 1-4 parts of corn starch. The invention also discloses a process for producing the milk tea tablet. The instant milk tea tablet has rich milk tea flavor, mellow mouth feeling, and moderate saccharinity; and the milk tea tablet prepared by the prescription is difficult to disintegrate, has stable structure, can be directly eaten or brewed to drink, and is an ideal leisure food. Meanwhile, the consumer can add coffee powder or chocolate powder and the like into the milk tea according to personal taste to form corresponding flavor milk tea.
Owner:ZHEJIANG UNIV

Capsule type tiotropium bromide inhalation powder

The present invention discloses one kind of tiotropium bromide capsule atomized powder preparation, which includes tiotropium bromide or tiotropium bromide monohydrate in 0.04-1.5 wt% and fine lactose powder of size smaller than 15 microns for adsorbing tiotropium bromide or tiotropium bromide monohydrate. The present invention also provides the preparation process of the atomized powder preparation. The tiotropium bromide capsule atomized powder preparation has simple preparation process, excellent flowability and homogeneously distributed active component.
Owner:NANJING CAVENDISH BIO ENG TECH +1

Production method of sugarless fermented whey beverage

The invention provides a production method of sugarless fermented whey beverage. The method comprises the following steps: mixing whey powder and lactose powder, adding hot purified water, dissolving, boiling to sterilize, cooling, inoculating lactic acid bacteria, allowing fermentation, inoculating lactobacilli, allowing secondary fermentation, and chilling; mixing CMC and healthy sugar, dissolving in hot water and cooling; and mixing the resulting two mixtures, vigorously stirring, flavoring, supplementing water to the desired volume, homogenizing, sterilizing, and packaging under sterile conditions to obtain milk white sugarless fermented whey beverage. The sugarless fermented whey beverage can be preserved at 4 DEG C for about 7 days.
Owner:苏州工业园区尚融科技有限公司

Cheese-coated food product

The present invention relates to the preparation of food products presented in the form of a bite-sized piece comprising a cereal-based core and a cheese coating. Said cheese snack is characterised in that it comprises a pre-layer coating positioned between the central part and the cheese coating layer; said pre-layer comprises a mixture of fatty substance having a melting point of between 30 and 34 DEG C and lactose powder; it is spherical in shape and its surface is smooth.
Owner:保健然有限公司

Preparation method of olanzapine orally disintegrating tablet for treating depression

The invention discloses a preparation method of an olanzapine orally disintegrating tablet for treating depression and belongs to the field of pharmaceutical preparations. The preparation method of the olanzapine orally disintegrating tablet for treating depression comprises the following steps: smashing a binding agent, olanzapine, phospholipids, a disintegrating agent, a flavouring agent, a lubricating agent, mannitol and lactose, and sieving; dissolving the binding agent into water; then adding olanzapine, phospholipids and a filing agent into a fluidized bed, spraying binding agent solution into the fluidized bed for pelletizing, and drying after pelletizing is finished; and mixing the dried particles with the disinterring agent, the flavouring agent, the lubricating agent, mannitol and lactose, and then tabletting, thus obtaining the olanzapine orally disintegrating tablet. The preparation method of the olanzapine orally disintegrating tablet for treating depression has the advantages that olanzapine, phospholipids and the filling agent are coated by the binding agent in advance and then are mixed with other auxiliary materials, and tabletting is carried out, and thus disintegrating rate and breakage rate of the orally disintegrating tablet are effectively increased, stability of the tablet after long-term storage is well improved, and content of related substances is low.
Owner:刘新刚 +1

Prulifloxacin composition and preparation method thereof, and synthesis method of raw material drugs

ActiveCN101711763AThe synthesis method is reasonableHigh content of prulifloxacinAntibacterial agentsOrganic active ingredientsSynthesis methodsDissolution
The invention discloses a Prulifloxacin composition. The composition comprises the following components: 130 to 135 parts of Prulifloxacin, 35 to 45 parts of lactose, 9 to 10 parts of hydroxypropyl cellulose, 1.5 to 2.5 parts of magnesium stearate and 15 to 20 parts of povidone K30. Quality and yield of the Prulifloxacin are greatly improved by adjusting parameters during synthesis, such as addition speed of reactants. The method for preparing the composition comprises the following steps of preparing solution of povidone K30 ethanol; uniformly mixing the Prulifloxacin with the hydroxypropyl cellulose, and crushing the mixture with mechanical crusher; screening, and screening crushed lactose; adding lactose into mixed powder of the Prulifloxacin and the hydroxypropyl cellulose, and uniformly mixing with a three-dimensional mixer; then adding the prepared solution of povidone K30; uniformly mixing, granulating, and straightening granules after drying; and adding the magnesium stearate into the prepared granules and uniformly mixing with the three-dimensional mixer. The composition prepared by the method has advantages of good quality, less disintegration time and high dissolution efficiency.
Owner:SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD

Method for extracting lactose powder from milk whey

The invention discloses a method for extracting lactose powder from milk whey. The method comprises steps as follows: step 1), fresh milk is subjected to first centrifugation, and skim milk is obtained; step 2), the milk is subjected to second centrifugation, and whey is obtained; the whey passes through a first ultrafiltration membrane under second pressure, and first permeate after the whey passes through the first ultrafiltration membrane is obtained; step 3), an acetate-sodium acetate solution is added to the first permeate; step 4), second permeate is dropwise added to 0.1wt%-5wt% of a sodium hydroxide solution, a mixed solution obtained after 15 min is subjected to filter pressing by a plate-and-frame filter press, first retentate is obtained on a filter screen and is dissolved in 0.08wt%-1.6wt% of a hydrochloric acid solution, a mixed solution obtained after 2 h passes through a nanofiltration membrane under third pressure, and fourth permeate is obtained; step 5), the fourth permeate is subjected to spray drying, and the lactose powder is obtained. With the adoption of the method, the technical problems that the lactose is difficult to extract and the extraction purity is not high are solved.
Owner:NEW HOPE SHUANGXI DAIRY SUZHOU CO LTD

Blueberry fruit vinegar beverage good for improving human intestinal environment and promoting health and preparation method of blueberry fruit vinegar beverage

The invention discloses a blueberry fruit vinegar beverage good for improving human intestinal environment and promoting health. The blueberry fruit vinegar beverage is prepared from the following components in parts by weight: 145-150 parts of fresh and intact blueberry fruits, 140-145 parts of fresh and intact taxus chinensis fruits, 5-6 parts of stachyose, 11-12 parts of Se-enriched yeast, 14-15 parts of acetic acid bacteria, 9-10 parts of ester-production yeast, 4-5 parts of fungus polyphenol, 6-7 parts of isomerized lactose powder, 7-8 parts of seaweed enzymes, 5-6 parts of inulin, 5-6 parts of L-Arabinose, 5-6 parts of polydextrose and the like. The composite fruit vinegar beverage is prepared from nutritious taxus chinensis fruits and blueberry fruits prepared concentrated compound juice, pomace fermentation products and nutritional enhancement substances, is rich in nutrients such as amino acids, vitamins and the like, has higher nutritional value, can cooperate with the nutritional enhancement substances to promote rapid reproduction of useful intestine bacteria and accelerate intestinal peristalsis, and toxic metabolites in the intestine are discharged rapidly, therefore, effects of improving the human intestinal environment and promoting health are realized.
Owner:安徽天乾健食品科技有限公司

Method for extracting high-nutrient lactose from fresh milk

The invention discloses a method for extracting high-nutrient lactose from fresh milk, which comprises the following steps: 1) carrying out primary centrifugal operation on fresh milk to obtain skimmed milk; 2) carrying out microfiltration and secondary centrifugal operation to obtain milk serum, and carrying out ultrafiltration to obtain a first filtrate which passes through a first ultrafiltration membrane; 3) adding a chitosan-acetic acid solution into the first filtrate, and carrying out secondary ultrafiltration to obtain a second filtrate; 4) dropwisely adding the second filtrate into a 0.1-5 wt% sodium hydroxide solution, carrying out pressure filtration to obtain a first retention substance on the filter screen, dissolving the first retention substance in a 0.08-1.6 wt% hydrochloric acid solution, and carrying out nanofiltration to obtain a fourth filtrate; and 5) adding calcium chloride into the fourth filtrate solution, carrying out nanofiltration to obtain a fifth filtrate, and carrying out spray drying on the fifth filtrate solution to obtain lactose powder. The method solves the technical problem of difficulty in extraction due to the loss of the high-nutrient lactose.
Owner:NEW HOPE SHUANGXI DAIRY SUZHOU CO LTD

Concentrate lactose solution and preparation method thereof

The invention provides a method for preparing a lactose solution. The method for preparing the lactose solution comprises the following steps: preparing skim milk; carrying out ultra-filtration; carrying out nano-filtration; carrying out primary ion exchange; carrying out electrodialysis; carrying out secondary ion exchange; and carrying out activated carbon decolorization. The method for preparing the lactose solution can be used for producing the lactose solution; and the produced lactose solution can be processed into lactose powder.
Owner:INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD

Sulfadimidine microcapsules and preparation method thereof

The invention discloses sulfadimidine microcapsules which comprise the following components in parts by weight: 10-20 parts of sulfadimidine, 6-12 parts of rosin, 8-10 parts of crystalline lactose powder, 4-8 parts of glucosan, 6-10 parts of disodium stannous citrate and 20-30 parts of deionized water. The sulfadimidine microcapsules disclosed by the invention have the beneficial effects that theadded crystalline lactose powder is capable of promoting preforming of a capsule wall material, the prepared sulfadimidine microcapsule has the specified shape, repeated agglomeration is not needed, the rosin and disodium stannous citrate are capable of accelerating agglomeration and solidification of the microcapsules, the reaction time is shortened, and stable microcapsules are formed.
Owner:铜陵市宏达家电有限责任公司

Production formula and technology of high-treatment-effect cyproheptadine hydrochloride tablets

The invention belongs to the field of medicines, and particularly discloses a production formula and technology of high-treatment-effect cyproheptadine hydrochloride tablets. The formula comprises thefollowing components in compounding ratio of 2g of cyproheptadine hydrochloride, 50-60g of lactose, 18-22g of starch, 2-2.5g of cellulose and 0.9-1.1g of magnesium stearate. The technology comprisesthe specific steps of S1, adding the cyproheptadine hydrochloride raw material in a micronizing machine set, performing micronizing, and crushing lactose; S2, performing mixing: mixing the obtained cyproheptadine hydrochloride with the lactose and the starch to obtain a mixture, and adding the mixture in a boiling pelletizer; S3, preparing an adhesive; S4, performing granulation; S5, shaping granules; S6, performing total mixing; and S7, performing tabletting and bottling. Production is performed based on a boiling-over granulation making technology, through disintegration characteristics of different auxiliary materials, the disintegration speed of medicines in different environment of bodies is controlled, blood medicine level in human bodies when the medicines are released in the humanbodies is consistent with that of original medicines, the production flow is simplified, besides, the product quality is improved, the release speed of main medicines is controlled, and the medicationsafety is guaranteed.
Owner:上海复旦复华药业有限公司

Lactose powder bed three dimensional printing

Disclosed is the 3D printing of pharmaceutical formulations, such as tablets, wherein a binder liquid is deposited dropwise on a layer of powder, with these steps being repeated, in one or more patterns, in order to generate a solid drug product. In accordance with the invention, the powder comprises lactose particles having a particle size distribution characterized by a D10 of at least 6 μm.
Owner:DFE PHARMA GMBH & CO KG

Cough-relieving tablets and preparation method thereof

The invention discloses cough-relieving tablets which are prepared by carrying out dry granulation and tablet pressing on medicinal material extract paste powder, lactose powder, microcrystalline cellulose, pregelatinized starch, silicon dioxide, magnesium stearate and polyethylene glycol 4000. The invention further discloses a preparation method of the cough-relieving tablets, which comprises the following steps: firstly uniformly mixing the lactose powder, the pregelatinized starch and the medicinal material extract paste powder, and being uniformly mixed with the microcrystalline cellulose and the polyethylene glycol 4000; and carrying out the dry granulation on the mixed materials, preparing granules, then carrying out final mixing with the magnesium stearate and the silicon dioxide, and carrying out the tablet pressing for preparing the cough-relieving tablets. The tablets prepared by adopting the dry granulation and the tablet pressing can effectively improve the hardness and the stability of the tablets, solve the problems of unqualified disintegration time limit and unqualified microorganisms, further improve the product quality, lead the process flow to be simple, save energy, save cost and be suitable for industrial production.
Owner:HAINAN HULUWA PHARMA GRP CO LTD

Blueberry fruit-vinegar drink beneficial to improving intestinal environment of human body and promoting health and preparation method thereof

The invention discloses blueberry fruit-vinegar drink beneficial to improving intestinal environment of human body and promoting health. The blueberry fruit-vinegar drink is prepared from the following components in parts by weight: 145-150 parts of fresh and undamaged blueberry fruits, 140-145 parts of fresh and undamaged Chinese yew fruits, 5-6 parts of stachyose, 11-12 parts of selenium-enriched yeast, 14-15 parts of acetic acid bacteria, 9-10 parts of eater producing yeast, 4-5 parts of fungus polyphenol, 6-7 parts of isomerized lactose powder, 7-8 parts of seaweed enzyme, 5-6 parts of inulin, 5-6 parts of L-arabinose and 5-6 parts of polydextrose. The blueberry fruit-vinegar drink has the advantages that the Chinese yew fruits full of nutrients are adopted and combined with concentrated compound fruit juice of the blueberry fruits, pomace fermented products and nutrient enrichment substances for preparing compound fruit-vinegar drink, the prepared compound fruit-vinegar drink is rich in nutrient substances such as amino acids and vitamins and has relatively high nutritional value, and by combining the nutrient enrichment substances, rapid proliferation of effective microbial florae in intestinal tract can be promoted and peristalsis of intestines can be sped up, so that toxic metabolic substances in the intestines are quickly excreted, and the effects of improving the intestinal environment of the human body and promoting health are realized.
Owner:HUAINING DABIE MOUNTAINS TEA & WINE

Breadcrumbs with crispy taste and preparation method thereof

The invention discloses breadcrumbs for fried food. The breadcrumbs are prepared from the following components in parts by mass: 25-35 parts of flour, 10-15 parts of corn flour, 5-10 parts of wheat germ flour, 3-5 parts of walnut powder, 15-35 parts of water, 5-10 parts of oil, 3-5 parts of unsalted butter, 1-3 parts of condensed milk, 15-20 parts of powdered sugar and 1-3 parts of egg liquid. According to the breadcrumbs, the formula of common breadcrumbs is improved, the feeding speed is increased, the extrusion temperature is increased, the time required for extrusion and puffing of the paste is reduced, the excessive puffing proportion of the paste is greatly reduced, the bitter taste is reduced, and the crispy taste is improved at the same time.
Owner:滁州润泰清真食品有限公司

A preparation method of Saccharomyces cerevisiae and isomerized lactose powder

The invention discloses a preparation method of Saccharomyces cerevisiae and isomerized lactose powder, which comprises the following steps: adding Saccharomyces cerevisiae LJSM‑01 to a lactose isomerization solution, carrying out fermentation, and removing galactose in the solution; removing galactose The fermented lactose liquid is subjected to sterilizing, decolorizing, ion exchange and evaporative concentration, followed by simulated moving bed chromatographic purification, and the obtained isomerized lactose solution is concentrated and crystallized to obtain isomerized lactose powder. The Saccharomyces cerevisiae can ferment all the galactose in it without fermenting the isomerized lactose. It adopts the two-step purification method of fermentation method and simulated moving bed chromatography separation method, and the obtained isomerized lactose liquid has high purity, The advantage of high yield meets the requirements of industrial production.
Owner:山东绿健生命生物科技有限公司

Preparation method of glaangal and ganoderma lucidum health care beverage

InactiveCN104256845AHigh extraction rateHarmonize bitternessTea substituesMedicineMaltodextrin
The invention discloses a preparation method of glaangal and ganoderma lucidum health care beverage. The method comprises the following steps: firstly, preparing bitter caramon and ganoderma lucidum particles, secondly, preparing bitter caramon extract liquor, thirdly, preparing ganoderma lucidum extract liquor, fourthly, respectively obtaining bitter caramon embedding powder and ganoderma lucidum embedding powder, fifthly, uniformly mixing the bitter caramon embedding powder and ganoderma lucidum embedding powder obtaining in the fourth step with boxthorn powder, hawthorn fruit powder, lactose powder and maltodextrin, and sixthly, performing drying, pelletization and sieving, so as to obtain glaangal and ganoderma lucidum tea. The preparation method not only provides convenient glaangal and ganoderma lucidum healthy solid beverage for people, but also opens a new approach for the comprehensive utilization of valuable ganoderma lucidum resource, and provides a product with high market competitiveness for the health of the public.
Owner:海南壹号药业有限公司

Milk tea tablet and production process thereof

The invention discloses a milk tea tablet. The milk tea tablet is prepared from raw material in parts by weight: 10-14 parts of whole milk powder, 0.4-1.5 parts of black tea powder, 3-8 parts of sucrose powder, 3-15 parts of lactose powder, 0.2-0.5 part of sodium carboxymethyl cellulose, 0.0001-0.03 part of ethyl maltol, and 1-4 parts of corn starch. The invention also discloses a process for producing the milk tea tablet. The instant milk tea tablet has rich milk tea flavor, mellow mouth feeling, and moderate saccharinity; and the milk tea tablet prepared by the prescription is difficult to disintegrate, has stable structure, can be directly eaten or brewed to drink, and is an ideal leisure food. Meanwhile, the consumer can add coffee powder or chocolate powder and the like into the milktea according to personal taste to form corresponding flavor milk tea.
Owner:ZHEJIANG UNIV

Manidipine hydrochloride tablet for treating hypertension and preparation method thereof

theThe invention discloses a Manidipine dihydrochloride tablet for treating hypertension and a preparation method thereof. The tablet contains Manidipine dihydrochloride, sodium dodecanesulphonate, polyethylene glycol 6000, lactose and magnesium stearate. The preparation method comprises the following steps: (1) fusion of polyethylene glycol 6000 is carried out; (2) Manidipine dihydrochloride, sodium dodecanesulphonate and lactose are crushed, and then the materials and fused polyethylene glycol 6000 mixed by a powder injection apparatus; (3) the materials mixed in the step (2) are heated to 120-150 DEG C, stirring is carried out at a rotating speed of 220-280 r / min for 1-2 minutes, cooling is carried out for 75-85 DEG C, magnesium stearate is added and stirring is carried out for 30 minutes, materials are transferred to a drying box, drying is carried out, and materials are dried and pressed into tablets in order to obtain the Manidipine dihydrochloride tablet. The invention providesthe Manidipine dihydrochloride tablet for treating hypertension, the tablet has higher dissolution rate, the dissolution rate of the tablet reaches 98.2% or above, the preparation method is stable andreliable, and the method is suitable for industrialized production.
Owner:佛山德芮可制药有限公司

Lactose powder bed three dimensional printing

Disclosed is the 3D printing of pharmaceutical formulations, such as tablets, wherein a binder liquid is deposited dropwise on a layer of powder, with these steps being repeated, in one or more patterns, in order to generate a solid drug product. In accordance with the invention, the powder comprises lactose particles having a particle size distribution characterized by a D10 of at least 6 micrometers.
Owner:DFE PHARMA GMBH & CO KG
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