Sulfadimidine microcapsules and preparation method thereof

A technology of sulfamethazine and microcapsules, which is applied in the field of sulfamethazine microcapsules and their preparation, can solve the problems of reduced yield, low efficiency, uncontrollable coagulation effect of single coacervation method, etc., and achieves the effect of shortening reaction time

Inactive Publication Date: 2018-03-06
铜陵市宏达家电有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The coagulation effect of the single coacervation method is uncontrollable, and satisfactory microcapsules need to be made after many repetitions, which has low efficiency and high cost; the complex coacervation method has higher requirements for operation, and the solution must be stirred evenly when adjusting the pH value. And to reach a specific pH range, always stir during the preparation of microcapsules, and stirring will produce foam and reduce the yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: sulfamethazine microcapsules, it comprises by weight: 10 parts of sulfamethazine, 6 parts of rosin, 8 parts of crystalline lactose powder, 4 parts of dextran, 6 parts of disodium stannous citrate and 20 parts deionized water.

[0012] The preparation method of sulfamethazine microcapsules comprises the following steps: placing 8 parts of crystalline lactose powder in 20-30 parts of deionized water, stirring evenly, heating to 40°C, concentrating and distilling to make 1 / 4 of the original volume For soft material, grind 6 parts of rosin into fine powder and pass through a 100-mesh sieve, then add it to the soft material and stir evenly, and keep it warm at 20°C for 20 minutes; min; add 4 parts of dextran and heat to 60°C for 10 minutes; add 6 parts of disodium stannous citrate and cool to 10°C within 3 minutes.

Embodiment 2

[0013] Embodiment 2: sulfamethazine microcapsules, it comprises by weight: 15 parts of sulfamethazine, 8 parts of rosin, 9 parts of crystalline lactose powder, 6 parts of dextran, 8 parts of disodium stannous citrate and 25 parts deionized water.

[0014] The preparation method of sulfamethazine microcapsules comprises the following steps: putting 9 parts of crystalline lactose powder in 25 parts of deionized water, stirring evenly, heating to 45°C, concentrating and distilling to make a soft material with 1 / 5 of the original volume , Grind 8 parts of rosin into fine powder, pass through a 100-mesh sieve, add to soft material and stir evenly, keep warm at 25°C for 25 minutes; add 15 parts of sulfamethazine, put it into the reactor and stir evenly, the stirring speed is 55r / min; Add 6 parts of dextran and heat to 65°C for 15 minutes; add 8 parts of disodium stannous citrate and cool to 12°C within 5 minutes.

Embodiment 3

[0015] Embodiment 3: sulfamethazine microcapsules, it comprises by weight: 20 parts of sulfamethazine, 12 parts of rosin, 10 parts of crystalline lactose powder, 8 parts of dextran, 10 parts of disodium stannous citrate and 30 parts deionized water.

[0016] The preparation method of sulfamethazine microcapsules comprises the following steps: putting 10 parts of crystalline lactose powder in 30 parts of deionized water, stirring evenly, heating to 50°C, concentrating and distilling to make a soft material with 1 / 6 of the original volume , Grind 12 parts of rosin into fine powder, pass through a 100-mesh sieve, add to soft material and stir evenly, keep warm at 30°C for 30 minutes; add 20 parts of sulfamethazine, put it into the reactor and stir evenly, the stirring speed is 60r / min; Add 8 parts of dextran and heat to 70°C for 20 minutes; add 10 parts of disodium stannous citrate and cool to 14°C within 7 minutes.

[0017] The present invention utilizes the high drug holding c...

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Abstract

The invention discloses sulfadimidine microcapsules which comprise the following components in parts by weight: 10-20 parts of sulfadimidine, 6-12 parts of rosin, 8-10 parts of crystalline lactose powder, 4-8 parts of glucosan, 6-10 parts of disodium stannous citrate and 20-30 parts of deionized water. The sulfadimidine microcapsules disclosed by the invention have the beneficial effects that theadded crystalline lactose powder is capable of promoting preforming of a capsule wall material, the prepared sulfadimidine microcapsule has the specified shape, repeated agglomeration is not needed, the rosin and disodium stannous citrate are capable of accelerating agglomeration and solidification of the microcapsules, the reaction time is shortened, and stable microcapsules are formed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to sulfamethazine microcapsules and a preparation method thereof. Background technique [0002] Microcapsules (referred to as microcapsules) use polymer materials (commonly known as capsule materials) to wrap solid or liquid drugs (commonly known as capsule cores) into microcapsules with a diameter of 0.01-200 μm. After the drug is microencapsulated, it has a slow-release effect, which can improve the stability of the drug, mask the bad smell and taste of the drug, reduce the irritation of the drug to the gastrointestinal tract, reduce the incompatibility of compound drugs, and improve the fluidity and availability of the drug. Compressibility, so that liquid drugs can be solidified. There are many preparation methods of microcapsules, which can be classified into three categories: physical chemical method, chemical method and physical mechanical method. It can be select...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/635A61K47/26A61K47/46A61K47/12
Inventor 何朝德
Owner 铜陵市宏达家电有限责任公司
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