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Cod-liver oil micro capsule and preparation method thereof

A technology of cod liver oil and microcapsules, which is applied in the direction of microcapsules, capsule transportation, and medical raw materials derived from fish feed, etc., can solve the problems of reduced yield, uncontrollable coagulation effect of single coacervation method, high cost, etc., and achieve the effect of shortening the reaction time

Inactive Publication Date: 2018-04-06
安徽金阳光农业服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The coagulation effect of the single coacervation method is uncontrollable, and satisfactory microcapsules need to be made after many repetitions, which has low efficiency and high cost; the complex coacervation method has higher requirements for operation, and the solution must be stirred evenly when adjusting the pH value. And to reach a specific pH range, always stir during the preparation of microcapsules, and stirring will produce foam and reduce the yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: cod liver oil microcapsules, it comprises by weight: 10 parts of cod liver oil, 6 parts of turpentine, 8 parts of microcrystalline cellulose, 4 parts of gum arabic, 6 parts of potassium aluminum sulfate dodecahydrate and 20 parts of deionized water.

[0012] The preparation method of cod liver oil microcapsules comprises the following steps: placing 8 parts of microcrystalline cellulose in 20 parts of deionized water, stirring evenly, heating to 40°C, concentrating and distilling to make a soft material of 1 / 4 of the original volume, and Heat 6 parts of turpentine oil to 60°C, add it to soft material and stir evenly, keep it warm at 20°C for 20 minutes; add 10 parts of cod liver oil, put it into the reaction kettle and stir evenly, the stirring speed is 50r / min; add 4 parts of gum arabic, and heat to 60 Keep warm at ℃ for 10 minutes; add 6 parts of potassium aluminum sulfate dodecahydrate and cool to 10℃ within 3 minutes.

Embodiment 2

[0013] Embodiment 2: cod liver oil microcapsules, it comprises by weight: 15 parts of cod liver oil, 8 parts of turpentine, 9 parts of microcrystalline cellulose, 6 parts of gum arabic, 8 parts of potassium aluminum sulfate dodecahydrate and 25 parts of deionized water.

[0014] The preparation method of cod-liver oil microcapsules comprises the following steps: placing 9 parts of microcrystalline cellulose in 25 parts of deionized water, stirring evenly, heating to 45° C., concentrating and distilling to make a soft material of 1 / 5 of the original volume, and Heat 8 parts of turpentine oil to 65°C, add to soft material and stir evenly, keep warm at 25°C for 25 minutes; add 15 parts of cod liver oil, put it into the reaction kettle and stir evenly, the stirring speed is 55r / min; add 6 parts of gum arabic, and heat to 65 Keep warm at ℃ for 15 minutes; add 8 parts of potassium aluminum sulfate dodecahydrate and cool to 12℃ within 5 minutes.

Embodiment 3

[0015] Embodiment 3: Cod liver oil microcapsules, which include by weight: 20 parts of cod liver oil, 12 parts of turpentine, 10 parts of microcrystalline cellulose, 8 parts of gum arabic, 10 parts of potassium aluminum sulfate dodecahydrate and 30 parts of deionized water.

[0016] The preparation method of cod liver oil microcapsules comprises the following steps: placing 10 parts of microcrystalline cellulose in 30 parts of deionized water, stirring evenly, heating to 50° C., concentrating and distilling to make a soft material of 1 / 6 of the original volume, and Heat 12 parts of turpentine oil to 70°C, add it to soft material and stir evenly, keep it warm at 30°C for 30 minutes; add 20 parts of cod liver oil, put it into the reaction kettle and stir evenly, the stirring speed is 60r / min; add 8 parts of gum arabic, and heat to 70 Insulate at ℃ for 20 minutes; add 10 parts of potassium aluminum sulfate dodecahydrate and cool to 14 ℃ within 7 minutes.

[0017] The present inve...

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PUM

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Abstract

The invention discloses a cod-liver oil micro capsule. The cod-liver oil micro capsule is prepared from, by weight, 10-20 parts of cod-liver oil, 6-12 parts of turpentine oil, 8-10 parts of microcrystalline cellulose, 4-8 parts of Arabic gum, 6-10 parts of aluminum potassium sulfate dodecahydrate and 20-30 parts of deionized water. The cod-liver oil micro capsule has the advantages that preformingof a capsule wall material can be facilitated by adding the microcrystalline cellulose, the obtained cod-liver oil micro capsule is specific in shape, multi-time repetitive condensation is not needed, the condensation and the solidification of the micro capsule can be accelerated due to the turpentine oil and the aluminum potassium sulfate dodecahydrate, the reaction time is shortened, and the stable micro capsule is formed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to cod liver oil microcapsules and a preparation method thereof. Background technique [0002] Microcapsules (referred to as microcapsules) use polymer materials (commonly known as capsule materials) to wrap solid or liquid drugs (commonly known as capsule cores) into microcapsules with a diameter of 0.01-200 μm. After the drug is microencapsulated, it has a slow-release effect, which can improve the stability of the drug, mask the bad smell and taste of the drug, reduce the irritation of the drug to the gastrointestinal tract, reduce the incompatibility of compound drugs, and improve the fluidity and availability of the drug. Compressibility, so that liquid drugs can be solidified. There are many preparation methods of microcapsules, which can be classified into three categories: physical chemical method, chemical method and physical mechanical method. It can be selecte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61K9/50A61K47/38A61K47/20A61K47/44
CPCA61K35/60A61K9/5015A61K9/5047
Inventor 陆必红
Owner 安徽金阳光农业服务有限公司
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