43 results about "Isoamoenylin" patented technology

The invention belongs to the technical field of medicaments, and in particular relates to application of isopentene group flavonoid compound used as a pancreatic lipase inhibitor. The flavonoid compound has the following structural formula and has a chemical name of: (E)-2-(2,4-dihydroxy phenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-6-(3-methy-l-butenyl)-4H-chromene-4-ketone, and can be extracted from artocarpus nitidus. Pancreatic lipase activity tests and experiments of weight loss action in animals prove that the compound has obvious pancreatic lipase inhibitory activity and weight loss action, can be taken as the lead compound for developing novel medicaments for preventing or curing obesity and related metabolic diseases, and also can be used for preparing the medicaments for preventing and curing clinically common multiple obesity and the related metabolic disease.

The invention discloses novel medical application of isopentenyl isoflavone compounds in licorice roots. Through systematic research on the chemical components and activity screening of the licorice roots, it is discovered that the isopentenyl isoflavone compounds including licoricidin, angustone A and glyasperin D of which the structures are similar have the significant activity on inhibition of cancer cell proliferation and inhibition of protein tyrosine phosphatase 1B (PTP1B), licoricidin and glyasperin D have the significant activity on inhibition of acetylcholine esterase (AChE), and glyasperin D also has the significant activity on inhibition of tyrosinase. On the basis of the discovery, the active compounds or salt, ester and solvent compounds, stereoisomers, tautomer and prodrugs which are acceptable in pharmacy of the active compounds and mixtures of the compounds can be used for preparing anti-cancer drugs, PTP1B inhibitors, antidiabetic drugs, tyrosinase inhibitors, freckle removing and whitening products, AChE inhibitors, anticholinesterase drugs and the like.

The invention relates to an extract of an epimedium plant, i.e., isopentenyl flavonoid with antineoplastic activity and as shown in a formula (I) which is described in the specification, a preparationmethod thereof, a pharmaceutical composition with the isopentenyl flavonoid as shown in the formula (I) as an active component and for treating and preventing tumors, and application of the isopentenyl flavonoid and the pharmaceutical composition to preparation of drugs used for treating and preventing tumors.

The invention relates to a substituted 2,2-dimethylthiazolidin compound, as well as a preparation method and use thereof, and particularly discloses a compound with a general formula (I), pharmaceutically acceptable salts of the compound, a medicinal composition comprising the compound and the use of the compound in radiation protection and protection of the hematopoietic and immune system. In the general formula (I), R is selected from C1 to C6 linear and branched unsaturated alkyl substituents, preferably an allyl group, an isopentene group and 2-butenyl, can also be an aromatic base and a substituted aromatic group, preferably a benzyl group and a substituted benzyl group, and can further be a C1 to C6 linear and branched carbonyl substituent, wherein the carbonyl substituent can also be substituted by a heteroaromatic ring-containing substituent and sulphydryl-containing amino acid.

The invention relates to isopentenylated flavonoid compound sinoflavonoids as well as a preparation method and application thereof. The method can be used for effectively solving the problem of extracting the isopentenylated flavonoid compound sinoflavonoids from fructus podophylli, and preparing of the products into anti-prostate cancer drugs. The isopentenylated flavonoid compound sinoflavonoidscomprise Sinoflavanonoid NF I, Sinoflavanonoid NG II, Sinoflavanonoid NH III, Sinoflavanonoid NI IV which are extracted from fructus podophylli. The novel isopentenylated flavonoid compound sinoflavonoids NF-NI have cytotoxic activity on human prostate cancer cell strain PC-3, have the prospect of being prepared into anti-prostatic cancer medicine; the repeatability of the preparation method is high; the purity of obtained compounds is high; it in favor of further pharmacological and clinical research of the compounds, and the medicinal value of the fructus podophylli medicine and a new way for preparing the anti-prostatic cancer medicine are developed.

The invention relates to an isopentene flavonol glycoside derivative with a structure shown as a general formula (I) and a preparation method and application thereof. In the isopentene flavonol glycoside derivative, R1 refers to rhamnosyl, R2, R3, R4 and R7 refer to H, R5 refers to methoxyl, and R6 refers to hydroxyl; or R1, R4, R6 and R7 refer to H, R2 refers to xylosyl, R3 refers to acetyl, and R5 refers to hydroxyl; or R1, R3, R6 and R7 refer to H, R2 refers to xylosyl, R4 refers to glucosyl, and R5 refers to hydroxyl; or R1 refers to rhamnosyl, R2, R3 and R6 refer to H, R4 refers to glucosyl, R5 refers to methoxyl, and R7 refers to hydroxyl. The invention further relates to application of the isopentene flavonol glycoside derivative to the prevention and treatment of osteoporosis.

The invention discloses preparation of isopentenyl flavone and application of isopentenyl flavone as a drug for treating cervical cancer, and relates to the technical field of drugs. The isopentenyl flavone is obtained by adopting dry rhizomes of ficus microcarpa plant radix fici simplicissimae through the steps of crushing, solvent extraction, macroporous adsorption resin column chromatography, silica gel column chromatography, ODS column chromatography, liquid phase preparation and the like. Pharmacological activity shows that the isopentenyl flavone compound can obviously inhibit proliferation of human cervical cancer cell strains, influence AKT / MAPK signal channels and promote apoptosis of cervical cancer cells, and the isopentenyl flavone compound has an anti-cervical cancer effect, can be used as a candidate drug for development of anti-cervical cancer drugs and has important significance in development of the anti-cervical cancer drugs.

The invention relates to an isopentenyl flavonoid compound extracted from cyclocarya paliurus, and particularly discloses an extraction method and application of the isopentenyl flavonoid compound; a structure of the isopentenyl flavonoid compound of the cyclocarya paliurus is as shown in formula I; the isopentenyl flavonoid compounds 1-27 of the cyclocarya paliurus and an n-butyl alcohol active site of the cyclocarya paliurus achieve a relatively good effect in an activity test for preparing a drug for improving gout and reducing uric acid, and are expected to become a new generation of drugs for improving gout and reducing uric acid.

The invention provides a method for fully synthesizing and preparing dehydrated icariin. In the present invention, by using trihydroxyacetophenone, p-methoxybenzoyl chloride, prenyl bromide, etc. as raw materials, the prenyl group is first connected to the 8-position carbon through the rearrangement of the ortho position, and then the flavone skeleton is formed. A series of reactions are formed to obtain dehydrated icariin. The invention improves the disadvantages of low yield, expensive catalyst and many by-products of introducing isopentenyl groups in the traditional method, and has low cost, simple operation and good yield, and is suitable for industrialized production.

The invention discloses truncated sophora flavescens isopentenyl transferase and application thereof, and belongs to the field of bioengineering. On the basis of isopentenyl transferase SfN8DT-1 from sophora flavescens, truncation of different sites is respectively carried out on an N terminal, and a recombinant plasmid pY26-SfN8DT-1 and seven truncated isopentenyl transferase mutant plasmids are constructed. The recombinant plasmid is transferred into saccharomyces cerevisiae to obtain a recombinant saccharomyces cerevisiae strain for denovo synthesis of 8-isopentenyl naringenin. The recombinant saccharomyces cerevisiae can produce 9.33 mg / L of the 8-isopentenyl naringenin at most after being fermented in a YPD culture medium for 120 hours, the yield is improved by 290.10% compared with that of a control strain PN01-pY26-SfN8DT-1, and the yield of the 8-isopentenyl naringenin is the highest among currently reported yields of biosynthesized 8-isopentenyl naringenin. The strategy lays a foundation for producing the 8-isopentenyl naringenin by transforming the saccharomyces cerevisiae through metabolic engineering.

The invention relates to the technical field of medical microbial chemistry. The invention relates to the technical field of biological medicines, and particularly discloses medical application of oneor four isopentenyl substituted phenol compounds separated from a fermentation product of Sclerotium hirsutum in preparation of antibacterial medicines. The invention particularly relates to an application in preparing medicines for inhibiting the growth of staphylococcus aureus and methicillin-resistant staphylococcus aureus. An antibacterial activity test proves that the isopentenyl substitutedphenol compound and the derivative of the isopentenyl substituted phenol compound can be used for remarkably inhibiting staphylococcus aureus and methicillin-resistant staphylococcus aureus (MRSA) and its use as a novel agricultural or medical antibacterial and drug-resistant bacterial drug.

The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R′ is selected from a group consisting of t-butyl amine, n-butylamine, iso-butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)-piperazin-1-ylamine, and 3,4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of Oil, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

The invention relates to a method for introducing isopentenyl at the C3 position of indole. Specifically, using indole and isoprene as raw materials, under the promotion of a palladium catalyst / phosphine ligand, an isopentenyl group can be introduced at the C3 position of indole with high selectivity. The present invention has the following advantages: isoprene is a green bulk chemical, simple and easy to obtain, and cheap; simple indole can participate in the reaction without the need to protect NH; no leaving group, atom High economy.

The invention discloses a novel isopentenyl flavonoid compound, which is prepared by adopting the following steps: (1) taking Epimedium medicinal materials, pulverizing or not pulverizing, and extracting 1-3 times with a solvent, extracting 0.2-3 times each time After 3 hours, the two extracts were combined and concentrated under reduced pressure to obtain an extract; (2) water was added to the extract to obtain a suspension, the suspension was separated by gradient elution of macroporous resin, and then passed through an ODS column Gradient elution separation was performed, and finally the prenyl flavonoids were purified by high performance preparative liquid phase. The isopentenyl flavonoids can be converted into icariin under the conditions of heating, acid treatment, enzyme treatment, alkali treatment and the like. The invention is easy to operate, and the prepared compound has high purity.

The invention provides an application of a quinone chalcone compound in the preparation of antitumor drugs, the quinone chalcone compound is a quinone chalcone compound with a prenyl group in the A ring, and also provides such compounds in In the treatment of tumor diseases as a single drug or combined drug application, the quinoidal chalcone itself has a strong anti-tumor ability. When used in combination with anti-tumor drugs such as interferon, it can not only kill differentiated tumor cells, but also Killing the dormant tumor stem cells has the effect of completely eliminating tumor cells.

The invention discloses a quinoid chalcone compound with an isopentenyl group at an A ring, and a preparation method and anti-inflammatory activity thereof. The compound has a structure as shown in a general formula (I) which is described in the specification. The preparation method comprises the following steps: (1) synthesizing 3,5-dihydroxy-2-acetyl-6,6-diisopentenylcyclohexyl-2,4-dienone; (2) synthesizing 3-hydroxy-5-methoxy-2-acetyl-6,6-diisopentenylcyclohexyl-2,4-dienone; (3) synthesizing a methoxy group protected quinoid chalcone compound with the isopentenyl group at the A ring; and (4) synthesizing the quinoid chalcone compound with the isopentenyl group at the A ring. The compound is simple to prepare and has obvious anti-inflammatory action.

The invention relates to a method for extracting 5-isopentenyl aureusidin from eleocharis tuberose peels and belongs to the field of natural organic chemistry. The method is characterized by comprising the following steps of as an aqueous solution of acetone is used as a solvent, extracting the 5-isopentenyl aureusidin from the eleocharis tuberose peels to obtain an extract, extracting the extract with ethyl acetate to obtain an extractant, separating the extractant with a medium-pressure MCI column chromatography and a polyamide column chromatography to obtain a matter and repeatedly purifying the matter with a Sephadex LH-20 gel chromatography to obtain a 5-isopentenyl aureusidin product of which the content of the 5-isopentenyl aureusidin is above 95%. According to the method, a novel way for extracting and separating the 5-isopentenyl aureusidin from natural plants is created, the good separation effect is achieved, the product is high in purity, the eleocharis tuberose peels always regarded as wastes are changed into treasure, chromatographic materials, namely, MCI, polyamide and sol, can be repeatedly used, and the method has the advantages that raw materials are easily available, resources are abundant and the production cost is low; the product can be subjected to large-scale production and meets the needs of pharmaceutical industry.

The invention relates to isopentenyl stilbene and application thereof to preparation of drugs for treating inflammatory diseases. The isopentenyl stilbene is a new compound separated from artocarpus styracifolius Pierre which is a moraceae artocarpus plant, is named (+ / -)-artocarpus styracifolius phenol D, and has a structure as shown in the following description. The compound has strong inhibitory activity on rat polymorphonuclear neutrophils (PMNs) respiratory burst, the IC50 is 1.5+ / -0.22 muM, and the compound can be further used for preparing the drugs for treating the inflammatory diseases, and is used in clinical treatment of various oxidative damage, such as rheumatoid arthritis, compensatory anti-inflammatory response syndrome (CARS), and systemic inflammatory response syndrome (SIRS), caused by the excessive activation of PMNs.

The invention discloses a (trans)-beta-farnesene analogue containing hydroxypiperidine as well as preparation and an application thereof. The structural formula of the (trans)-beta-farnesene analoguecontaining hydroxypiperidine is shown as a formula I, a formula II, a formula III or a formula IV, wherein in the formula, R1 is one of hydrogen, C1-C10 alkanoyl, benzoyl, (E)-3, 7-dimethyl-2, 6-octadiene acyl and isopentenyl; R2 is hydrogen or an isopentenyl group; and R3 is hydrogen or isopentenyl. The (trans)-beta-farnesene analogue containing hydroxypiperidine disclosed by the invention can be applied to prevention and control of agricultural pests, particularly prevention and control of aphids.

The invention discloses an FAD-dependent oxidase Ma-1 in an anabolic pathway of a Diels-Alder type adduct and an application of the FAD-dependent oxidase Ma-1. The invention provides the following proteins: an Ma-1 protein as shown in SEQ ID No. 3 and / or an Ma-2 protein as shown in SEQ ID No. 4. Ma-1 and Ma-2 have FAD-dependent oxidase characteristic structural domains, the Ma-1 can catalyze isopentenyl side chains of isopentenyl phenolic compounds to be dehydrogenated and rearranged to form dienes, and catalyze the isopentenyl side chains of the isopentenyl phenolic compounds to react with isopentenyl ortho-hydroxyl to form a ring after being dehydrogenated; and the Ma-2 can catalyze [4+2] cyclization reaction between the diene and double bonds of chalcone compounds to form a Diels-Aldertype adduct. The FAD-dependent oxidase Ma-1 disclosed by the invention has important theoretical and practical significance for producing the Diels-Alder type adduct and researching an enzymatic Diels-Alder type [4+2] cyclization reaction mechanism.

The invention relates to a method for introducing a tertiary isopentenyl group at the C3 position of indole. Specifically, using indole and isoprene as raw materials, under the promotion of rhodium catalyst / phosphine ligand, a tertiary isopentenyl group can be introduced at the C3 position of indole with high selectivity. The present invention has the following advantages: isoprene is a green bulk chemical, simple and easy to obtain, and cheap; simple indole can participate in the reaction without the need to protect NH; no leaving group, atom High economy.

The invention relates to the technical field of medicinal microbial chemistry, and specifically discloses a strain of Bacillus chamois ( Stereum hirsutum ) isolated from the fermentation product of four isopentenyl substituted phenolic compounds for the preparation of antimicrobial drugs, specifically in the preparation of anti-Staphylococcus aureus and methicillin-resistant grape aureus Drug application for cocci growth. The antibacterial activity test of the present invention confirms that isopentenyl substituted phenolic compounds and derivatives thereof of the present invention can significantly inhibit Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (methicillin-resistant Staphylococcus aureus , MRSA), and has the application of preparing new agricultural or medical antibacterial and drug-resistant bacterial drugs.

The invention belongs to the technical field of medicine, and relates to a prenylflavonoid compound with a structure of formula (I) and its application. Specifically related to said compound 8-(3,4-dihydroxybenzene)-5-hydroxy-7-methoxy-2-hydroxymethyl-2-methyl-10-(3-methyl-2-butene Base)-2H, 6H-benzo[1,2-b:5,4-b']dipyran-6-one and its use in the preparation of protein tyrosine phosphatase 1B inhibitors. The compound is extracted from rattan. Experiments have confirmed that the compound has a strong inhibitory activity on protein tyrosine phosphatase 1B, and can be used as a protein tyrosine phosphatase 1B inhibitor and to develop new drugs for preventing or treating type 2 diabetes The lead compound of the invention can also be used for the preparation of drugs for preventing or treating type 2 diabetes which is commonly seen in clinical practice.

The invention provides a preparation method of 3-methyl-2-butene-1-aldehyde diisopentenyl acetal and a preparation method of the 3-methyl-2-butene-1-aldehyde diisopentenyl acetal. According to the method, the isopentenol in which the content of 2, 4, 4-trimethyl-3-formyl-1, 5-hexadiene is controlled to be 0.001-0.05 wt% is used as a raw material, so that side reactions in the condensation reaction process can be effectively reduced, the selectivity of the 3-methyl-2-butene-1-aldehyde diisopentenyl acetal is improved by more than or equal to 5% in terms of the isopentenol, and the economic benefit is remarkably increased.

The invention relates to the field of natural medicines, and discloses an isopentenyl-substituted coumarin compound which is derived from artocarpus heterophyllus and has a novel chemical structure, a preparation method of the isopentenyl-substituted coumarin compound and application of the isopentenyl-substituted coumarin compound in anti-tumor medicines, and various in-vitro anti-tumor activity evaluation results of the compound artoheterronin show that the compound has remarkable anti-tumor activity, has the protein tyrosine kinase inhibition activity equivalent to that of a positive control drug, can be further developed into an anti-tumor drug taking protein tyrosine kinase as a target, can be applied to the anti-tumor drug, is simple in separation and purification process and mild in reaction condition, and has practical significance.

The invention relates to a natural medicine, and in particular relates to a novel isoflavanone isoflavanone compound in wild peanuts as well as a preparation method and application of the compound. The novel isoflavanone isoflavanone compound provided by the invention has a structural formula shown in a formula (I). The preparation method comprises the following steps of: a, crushing; b, refluxing and extracting; c, concentrating; d, extracting; and e, separating. The novel isoflavanone isoflavanone compound shown in the formula (I) has a remarkable inhibition function to a human cervical carcinoma, human chronic myeloid leukemia or human acute myelogenous leukemia cell strain, has a better anti-cancer activity, and can be used as an anti-cancer active component or lead compound. The novel isoflavanone isoflavanone compound can be a natural organic compound, is wide in raw material source, is simple in preparation process, is high in purity, is easily realized in subsequent industrialized production, is used for preparing a medicament for preventing or treating tumors, and is used for clinically treating human cervical carcinoma, human chronic myeloid leukemia or human acute myelogenous leukemia.

The invention discloses a field sampling treatment agent for date palm, comprising reagent A and reagent B, wherein the reagent A includes 1000-1500 times dilution of azoxystrobin, 1000-1500 times dilution of difenoconazole and carbendazim 800-1000-fold dilution, reagent B includes 6-benzylaminoadenine solution with mass concentration of 5-15mg / L and isopentenyl adenine solution with mass concentration of 1-5mg / L; preparation method: (1) Weigh azoxystrobin, difenoconazole and carbendazim, then dilute with water respectively, and mix to obtain reagent A; (2) weigh 6-benzylaminoadenine and isopentenyladenine, then use respectively Dissolve the sodium hydroxide solution, dilute to volume with sterile water, and mix to obtain reagent B. The field sampling treatment agent for the date palm of the invention can significantly reduce the fungal contamination rate and the endophyte contamination rate, so that the explants can maintain high differentiation ability, and it is easier to carry out detoxification treatment in the process of tissue culture, improve cell differentiation ability, and promote explants. Implants induce callus and shorten the induction period.