43 results about "Isoamoenylin" patented technology

The invention provides a method for fully synthesizing and preparing dehydrated icariin. In the present invention, by using trihydroxyacetophenone, p-methoxybenzoyl chloride, prenyl bromide, etc. as raw materials, the prenyl group is first connected to the 8-position carbon through the rearrangement of the ortho position, and then the flavone skeleton is formed. A series of reactions are formed to obtain dehydrated icariin. The invention improves the disadvantages of low yield, expensive catalyst and many by-products of introducing isopentenyl groups in the traditional method, and has low cost, simple operation and good yield, and is suitable for industrialized production.

The invention provides an application of a quinone chalcone compound in the preparation of antitumor drugs, the quinone chalcone compound is a quinone chalcone compound with a prenyl group in the A ring, and also provides such compounds in In the treatment of tumor diseases as a single drug or combined drug application, the quinoidal chalcone itself has a strong anti-tumor ability. When used in combination with anti-tumor drugs such as interferon, it can not only kill differentiated tumor cells, but also Killing the dormant tumor stem cells has the effect of completely eliminating tumor cells.

The invention relates to a method for extracting 5-isopentenyl aureusidin from eleocharis tuberose peels and belongs to the field of natural organic chemistry. The method is characterized by comprising the following steps of as an aqueous solution of acetone is used as a solvent, extracting the 5-isopentenyl aureusidin from the eleocharis tuberose peels to obtain an extract, extracting the extract with ethyl acetate to obtain an extractant, separating the extractant with a medium-pressure MCI column chromatography and a polyamide column chromatography to obtain a matter and repeatedly purifying the matter with a Sephadex LH-20 gel chromatography to obtain a 5-isopentenyl aureusidin product of which the content of the 5-isopentenyl aureusidin is above 95%. According to the method, a novel way for extracting and separating the 5-isopentenyl aureusidin from natural plants is created, the good separation effect is achieved, the product is high in purity, the eleocharis tuberose peels always regarded as wastes are changed into treasure, chromatographic materials, namely, MCI, polyamide and sol, can be repeatedly used, and the method has the advantages that raw materials are easily available, resources are abundant and the production cost is low; the product can be subjected to large-scale production and meets the needs of pharmaceutical industry.

Being applicable to the field of natural drugs, the invention provides application of a prenylflavanone compound with a structure shown as formula I in the specification in preparation of drugs and health care products for control of bone diseases. Specifically, the prenylflavanone compound comprises a compound 1 with R1 shown as the specification and R2 as H, and a compound 2 with R1 as H and R2 shown as the specification.

The invention belongs to the technical field of chemical industry, and specifically relates to the preparation method and application of five prenyl-containing flavonoid compounds; the compound of the present invention is isolated from the dried roots and rhizomes of Glycyrrhiza uralensis Fisch. in Yongxin Township, Jingyuan County, Gansu Province. It can be isolated by leaching, extraction and column chromatography. The five compounds have significant inhibitory effects on the combination of LAG3 / MHCⅡ or LAG3 / FGL1, which can provide candidate molecules for the development of new anti-tumor drugs, and provide a scientific basis for the development and utilization of Ural licorice (Glycyrrhiza uralensis Fisch.).

The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.

The invention relates to a method for introducing a tertiary isopentenyl group at the C3 position of indole. Specifically, using indole and isoprene as raw materials, under the promotion of rhodium catalyst / phosphine ligand, a tertiary isopentenyl group can be introduced at the C3 position of indole with high selectivity. The present invention has the following advantages: isoprene is a green bulk chemical, simple and easy to obtain, and cheap; simple indole can participate in the reaction without the need to protect NH; no leaving group, atom High economy.

The invention relates to the technical field of medicinal microbial chemistry, and specifically discloses a strain of Bacillus chamois ( Stereum hirsutum ) isolated from the fermentation product of four isopentenyl substituted phenolic compounds for the preparation of antimicrobial drugs, specifically in the preparation of anti-Staphylococcus aureus and methicillin-resistant grape aureus Drug application for cocci growth. The antibacterial activity test of the present invention confirms that isopentenyl substituted phenolic compounds and derivatives thereof of the present invention can significantly inhibit Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (methicillin-resistant Staphylococcus aureus , MRSA), and has the application of preparing new agricultural or medical antibacterial and drug-resistant bacterial drugs.