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Extract of cyclocarya paliurus and application of extract to resisting gout and reducing uric acid

A technology of gout and extraction method, which is applied in the field of extracts of Radix chinensis, can solve the problems of less activity and mechanism research.

Active Publication Date: 2021-07-23
CENT SOUTH UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most studies on the pharmacological activity of prenyl flavonoids of Cyclocarya paliurus focus on hypoglycemic and inflammation, and there are few studies on other activities and mechanisms. Therefore, other application activities and mechanisms of prenyl flavones of Cyclocarya paliurus are specifically clarified It is of great significance to a wide range of clinical applications and innovative drug development

Method used

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  • Extract of cyclocarya paliurus and application of extract to resisting gout and reducing uric acid
  • Extract of cyclocarya paliurus and application of extract to resisting gout and reducing uric acid
  • Extract of cyclocarya paliurus and application of extract to resisting gout and reducing uric acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 1.1 Treatment of Cyclocarya paliurus medicinal materials: Dry leaves of Cyclocarya paliurus (10Kg), crush and extract with 70% ethanol at 120°C under reflux (100L; 2×2h), concentrate at 60°C to obtain extract, and the concentration time is 2 days. The extract was further dispersed with water, extracted with dichloromethane, ethyl acetate, and n-butanol in sequence, 10 L each time, extracted 3 times, and the extract was concentrated at 60°C for 24 hours to obtain extracts and concentrates of different polar parts. liquid.

[0081] The n-butanol part is mainly flavonoids, marked as QQL-HT.

[0082] 1.2 Bioactivity-oriented screening of active parts of Cyclocarya paliurus: Rats were induced with sodium urate to establish an acute gout model to track and screen the active parts of Cyclocarya paliurus n-butanol active parts for improving gout:

[0083] 1.3 Research on active site components

[0084]1.3.1 Extraction, separation and purification of prenyl flavonoids: the pre...

Embodiment 2

[0128] 2.1 Anti-gouty arthritis effect of the active part of Cyclocarya paliurus n-butanol and prenyl flavonoids

[0129] 2.1.1 Experimental method:

[0130] Research on the anti-gouty arthritis effect of QQL-HT: 40 male SD rats qualified for quarantine were selected and randomly divided into 4 groups according to body weight, which were normal control group, model control group, active part group of Cyclocarya paliurus n-butanol, gout Determine the capsule group, with 10 animals in each group. Each group was intragastrically administered with the corresponding medicinal solution, and the normal control group and the model control group were intragastrically administered with the same volume of pure water. 1 time a day, continuous administration for 8 days. Except for the normal control group, the other groups were modeled 30 minutes after administration, SD rats were inhaled anesthetized with isoflurane (1% to 4% for induction, 0.25% to 2% for maintenance), and the knee joi...

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Abstract

The invention relates to an isopentenyl flavonoid compound extracted from cyclocarya paliurus, and particularly discloses an extraction method and application of the isopentenyl flavonoid compound; a structure of the isopentenyl flavonoid compound of the cyclocarya paliurus is as shown in formula I; the isopentenyl flavonoid compounds 1-27 of the cyclocarya paliurus and an n-butyl alcohol active site of the cyclocarya paliurus achieve a relatively good effect in an activity test for preparing a drug for improving gout and reducing uric acid, and are expected to become a new generation of drugs for improving gout and reducing uric acid.

Description

technical field [0001] The invention relates to the extract of Cyclocarya paliurus, in particular to the n-butanol active part and isopentenyl flavonoids of Cyclocarya paliurus, its extraction method and application. Background technique [0002] Cyclocarya paliurus (Bata1) Iljinsk is a plant of the genus Cyclocarya paliurus (Juglaruiaceae) in the family Juglaruiaceae. It is a unique single-species plant in China and is widely distributed in Anhui, Jiangsu, Zhejiang and other places. Since the 1980s, experts and scholars at home and abroad have conducted a lot of research on the resource cultivation, chemical composition, biological activity and product development of Cyclocarya paliurus. The results show that Cyclocarya paliurus has a variety of physiological activities and pharmacological functions beneficial to the human body. [0003] Prenyl flavones are a class of compounds with a prenyl group attached to the flavone core. Compared with flavonoids, they show more promi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H15/26C07H17/07C07H15/18C07H1/08C07J17/00A61P3/10A61P19/02A61P29/00A61P25/28A61P3/06A61P35/00A61P37/04A61P9/12A61P19/06A61K31/7048A61K31/704A61K31/7032B01D11/02
CPCC07H17/07C07H1/08A61P19/06A61K31/7048Y02A50/30
Inventor 徐康平姜德建吴建平朱晖李桂花魏希凡陈祖辉王钰艳刘学武曾宏亮成飞桂瑞何小爱欧赛玉刘翊芊
Owner CENT SOUTH UNIV
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