Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dammarane tetracyclic triterpene compound and anti-gout application thereof

A tetracyclic triterpene and dammarane type technology, applied in the field of Cyclocarya paliurus extract, can solve the problems of activity and mechanism research, and achieve the effect of improving gout and reducing uric acid gout

Active Publication Date: 2021-06-22
CENT SOUTH UNIV +2
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on these two types of ingredients is mostly focused on hypoglycemic and inflammation, and there are few studies on other activities and mechanisms. Clinical application and innovative drug development are of great significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dammarane tetracyclic triterpene compound and anti-gout application thereof
  • Dammarane tetracyclic triterpene compound and anti-gout application thereof
  • Dammarane tetracyclic triterpene compound and anti-gout application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1.1 Qingliu Willow Medicine Treatment: Qingqi Liu dry leaf (10kg), crushing after 70% ethanol 120 ° C, heat reflux extraction (100L; 2 × 2H), concentrated to extract the extract at 60 ° C, concentration time of 2 days. The immersion paste was further dispersed with water, extracted with dichloromethane, ethyl acetate, n-butanol, extracted 3 times each time, extract 60 ° C, concentration time of 24 hours, extraction concentration of different polarity parts, respectively liquid. The dichloromethane site is mainly Damartane tetracelial triterpenoid compound, labeled QQL-ST, and the n-butanol site is mainly flavonoid compound, and is labeled as QQL-HT.

[0050] 1.2 Biological activity guide screening Qingqi willow active part: Using sodium uric acid induced rats to establish an acute gout model to track and screen on the active parts of Qingliu improve gout effects:

[0051] 1.3 ingredient of active site

[0052] 1.3.1 Titerpenoid extraction separation and purification: chemic...

Embodiment 2

[0087] Study on the effect of improving gout in the same life and Damartane tetracene triterpenoids

[0088] 2.1 Anti-pain-resistant arthritis

[0089] 2.1.1 Experimental method:

[0090] Study on the effect of QQL-ST anti-pain: 40 quarantine is 40, male, according to the body weight, randomly divided into 4 groups, respectively, the normal control group, the model control group, the Qingliu dichloromethane active site group , Gouting capsule group, 10 animals per group. Each group was given a corresponding liquid, normal control group and model control group gave a given amount of pure water. 1 time a day, for 8 days. In addition to the normal control group, the remaining groups were treated 30 minutes afterwards, and the SD rats were inhaled with isoflurane (induced by 0.25% to 2%), and the bilateral rear leg knee joint was inhaled. Shaving around, medical alcohol disinfection skin, light curved knee, synthetic side, needle with a syringe No. 6, 0.5ml of uricate solution (25 mg ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a cyclocarya paliurus extract, in particular to a cyclocarya paliurus dichloromethane active site and a dammarane tetracyclic triterpenoid compound as well as an extraction method and application thereof. The structure of the cyclodammarane tetracyclic triterpenoid compound is shown as a formula I or a formula II. The dammarane tetracyclic triterpenoid compound 1-26 and the dichloromethane active part of cyclocarya paliurus have good effects in preparation of activity tests for improving gout and reducing uric acid, and are expected to become a new generation of medicines for improving gout and reducing uric acid.

Description

Technical field [0001] The present invention relates to extracts of Qingqiao, in particular, involving Qingli Liutchloromethane active parts and Darmane tetracycline triterpenoid compounds (including 3, 4-cracked rings and non-cracking loops) and their extraction Method and application. Background technique [0002] Qingliuhua [cyclocaryapaliurus (BATA1) iljinsk] Juglaruiaceae, Qingliracea, is a unique single plant, widely distributed in Anhui, Jiangsu, Zhejiang and other places. Since the 1980s, experts and scholars at home and abroad mainly conducted a lot of research on the cultivation, chemical composition, bioactivity and product development research of Qingqiao willow. The results show that the Qingliu will will willow has a variety of physiological activity and pharmacological functions for human body. [0003] Titerpenoids is a class of important natural products in natural distribution and variety of structural types, with hypoglycemic step-down, anti-inflammatory, lower...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H15/26C07H17/07C07H15/18C07H1/08C07J17/00A61P3/10A61P19/02A61P29/00A61P25/28A61P3/06A61P35/00A61P37/04A61P9/12A61P19/06A61K31/7048A61K31/704A61K31/7032B01D11/02
CPCC07H17/07C07H1/08A61P19/06A61K31/7048Y02A50/30
Inventor 徐康平曾宏亮成飞桂瑞魏希凡朱晖欧赛玉吴建平陈祖辉何小爱王钰艳刘翊芊李桂花
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com