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Cyclocarya paliurus extract and application thereof

A technology of Cyclocarya paliurus and medicine, applied in the field of Cyclocarya paliurus extract, which can solve the problems of activity and mechanism research.

Active Publication Date: 2021-06-22
CENT SOUTH UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on these two types of ingredients is mostly focused on hypoglycemic and inflammation, and there are few studies on the activities and mechanisms of other aspects. The clinical application and innovative drug development are of great significance

Method used

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  • Cyclocarya paliurus extract and application thereof
  • Cyclocarya paliurus extract and application thereof
  • Cyclocarya paliurus extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1.1 Treatment of Cyclocarya paliurus medicinal materials: Dry leaves of Cyclocarya paliurus (10Kg), crush and extract with 70% ethanol under reflux at 120°C (100L; 2×2h), concentrate at 60°C to obtain extract, and the concentration time is 2 days. The extract was further dispersed in water, extracted with dichloromethane, ethyl acetate, and n-butanol in sequence, 10 L each time, extracted 3 times, and the extract was concentrated at 60°C for 24 hours to obtain extracts and concentrates of different polar parts. liquid. The dichloromethane part is mainly dammarane-type tetracyclic triterpenoids, which is the No. 1 active part (also known as the dichloromethane active part), marked as QQL-ST, and the n-butanol part is mainly flavonoids The compound, active site number 2 (also known as the n-butanol active site), was annotated as QQL-HT.

[0066] 1.2 Biological activity-oriented screening of active parts of Cyclocarya paliurus: Use models to track and screen the active pa...

Embodiment 2

[0133] 2.1 Immunity-enhancing activity evaluation of dichloromethane active fraction and n-butanol active fraction of Cyclocarya paliurus

[0134] 2.1.1 Experimental Grouping

[0135] 128 experimental animals, weighing 18-22 grams, were randomly divided into 4 groups after one week of adaptive feeding, with 32 mice in each group. Group 1 was tested for organ / body weight, serum hemolysin, and antibody-producing cells; group 2 was tested for delayed hypersensitivity; groups 3-4 were tested for carbon clearance and peritoneal macrophages phagocytosis of chickens Red blood cell experiment. In the experiment, 150 mg / kg QQL-HT, QQL-ST group and a blank control group were set up, with 8 animals in each group. Before the experiment, the test substance was made into a 10mg / mL suspension with distilled water, and the animals in the corresponding dose group were given intragastric administration according to the volume of 0.2mL / 10g BW, and the blank control group was given the same vol...

Embodiment 3

[0192] The application of the dichloromethane active part and the n-butanol active part of Cyclocarya paliurus in the preparation of lipid-lowering medicine.

[0193] 3.2 Evaluation of lipid-lowering activity

[0194] 3.2.1 Establishment and grouping of hyperlipidemia animal models

[0195] After one week of adaptive feeding, the mice were randomly divided into blank control group and model group. The mice in the model group were gavaged with high-fat emulsion (1 mL / kg), and the mice in the blank control group were gavaged with an equal volume of sterile water. Taking the blank control group as a reference, the mice with successful modeling were selected according to the extremely significant difference in TC value (P<0.01) from the blank group, and they were randomly divided into model control group, QQL-ST group and QQL-HT group. During the experiment, the mice in each group had free access to water and food, and the activities and eating conditions of the animals were obs...

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Abstract

The invention relates to an extract of cyclocarya paliurus, in particular to a No.1 active part and a No.2 active part as well as an extraction method and application thereof. The No.1 active site is a dichloromethane extraction concentrated solution of cyclocarya paliurus; the main component of the No.1 active part is a dammarane type tetracyclic triterpenoid compound. The invention also provides an extraction method of the No.1 active part, the No.2 active part, the dammarane tetracyclic triterpenoid compound and the isopentenyl flavonoid compound. The invention also relates to systematic research on the active ingredients and pharmacodynamic material basis for improving memory, active ingredients and pharmacodynamic material basis for reducing lipid, active ingredients and pharmacodynamic material basis for enhancing immunity and active ingredients and pharmacodynamic material basis for improving memory. Experiments show that the No.1 active part and the No.2 active part can effectively improve memory, lower lipid and enhance immunity. The dammarane tetracyclic triterpenoid compound and the isopentenyl flavonoid compound are used as active components of the dammarane tetracyclic triterpenoid compound and the isopentenyl flavonoid compound, and the effect is also remarkable.

Description

technical field [0001] The invention relates to the extract of Cyclocarya paliurus, in particular to No. 1 active part and No. 2 active part and their extraction method and application. Background technique [0002] Cyclocarya paliurus (Bata1) Iljinsk is a plant of the genus Cyclocarya paliurus (Juglaruiaceae) in the family Juglaruiaceae. It is a unique single-species plant in China and is widely distributed in Anhui, Jiangsu, Zhejiang and other places. Since the 1980s, experts and scholars at home and abroad have conducted a lot of research on the resource cultivation, chemical composition, biological activity and product development of Cyclocarya paliurus. The results show that Cyclocarya paliurus has a variety of physiological activities and pharmacological functions beneficial to the human body. [0003] Triterpenoids (triterpenoids) are a class of important natural products that are widely distributed in nature and have various structural types. Studies have found tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H15/26C07H17/07C07H15/18C07H1/08C07J17/00A61P3/10A61P19/02A61P29/00A61P25/28A61P3/06A61P35/00A61P37/04A61P9/12A61P19/06A61K31/7048A61K31/704A61K31/7032B01D11/02
CPCC07H17/07C07H1/08A61P19/06A61K31/7048Y02A50/30
Inventor 徐康平何小爱曾普华王钰艳陈祖辉陆士娟吴建平曾宏亮成飞朱晖李桂花欧赛玉刘翊芊魏希凡桂瑞
Owner CENT SOUTH UNIV
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