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Icaritin K and preparation method thereof, and application of icaritin K to drugs

A drug, pharmacy technology, applied in the field of pharmaceutical compounds and pharmacology

Pending Publication Date: 2018-03-27
YUNNAN BIOBIAOPHA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there is no report on the formula (I) compound epimedonin K (epimedonin K) involved in the present invention and its report on the treatment of tumors as an active ingredient, and the report that the compound has anti-tumor activity

Method used

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  • Icaritin K and preparation method thereof, and application of icaritin K to drugs
  • Icaritin K and preparation method thereof, and application of icaritin K to drugs
  • Icaritin K and preparation method thereof, and application of icaritin K to drugs

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Effect test

Embodiment 1

[0032] The preparation method and structural characterization of the compound of the present invention:

[0033] 1. Preparation method:

[0034] The Chinese herbal medicine Epimedium is crushed and extracted with alcohol, the extracts are combined and concentrated under reduced pressure to obtain the crude extract extract, which is then separated by silica gel column chromatography and gradient eluted with petroleum ether / acetone solvent system. A component was obtained in the elution section of about 10:1 petroleum ether / acetone. The component is further subjected to gradient elution of silica gel column chromatography, MCI decolorization treatment, and column chromatography such as Sephadex LH-20 to separate the pure epimedonin K (epimedonin K).

[0035] 2. Structural characterization:

[0036] White powder; molecular formula C 30 h 34 o 5 ;ESIMS(pos.):m / z 475[M+H] + ;HRESIMS: m / z 475.2478[M+H] + (475.2485 calcd for C 30 h 35 o 5 ); UV(MeOH)λ max :224(sh),246,274,...

Embodiment 2

[0042] Tablet: 10 mg of the compound obtained in Example 1, 180 mg of lactose, 55 mg of starch, and 5 mg of magnesium stearate;

[0043] Preparation method: mix the compound, lactose and starch, moisten it evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, and press the mixture into tablets, each tablet weighs 250mg, and the compound content is 10mg .

Embodiment 3

[0045] Capsules: 100 mg of the compound obtained in Example 1, 100 mg of starch, and an appropriate amount of magnesium stearate;

[0046] Preparation method: mix the compound and auxiliary agents, sieve, mix uniformly in a suitable container, and fill the obtained mixture into hard gelatin capsules.

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Abstract

The invention relates to an extract of an epimedium plant, i.e., isopentenyl flavonoid with antineoplastic activity and as shown in a formula (I) which is described in the specification, a preparationmethod thereof, a pharmaceutical composition with the isopentenyl flavonoid as shown in the formula (I) as an active component and for treating and preventing tumors, and application of the isopentenyl flavonoid and the pharmaceutical composition to preparation of drugs used for treating and preventing tumors.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compounds and pharmacy, and in particular relates to a new compound epimedonin K (epimedonin K), its preparation method, a pharmaceutical composition with the compound as an active ingredient, the compound and its medicine Application of the composition in the preparation of medicaments for treating tumors. Background technique [0002] Epimedium is a perennial herb with a plant height of 20-60 cm. Produced in Shaanxi, Gansu, Shanxi, Henan, Qinghai, Hubei, and Sichuan, it grows in forests, thickets along ditches, or damp places on hillsides, at an altitude of 650-3500 meters. Epimedium is a commonly used traditional Chinese medicine in my country. The whole herb is used for medicinal purposes. It is mainly used to treat impotence and premature ejaculation, backache and leg pain, numbness of limbs, hemiplegia, neurasthenia, forgetfulness, tinnitus, and dizziness. [0003] Tumor refers to cells under...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P35/00
CPCC07D311/30C07D311/40
Inventor 任福才王飞姜先俊王丽霞李香梅魏国柱
Owner YUNNAN BIOBIAOPHA TECH
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