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Preparation method and application of five prenyl-containing flavonoid compounds

A technology of prenyl flavones and compounds, applied in the field of preparation of prenyl flavones

Active Publication Date: 2022-05-27
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there have been many research results on the components of Ural licorice, the reports on the activity of its secondary metabolites have yet to be supplemented. Therefore, it is hoped to obtain compounds with excellent activity from this source

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  • Preparation method and application of five prenyl-containing flavonoid compounds
  • Preparation method and application of five prenyl-containing flavonoid compounds
  • Preparation method and application of five prenyl-containing flavonoid compounds

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Embodiment 1

[0045] In conjunction with embodiments, the accompanying drawings will further describe the present invention:

[0046] Preparation process

[0047] Glycyrrhiza uralensis Fisch. Dried roots and roots crushed, soaked in 95% methanol 3 times at room temperature for 7 days each time, the extract was concentrated and dispersed in the aqueous phase, three times with petroleum ether, ethyl acetate and n-butanol, and ethyl acetate extract was combined and concentrated to obtain a crude extract.

[0048]The crude extract was separated by macroporous resin by chromatography, and the ethanol-water = 0:100, 30:70, 50:50, 80:20, 100:0 (v / v) gradient elution was obtained by 5 components (Fr.A-E), wherein Fr.A was ethanol-water = 0:100, Fr .B was ethanol-water = 30:70, and Fr .C was ethanol-water = 50 :50, Fr.D is ethanol - water = 80:20, Fr.E is ethanol - water = 100: 0, collection gradient is ethanol - water = 80: 20 (Fr.D) of the elution component; Fr.D is separated by silica gel column chro...

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Abstract

The invention belongs to the technical field of chemical industry, and specifically relates to the preparation method and application of five prenyl-containing flavonoid compounds; the compound of the present invention is isolated from the dried roots and rhizomes of Glycyrrhiza uralensis Fisch. in Yongxin Township, Jingyuan County, Gansu Province. It can be isolated by leaching, extraction and column chromatography. The five compounds have significant inhibitory effects on the combination of LAG3 / MHCⅡ or LAG3 / FGL1, which can provide candidate molecules for the development of new anti-tumor drugs, and provide a scientific basis for the development and utilization of Ural licorice (Glycyrrhiza uralensis Fisch.).

Description

Technical field [0001] The present invention belongs to the field of biochemical technology, specifically relates to five kinds of preparation methods and applications containing isoprenyl flavonoids. Background [0002] Plants are widely distributed and diverse natural resources, many of which have medicinal properties. Natural compounds from plants are rich in structure and activity, and studying the compounds contained in medicinal plants has a certain guiding effect on the discovery of potential drug-ready molecules. Ural licorice (Glycyrrhiza uralensis Fisch.) It is a traditional medicinal plant in China, and is widely used in food, cosmetics and other fields, rich in flavonoids, triterpenes and other types of ingredients, with antiviral, anti-inflammatory, antioxidant and other activities. Although there have been many research results on the composition of Ural licorice, the activity reports of secondary metabolites have yet to be supplemented, so it is hoped that compound...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/58C07D493/04A61K31/352A61K31/353A61P35/00
CPCC07D311/58C07D493/04A61P35/00
Inventor 高坤王柳笛李亚高文颖吴月婷王婧
Owner LANZHOU UNIVERSITY
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