114 results about "ISFET" patented technology

The sensor arrangement includes: a least two sample chambers; at least two potentiometric FET-sensors, especially ISFET-sensors or ChemFET-sensors, having, in each case, a sensitive surface section, wherein each sensitive surface section lies in flow connection with its one of the sample chambers; and a reference cell having a reference medium for providing a reference potential, wherein the sample chambers are connected with the reference medium via an electrolyte bridge. The reference cell has, preferably, a potentiometric reference-FET-sensor for providing a reference potential, which is registered against the pseudo-reference-potential of a redox electrode. The potentials Udiff1, Udiff2, . . . UdiffN of N FET-sensors in the sample chambers are determined against the pseudo-reference-potential, and the measured-variable-relevant, potential differences are determined, in each case, by difference formation between the pertinent potential and the reference potential—thus, in the case of pH, according to the formulasUpH1. . . N=Udiff1. . . N−Udiffref.

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.

One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another embodiment is a method for monitoring tissue pH.

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.

Dual-gate ion-sensitive field effect transistors (ISFETs) for disease diagnostics are disclosed herein. An exemplary dual-gate ISFET includes a gate structure and a fluidic gate structure disposed over opposite surfaces of a device substrate. The gate structure is disposed over a channel region defined between a source region and a drain region in the device substrate. The fluidic gate structure includes a sensing well that is disposed over the channel region. The sensing well includes a sensing layer and an electrolyte solution. The electrolyte solution includes a constituent that can react with a product of an enzymatic reaction that occurs when an enzyme-modified detection mechanism detects an analyte. The sensing layer can react with a first ion generated from the enzymatic reaction and a second ion generated from a reaction between the product of the enzymatic reaction and the constituent, such that the dual-gate ISFET generates an enhanced electrical signal.

Disclosed is an ISFET comprising a H+-sensing membrane consisting of RF-sputtering a-WO3. The a-WO3 / SiO2-gate ISFET of the present invention is very sensitive in aqueous solution, and particularly in acidic aqueous solution. The sensitivity of the present ISFET ranges from 50 to 58 mV / pH. In addition, the disclosed ISFET has high linearity. Accordingly, the disclosed ISFET can be used to detect effluent.

The invention discloses a multichannel ion sensitive field effect transistor (ISFET) sensor array readout circuit with a compensation function. The readout circuit is used for detecting the ion concentration of a solution to be detected, the readout circuit comprises a plurality of ISFET sensor readout circuits, each ISFET sensor readout circuit forms a detection channel, each ISFET sensor readout circuit has a compensating port for receiving compensation signals provided by an external system to modify non ideal characteristics of ISFET sensors. The readout circuit adopts a multichannel detection mode, a plurality of parameters of the ISFET array sensors can be rapidly detected, parallel or serial output can be carried out by the detection mode according to the need of the system.

The present invention relates to a cell-based transparent sensor capable of the real-time optical observation of cell behavior, to a method for manufacturing same, and to a multi-detection sensor chip using same. More particularly, the present invention relates to a cell-based transparent sensor capable of the real-time optical observation of cell behavior, to a method for manufacturing same, and to a multi-detection sensor chip using same, wherein the sensor can sense the ionic concentration of an electrolyte in accordance with the variation in the metabolic activity of cells using an ion-selective field effect transistor (ISFET) sensor and an electrochemical sensor, and the sensor is made of a transparent material which enables real-time observations of optical phenomenon for measurement of cell behavior.

A system, method and apparatus for determining a physiological condition within a mammal based on pH and / or temperature measurements. The invention is for determining vaginal health and / or fertility status in a female mammal based on pH and / or temperature measurements of vaginal and / or cervical fluids or tissue. The invention is suited for taking either in vivo or external measurements. In one aspect, the invention is an apparatus comprising an elongated probe portion and a handle portion. In one embodiment, the circuitry of the apparatus is strategically split between the probe portion and the handle portion to facilitate a plug-and-play type of device. In another embodiment, an elongated probe is provided that has a hermetically sealed internal cavity that houses the circuitry while leaving the temperature sensor and the pH sensor exposed for direct contact with the desired biological fluid. In a further embodiment, an ISFET is used as the pH sensor.