44 results about "Irritable colon" patented technology

Disclosed herein are exendin singly modified with polyethylene glycole or a derivative thereof, a method for the preparation of the same, and uses thereof. Exendin modified at lysine (27) with polyethylene glycol shows biological activity similar to that of natural exendin, but is improved in half life. In addition, the modification position and the number of PEG or its derivative are restricted so as to minimize the side effects caused by a variety of combinations of such factors. The exendin is useful in the prevention and treatment of diseases caused by the over-secretion of insulin, or diseases caused due to a decrease in plasma glucose level, the inhibition of gastric or intestinal motility, the promotion of satiety, or the inhibition of food intake, especially diabetes, obesity and irritable colon syndrome.

The invention discloses a medicament composition for treating spleen-insufficiency diarrhea type irritable bowel syndrome and a preparation method thereof. The medicament composition comprises 20-40 parts of primula sikkmensis hook, 10-20 parts of red ginseng, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 5-15 parts of dried tangerine peel, 5-15 parts of pinellia ternate and 3-6 parts of licorice roots. The preparation method comprises the following steps of: weighing the raw materials in proportion; soaking all raw materials of which the weight is 3-5 times that of water into the water for 1-2 hours; after soaking, adding water of which the weight is 2-3 times that of the raw materials, decocting for 1-1.5 hours, and filtering to obtain a water decoction at a first time after the decoction is finished; adding water of which the weight is 5-8 times that of the raw materials, decocting for 1-1.5 hours and filtering to obtain a water decoction at a second time; and mixing the water decoction at the first time with the water decoction at the second time. The medicament composition is novel in formula, simple in composition and low in cost; the preparation is easy to operate, low in preparation cost and suitable for industrial production; and the medicament is convenient to orally take and carry, has no toxic and side effects and has a good clinical curative effect for patients suffering from the spleen-insufficiency diarrhea type irritable bowel syndrome.

The present invention relates to a method for stereospecifically synthesizing 3-substituted 5-membered ring isomers of formula (A). The final product is useful in the treatment of epilepsy, syncope, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), Medications for inflammation especially arthritis, sleep disorders, PMS, and hot flashes. The present invention provides a method for stereoselectively synthesizing gabapentin (Neurontin) analogues of formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts thereof, wherein R is C1-C10 alkyl Or C3-C10 cycloalkyl.

The invention discloses application of mir-146a-5p to treating visceral hypersensitivity of irritable bowel syndrome. The mir-146a-5p is low in expression in peripheral serum of patients with visceralhypersensitivity of irritable bowel syndrome and intestinal mucosa of disease model mice with irritable bowel syndrome; meanwhile, after the disease model mice of irritable bowel syndrome receive intraperitoneal injection of hsa-mir-146a-5p agomir to achieve high expression of mir-146a-5p, the visceral sensitivity of the disease model mice is significantly reduced, so that the effectiveness of mir-146a-5p on reducing visceral hypersensitivity of the irritable bowel syndrome can be proved, and an effective way for treating visceral hypersensitivity of irritable bowel syndrome can be provided.

Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and / or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

The invention discloses a traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in percentage by weight: 18-19% of coptis root, 14-15% of nutgall, 14-15% of pomegranate rind, 14-15% of myrobalam, 22-23% of astragalus mongholicus, 7-8% of atractylis ovata and 7-8% of radix sileris. The traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry disclosed by the invention has significant curative effects on treating colibacillosis, salmonellosis and other bacterial diarrhea as well as chronic enteritis, irritable colon and other chronic diarrhea of the livestock and poultry. At the same time, the traditional Chinese medicine composition disclosed by the invention has the advantages of low production cost, and small toxic or side effect.