Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases

A composition and technology of Clostridia, applied in the direction of microorganism-based methods, biochemical equipment and methods, metabolic diseases, etc., can solve problems such as unknown organisms, affecting host metabolism and obesity

Pending Publication Date: 2022-03-29
UNIV OF UTAH RES FOUND
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Microbiota influences host metabolism and obesity, but organisms that protect against disease remain unknown

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases
  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases
  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Example 1: T cell-mediated modulation of the microbiota to prevent obesity

[0147] Abstract: The microbiota influences host metabolism and obesity, but the organisms that protect against disease remain unknown. Microbiota-driven age-related development of metabolic syndrome has been observed in studies interrogating immune pathways that regulate microbiota composition. In this model, expansion of Desulfovibrio and loss of Clostridia are important features associated with obesity, and replacement of Clostridia rescues obesity. T cell-dependent events are required to prevent the loss of Clostridia and the expansion of Desulfovibrio. Inappropriate Clostridia IgA targeting and increased Desulfovibrio species antagonize beneficial Clostridia colonization. Transcriptional and metabolic profiling reveals enhanced lipid uptake in obese hosts. Clostridia but not Desulfovibrio colonization of germ-free animals downregulates the expression of genes that control lipid uptake an...

Embodiment 2

[0201] Example 2: Four Clostridium strains rescue obesity, insulin resistance and inflammatory bowel disease

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed herein are compositions comprising clostridium consortia, and methods of treating obesity, metabolic syndrome, irritable bowel disease, and reducing weight gain and inhibiting lipid absorption in the small intestine by administering the compositions to a subject.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of the filing date of U.S. Provisional Application No. 62 / 875,194, filed July 17, 2019. The content of this prior filed application is hereby incorporated by reference in its entirety. [0003] References to Sequence Listings [0004] The sequence listing filed herein as a text file named "21101_0401P1_SL.txt" created on July 16, 2020 and sized at 24,576 bytes is hereby incorporated by reference pursuant to 37 C.F.R. §1.52(e)(5) . Background technique [0005] The microbiota influences host metabolism and obesity, but the organisms that protect against disease remain unknown. Contents of the invention [0006] Disclosed herein are bacterial consortia. Disclosed herein are Clostridium consortia. [0007] Disclosed herein are compositions comprising a supernatant from a Clostridium consortium. [0008] Disclosed herein are compositions comprising a Clostridium consortium. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K35/74A61K35/741A61K35/742A61K35/745A61K45/06
CPCA61K45/06A61K35/742A61K2035/115A61K2300/00A61P3/04A61P3/06A61P3/10A61P29/00A61P1/00A61P9/12C12R2001/145C12N1/20
Inventor J·L·朗德
Owner UNIV OF UTAH RES FOUND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com