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Pharmaceutical preparation and application thereof to preparation of drug for treating depressive disorder and enteritis

A technology for depression and drugs, applied in the field of otilonium bromide and its new pharmaceutical applications, can solve problems such as fatigue, incompetence in work and housework, and laziness in activities

Inactive Publication Date: 2015-07-15
王秀芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] 2. Poor sleep: frequent insomnia, excessive dreams, difficulty falling asleep, or not sleeping deeply, easy to wake up at night or early
[0015] 3. No interest: Not interested in the things I liked to do before, unwilling to participate in social activities, and often stay behind closed doors
[0017] 5. Decreased ability: the work and housework that I was competent in the past are not competent, I always feel tired, and I am too lazy to do activities
[0018] 6. Pessimistic sense of worthlessness: no hope for the future, often feel lonely, hopeless, fearful and helpless, often blame themselves, sometimes have suicidal thoughts

Method used

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  • Pharmaceutical preparation and application thereof to preparation of drug for treating depressive disorder and enteritis
  • Pharmaceutical preparation and application thereof to preparation of drug for treating depressive disorder and enteritis
  • Pharmaceutical preparation and application thereof to preparation of drug for treating depressive disorder and enteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Observation of the clinical efficacy of otilonium bromide in the treatment of post-stroke depression

[0041] 1 Materials and methods

[0042] 1.1 Clinical data

[0043] A total of 52 patients with post-stroke depression were selected from June 2014 to December 2014, including 25 males and 27 females; aged 51-70 years, with an average age of (58.6±6.1) years; course of disease 4-12 years old months, with an average of (6.5±2.3) months. All patients were diagnosed with stroke by head CT and MRI, and met the CCMD-3 depression diagnostic criteria, and the Hamilton Depression Rating Scale (HAMD) score was ≥20 points.

[0044] Those who took antidepressant drugs recently, those who were allergic to otilonium bromide, those with subarachnoid cerebral hemorrhage, brain tumor and other nervous system diseases, and those with a history of mental illness were excluded.

[0045] They were randomly and evenly divided into observation group and ...

Embodiment 2

[0078] Embodiment 2: Experimental study on the efficacy of otilonium bromide in the treatment of depression

[0079] 1 material

[0080] 1. 1 Drugs

[0081] (1) The drug under test (otilonium bromide tablets): Jincheng Hayes Pharmaceutical Co., Ltd., approved by the State Drug Administration H20066490.

[0082] (2) Positive control drug (fluoxetine hydrochloride tablets): Changzhou Siyao Pharmaceutical Co., Ltd., National Pharmaceutical Approval H19980139.

[0083] 1. 2 Animals

[0084] ICR male mice, weighing 18-22 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number SCXK (Beijing) 2014-0035. All animals were purchased 1 week in advance and fed routinely.

[0085] 1. 3

[0086] Instruments Medlab biological signal acquisition system (Nanjing Yimei Technology Co., Ltd.), JZ100 100g tension transducer (Gaobeidian Xinhang Electromechanical Equipment Co., Ltd.), Sony DSC2P8 digital camera (Shanghai...

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Abstract

The invention relates to the technical field of chemical drugs, discloses a pharmaceutical preparation and application thereof to preparation of a drug for treating depressive disorder and enteritis and relates to an otilonium bromide drug and application thereof to preparation of a drug for treating depressive disorder, post-stroke depression, depressive episode, chronic enteritis, irritable bowel syndrome and intestinal spasm. The otilonium bromide drug provided by the invention is an otilonium bromide tablet, an otilonium bromide capsule, an otilonium bromide enteric-coated tablet and an otilonium bromide enteric capsule. According to the technology provided by the invention, the clinical application range of otilonium bromide is widened, and meanwhile, a novel medication choice and a novel clinical diagnosis and treatment scheme are provided for treating diseases such as depressive disorder, post-stroke depression, depressive episode, chronic enteritis, irritable bowel syndrome and intestinal spasm.

Description

technical field [0001] The invention relates to the technical field of chemical medicines, in particular to an otilonium bromide medicine and its new pharmaceutical application. Background technique [0002] Post-stroke depression is one of the common complications of stroke. Severe patients may have the idea of ​​committing suicide, if not prevented in time, some patients may lead to the consequences of suicide. It is an affective disorder disease that is related to stroke events and clinically manifests depressed mood. [0003] 1. Symptoms of depression [0004] At least 40% to 50% of stroke patients experience depression after stroke, most of which occur 2 months to 1 year after stroke. Because the occurrence of depressive reactions is very hidden and difficult to be detected, some patients cannot be detected due to language barriers, and they often do not know until after the accident. If you have known the manifestations of depression early and paid more attention ...

Claims

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Application Information

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IPC IPC(8): A61K31/245A61P25/24A61P1/00A61P1/06
Inventor 王莉丁丽曼刘玲吴平安
Owner 王秀芹
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