118 results about "Injection force" patented technology

Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

There is provided an injection molding machine provided with an injection mechanism that enables a high-speed injection.The injection molding machine includes: a heating barrel for melting and kneading a resin fed from a hopper, said barrel having an injection nozzle at its front end; a screw movably and rotatably inserted in the heating barrel; a screw drive shaft coupled at its one end to the rear end of the screw; charging means including a charging motor for rotationally driving the screw drive shaft to rotate the screw so as to melt the resin in the heating barrel while conveying the resin forward of the screw, and measure the volume of the molten resin, and torque transmission means for transmitting the driving torque of the charging motor to the screw drive shaft and permitting a displacement of the screw drive shaft in the axial direction; a body frame fixing and supporting the charging motor and the torque transmission means, said frame including a front plate fixing and supporting the base of the heating barrel; injection drive means including a linear-movement shaft coupled to the rear end of the screw drive shaft and movable in the axial direction, and an injection motor for advancing the screw and producing an injection force for injecting the molten resin in the heating barrel; and shaft coupling means for coupling the rear end of the screw drive shaft to the linear-movement shaft such that only a thrust in the axial direction is transmitted to the screw drive shaft.

Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

A skin retention device 10 for a medical jet-injection unit 20 comprises a contact face provided with adhesive 12 in the area surrounding and close to the injection opening(s) 11 of the nozzle 21 which ensures god contact between the nozzle 21 and the skin 30 of a subject in the area chosen for an injection. Consequently the injection force can be lowered dramatically. In case of two-stage jet-injections, the initial injection force can be lowered because the skin retention close to the injection point significantly reduces the energy consuming elastic expansion of the skin 30 in the injection area, and the second injection force can be lowered because of the high degree of fixed positioning of the injection opening of the nozzle 21 relative to the injection channel in the skin 30 made during the initial injection stage. Thus a high degree of injection safety is achieved, minimizing the risk of whet shots, while skin lift and lower injection force decreases the risk of damage of the underlying tissue.