59 results about "Fexofenadine Hydrochloride" patented technology

The present invention relates to a pharmaceutical formulation of fexofenadine hydrochloride in a solvent system suitable as a liquid fill composition. In another aspect, the invention also relates to a process for the preparation of the said pharmaceutical formulation and the use of said composition for the preparation of a drug for the treatment of allergic reactions in a patient.

The invention discloses a fexofenadine hydrochloride orally disintegrating tablet, which consists of fexofenadine hydrochloride, a composite disintegrating agent, a filling agent, a lubricating agent and a composite flavoring agent. The fexofenadine hydrochloride orally disintegrating tablet is characterized in that the composite disintegrating agent is a highly efficient disintegrating agent, the highly efficient disintegrating agent is added internally and externally; and the composite flavoring agent is also added internally and externally. The orally disintegrating tablet of the inventionhas more excellent quality, can completely disintegrate in the oral cavity within 30 seconds, and has no gravel sense and no bitterness, and the dissolution can be more than 80 percent when determining the dissolution with water as the medium for ten minutes.

The present invention relates to pharmaceutical compositions of antihistamine-decongestant combination. Specifically the invention relates to bilayered tablet formulation comprising antihistaminic decongestant combination. More specifically present invention relates to the novel polymorph of fexofenadine or pharmaceutically accepted salts thereof, with at least one decongestant in the form of bilayered tablet. The preferred polymorphs are polymorph A and polymorph X of fexofenadine hydrochloride.

The invention discloses a fexofenadine hydrochloride tablet and a preparation method thereof. The preparation is prepared from solid dispersion and pharmaceutical acceptable auxiliary materials by the procedures of evenly mixing and directly tabletting, wherein the solid dispersion is obtained by dissolving fexofenadine hydrochloride and citric acid into ethanol, drying and removing ethanol. According to the tablet disclosed by the invention, the dosage of a disintegrating agent is reduced under the premise of ensuring that the drug is rapidly dissolved out; the production cost is reduced; meanwhile, the fexofenadine hydrochloride tablet is simple in preparation technology, and good in surface after accelerated inspection.

The present invention provides a fexofenadine hydrochloride oral disintegrating drug composition. The fexofenadine hydrochloride oral disintegrating drug composition has characteristics of good stability, high bioavailability, and cost reducing. With the fexofenadine hydrochloride oral disintegrating drug composition of the present invention, the industrialization is achieved, the good clinical application is provided, and the obvious advantage is provided.

The invention discloses a synthetic process of fexofenadine hydrochloride. The synthetic process of fexofenadine hydrochloride comprises the following steps of: with alpha, alpha-dimethyl phenylacetic acid as a raw material, carrying out an esterification reaction on alpha, alpha-dimethyl phenylacetic acid and absolute ethyl alcohol under the catalysis of a silica gel loaded phosphotungstic acid (PW12 / SiO2) solid acid catalyst to obtain alpha, alpha-dimethyl ethyl phenylacetate; carrying out Friedel-Grafts reaction on alpha, alpha-dimethyl ethyl phenylacetate and 4-chlorobutyryl chloride to obtain alpha, alpha-dimethyl-4-(4-chloro-1-oxo butyl) ethyl phenylacetate; reducing by virtue of sodium borohydride in 95% ethyl alcohol to obtain alpha, alpha-dimethyl-4-(4-chloro-1-hydroxyl butyl) ethyl phenylacetate; and carrying out N-alkylation reaction on alpha, alpha-dimethyl-4-(4-chloro-1-hydroxyl butyl) ethyl phenylacetate and alpha, alpha-dimethyl-4-piperidine methyl alcohol in DMF (dimethyl formamide) for 24 hours at the temperature of 80 DEG C to obtain alpha, alpha-dimethyl-4-[1-hydroxyl-4-[4-(hydroxyl diphenylmethyl)-1-piperidyl]-butyl] ethyl phenylacetate, and then carrying out alkali hydrolysis and salification by virtue of hydrochloric acid, so that fexofenadine hydrochloride is obtained. The synthetic process of fexofenadine hydrochloride is high in yield and low in cost, produces less pollution and is applicable to industrial mass production.

The invention relates to a composition of fexofenadine hydrochloride and microcrystalline cellulose. On the basis of totally manufacturing 1000 chips, the composition comprises the following components: 60 grams of the fexofenadine hydrochloride, 66 grams of the microcrystalline cellulose, 34 grams of starch, 10 grams of sodium carboxymethyl cellulose, proper quantity of 5-pecent povidone ethanolsolution, and 0.8 gram of magnesium stearate; and on the basis of totally coating 1000 film coats, the composition comprises the following components: 0.67 gram of hydroxypropyl methylcellulose, 0.33milliliter of propylene glycol, 800.33 milliliters of polysorbate, 0.67 gram of titanium dioxide, 26.7 milliliters of 95-percent ethanol and 6.67 milliliters of purified water. The method for preparing the composition comprises staged production steps. As both the microcrystalline cellulose and the starch have high fluidity and compressibility and can accelerate disintegration of tablets, the microcrystalline cellulose and the starch are selected and used on the basis of determining the used amount of the fexofenadine hydrochloride; and the sodium carboxymethyl cellulose is selected as a disintegrating agent, has higher disintegration and higher compressibility, and is an excellent disintegrating agent for the tablets.