Fexofenadine hydrochloride dry suspension and preparation method thereof
A technology of fexofenadine hydrochloride and dry suspension, which is applied in the field of fexofenadine hydrochloride dry suspension and its preparation, can solve problems such as excessive flavoring agent content, and achieve good suspending property, Good for storage and good taste
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Embodiment 1
[0042] The prescription of fexofenadine hydrochloride dry suspension is as follows in Table 1:
[0043] Table 1 embodiment 1 fexofenadine hydrochloride dry suspension prescription
[0044]
[0045]
[0046] Prepared by the following preparation method:
[0047] (1) Weigh sodium dioctyl sulfosuccinate and ethyl cellulose according to the recipe quantity, and use absolute ethanol to prepare an ethanolic solution containing dioctyl sulfosuccinate sodium and ethyl cellulose, wherein ethyl cellulose The percentage of the total mass of the solution is 10%, and the percentage of the sodium dioctyl sulfosuccinate to the total mass of the solution is 0.68%;
[0048] (2) take by weighing fexofenadine hydrochloride and sucrose according to the recipe quantity, place in a wet granulator, after mixing, add above-mentioned ethyl cellulose / dioctyl sulfosuccinate sodium ethanolic solution for granulation, and make The obtained soft material is sieved and dried, and then sieved to gran...
Embodiment 2
[0051] The prescription of fexofenadine hydrochloride dry suspension is as follows in Table 2:
[0052] Table 2 embodiment 2 fexofenadine hydrochloride dry suspension prescription
[0053] prescription composition % of mass fexofenadine hydrochloride 5.00 sucrose 93.17 Ethyl cellulose 0.50 Dioctyl Sodium Sulfosuccinate 0.04 Xanthan Gum 1.07 Colloidal silica 0.22
[0054] The preparation steps are the same as those in Example 1.
Embodiment 3
[0056] The prescription of fexofenadine hydrochloride dry suspension is as follows in Table 3:
[0057] Table 3 embodiment 2 fexofenadine hydrochloride dry suspension prescription
[0058]
[0059]
[0060] The preparation steps are the same as those in Example 1.
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