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Pharmaceutical composition with fexofenadine hydrochloride and preparation method of pharmaceutical composition

A technology of fexofenadine and its composition, which is applied in the field of medicine and can solve problems such as difficult control of disintegration time limit and dissolution rate, inconvenient production, storage and transportation, and complicated preparation process

Active Publication Date: 2014-03-05
ZHEJIANG WAN SHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Orally disintegrating tablets are required to be high-efficiency and low-dose drugs, not suitable for drugs with a strong bitter taste or pungent taste. The preparation process is complicated, and the disintegration time limit and dissolution rate are difficult to control. Chen Bengao
Although the oral suspension overcomes the above disadvantages, preservatives must be added to the oral suspension to prevent the growth of bacteria, and it is inconvenient to produce, store and transport

Method used

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  • Pharmaceutical composition with fexofenadine hydrochloride and preparation method of pharmaceutical composition
  • Pharmaceutical composition with fexofenadine hydrochloride and preparation method of pharmaceutical composition
  • Pharmaceutical composition with fexofenadine hydrochloride and preparation method of pharmaceutical composition

Examples

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Effect test

Embodiment 1

[0026] Product prescription (Table 1):

[0027]

[0028]

[0029] A total of 1000 bags of production process: pass fexofenadine hydrochloride and suspending agent through an 80-mesh sieve, pass each component of filler, sweetener, flavor and glidant through a 100-mesh sieve, and pass the sieved ingredients Mix evenly and dispense.

Embodiment 2

[0031] Product prescription (Table 2):

[0032]

[0033] A total of 1000 bags of production process: pass fexofenadine hydrochloride and suspending agent through an 80-mesh sieve, pass each component of filler, sweetener, flavor and glidant through a 100-mesh sieve, and pass the sieved ingredients Mix evenly and dispense.

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PUM

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Abstract

The invention relates to a pharmaceutical composition with fexofenadine hydrochloride. The composition is composed of the following components: 1-12% of fexofenadine hydrochloride as an active ingredient, 1-10% of suspending aid, 5-85% of filler, 1-10% of sweetening agent, 0.01-10% of essence and a conventional amount of flow aid, wherein the composition exists in a form of a dry suspension. The fexofenadine hydrochloride suspension provided by the invention has the advantages of high dispersity, uniformity in distribution, rapidness in absorption, high bioavailability, good taste, stability and the like.

Description

technical field [0001] The invention relates to medicines, in particular to a new dosage form of fexofenadine hydrochloride and a preparation method thereof. Background technique [0002] [0003] CAS registration number: 138452-21-8 [0004] Fexofenadine, the active metabolite of terfenadine, is a potent H1 receptor antagonist without the cardiotoxicity of its predecessor. In addition to blocking H1 receptors, studies in vitro and in vivo have also shown that fexofenadine can induce allergic inflammatory reactions mediated by mast cells, basophils, epithelial cells, eosinophils and lymphocytes. Fexofenadine has been shown to have anti-inflammatory activity and to inhibit the expression of ICAM-1 on nasal epithelial cells in vitro. For the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. [0005] The traditional dosage forms of fexofenadine for clinical selection include capsules, tablets, orally disintegrating tablets, and oral suspensions. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/445A61P37/08A61P11/02A61P17/00
Inventor 金璐杜军单瑞平桂盼蒋定宇杨必伟
Owner ZHEJIANG WAN SHENG PHARMA CO LTD
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