Naringin and fexofenadine hydrochloride drug composition and preparation thereof

A composition and technology of naringin, applied in the field of naringin pharmaceutical composition and preparation thereof, can solve problems such as adverse reactions, death and the like

Inactive Publication Date: 2014-12-10
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dextromethorphan is safe and effective in suppressing cold symptoms when used correctly in small doses, but overuse can cause death and other serious adverse effects such as brain damage, seizures, loss of consciousness and irregular heartbeats, the U.S. Food and Drug Administration said.

Method used

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  • Naringin and fexofenadine hydrochloride drug composition and preparation thereof
  • Naringin and fexofenadine hydrochloride drug composition and preparation thereof
  • Naringin and fexofenadine hydrochloride drug composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Inhibition of cough in guinea pigs caused by citric acid

[0013] 1. Materials

[0014] 1.1 Experimental animals Qualified Hartley guinea pigs, weighing 250-300g, male and female, were provided by the Guangdong Medical Experimental Animal Center.

[0015] 1.2 Drugs and reagents: Huifeining; naringin is prepared according to the daily dosage of 120 mg; fexofenadine hydrochloride is prepared according to the daily dosage of 6 mg; the composition (1) group is prepared according to the daily dosage of 27.5 mg of naringin and fexofenadine hydrochloride. 30 mg of phenadine was prepared; the composition (2) group was prepared according to the daily dosage of naringin 27.5 mg and fexofenadine hydrochloride 300 mg; the composition (3) group was prepared according to the daily dosage of naringin 275 mg and fexofex hydrochloride Natin 30mg preparation; composition (4) group is prepared according to human daily dosage of naringin 275mg, fexofenadine hydrochloride 300mg;...

Embodiment 2

[0027] Example 2: Effects on Mouse Phenol Red Excretion Experiment

[0028] 1. Materials

[0029] 1.1 Experimental animals Kunming mice, half male and half male, weighing 30-40 g, were provided by the Guangdong Medical Experimental Animal Center.

[0030] 1.2 Drugs and reagents Ambroxol; naringin is prepared according to the daily dosage of 120 mg; fexofenadine hydrochloride is prepared according to the daily dosage of 120 mg; the composition (1) group is prepared according to the daily dosage of naringin 27.5 mg, fexofox 30 mg of phenadine was prepared; the composition (2) group was prepared according to the daily dosage of naringin 27.5 mg and fexofenadine hydrochloride 300 mg; the composition (3) group was prepared according to the daily dosage of naringin 275 mg and fexofex hydrochloride Natin 30mg preparation; composition (4) group is prepared according to human daily dosage of naringin 275mg, fexofenadine hydrochloride 300mg; composition (5) group is prepared according ...

Embodiment 3

[0043] Example 3: Effect on Allergic Cough (Cough Variation Asthma) Induced by Ovalbumin

[0044] 1. Materials

[0045] 1.1 Experimental animals: Hartley guinea pig, male, weighing 250-300 g, SPF grade, provided by Guangdong Medical Experimental Animal Center.

[0046]1.2 Drugs and reagents Cyclophosphamide; Ovalbumin; Capsaicin; Methacholine; Aoting cough syrup (compound codeine phosphate solution); The daily dose of human is 120 mg; the composition (1) group is prepared according to the daily dose of naringin 27.5 mg and fexofenadine hydrochloride 30 mg; the composition (2) is prepared according to the daily dose of naringin 27.5 mg and fexofenadine hydrochloride 300 mg of phenadine was prepared; the composition (3) group was prepared according to the daily dose of naringin 275 mg and fexofenadine hydrochloride 30 mg; the composition (4) group was prepared according to the daily dose of naringin 275 mg and fexofenadine hydrochloride Ding 300mg preparation; composition (5) ...

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Abstract

The invention relates to a naringin drug composition for relieving cough, eliminating phlegm and relieving asthma and a preparation thereof. The naringin drug composition is characterized in that the naringin drug composition contains naringin and fexofenadine hydrochloride, the content per unit of the naringin in each compounding agent (preparation) is 27.5-275 mg, and the content per unit of the fexofenadine hydrochloride is 30-300 mg; in the composition, the preferred mass ratio of the naringin to the fexofenadine hydrochloride is 1 to 1, and the preferred dosage of the naringin and the fexofenadine hydrochloride in each compounding agent (preparation) are 40 mg and 40 mg respectively. The naringin drug composition and the preparation thereof have the benefits that with the adoption of the drug composition, the cough and the phlegm caused by various reasons as well as the cough variant asthma can be treated; the drug composition can be added with conventional excipients and then can be prepared into a drug for relieving cough, eliminating phlegm and relieving asthma by adopting any conventional methods; the drug effect generated by the composition is better than that generated when the naringin or the fexofenadine hydrochloride is independently used.

Description

technical field [0001] The invention relates to a naringin medicinal composition and preparation thereof for relieving cough, reducing phlegm and relieving asthma. Background technique [0002] Cough and expectoration are two common symptoms of respiratory system diseases, which are closely related pathologically. Generally, cough with more phlegm, and more phlegm often causes cough. Cough variant asthma refers to a special type of asthma with chronic cough as the main or only clinical manifestation. [0003] At present, the most widely used antitussive drugs in pharmaceutical drugs include codeine phosphate and dextromethorphan hydrobromide. [0004] Codeine phosphate is a central nervous system chemical widely used to relieve coughs or colds. However, in recent years, due to its serious adverse reactions, its management level has been repeatedly raised by the State Food and Drug Administration. Common adverse reactions are: psychopathy or fantasy; weak, slow or irregular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/14A61P11/10A61P11/06A61P29/00A61K31/445
CPCA61K31/445A61K31/7048
Inventor 苏薇薇焦豪妍廖彦李沛波彭维王永刚
Owner SUN YAT SEN UNIV
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