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A traditional Chinese medicine polysaccharide composition for anti-cartilage degeneration and its preparation method

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine, can solve the problems of lack of reliable curative effect, safe and convenient treatment methods, etc., and achieve the effects of enhancing chondrocyte activity, delaying cartilage degeneration and excellent curative effect

Active Publication Date: 2018-12-21
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many clinical treatment methods for osteoarthritis, there is a lack of reliable, safe, convenient and low-cost treatment methods

Method used

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  • A traditional Chinese medicine polysaccharide composition for anti-cartilage degeneration and its preparation method
  • A traditional Chinese medicine polysaccharide composition for anti-cartilage degeneration and its preparation method
  • A traditional Chinese medicine polysaccharide composition for anti-cartilage degeneration and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The raw materials of the traditional Chinese medicine polysaccharide composition described in this example consist of the following traditional Chinese medicines in parts by weight: 20 parts of rehmannia glutinosa, 5 parts of peony, 5 parts of Eucommia, and 15 parts of Achyranthes bidentata.

[0020] The preparation method of traditional Chinese medicine polysaccharide composition comprises the following steps:

[0021] 1) Weigh each traditional Chinese medicine according to the above parts by weight, put it in the same extraction container, and set aside.

[0022] 2) Add 50% ethanol at a volume concentration 10 times the mass of medicinal materials, heat and reflux for extraction 3 times, 0.5 h each time, filter with suction, discard the filtrate, dry the medicinal materials, and remove all ethanol.

[0023] 3) Add water with 5 times the mass of medicinal materials, heat and decoct for extraction 3 times, 0.5 h each time, filter, and concentrate the filtrate under redu...

Embodiment 2

[0027] The raw materials of the traditional Chinese medicine polysaccharide composition described in this example consist of the following traditional Chinese medicines in parts by weight: 12 parts of rehmannia glutinosa, 12 parts of peony, 9 parts of Eucommia, and 9 parts of Achyranthes bidentata.

[0028] The preparation method of traditional Chinese medicine polysaccharide composition comprises the following steps:

[0029] 1) Weigh each traditional Chinese medicine according to the above parts by weight, put it in the same extraction container, and set aside.

[0030] 2) Add 95% ethanol at a volume concentration 20 times the mass of medicinal materials, heat and reflux for extraction once, 2 hours each time, filter with suction, discard the filtrate, dry the medicinal materials, and remove all ethanol.

[0031] 3) Add water with 8 times the mass of medicinal materials, heat and decoct to extract twice, each time for 1.5 h, filter, and concentrate the filtrate under reduced...

Embodiment 3

[0035] The raw materials of the traditional Chinese medicine polysaccharide composition described in this example consist of the following traditional Chinese medicines in parts by weight: 5 parts of rehmannia glutinosa, 20 parts of peony, 10 parts of Eucommia, and 10 parts of Achyranthes bidentata.

[0036] The preparation method of traditional Chinese medicine polysaccharide composition comprises the following steps:

[0037] 1) Weigh each traditional Chinese medicine according to the above parts by weight, put it in the same extraction container, and set aside.

[0038] 2) Add 80% ethanol at a volume concentration of 5 times the mass of medicinal materials, heat and reflux extraction twice, 1 hour each time, filter with suction, discard the filtrate, dry the medicinal materials, and remove all ethanol.

[0039] 3) Add 10 times the mass of medicinal material in water, heat and decoct to extract once, 1 hour each time, filter, and concentrate the filtrate under reduced pressu...

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Abstract

The invention relates to a traditional Chinese medicinal polysaccharide composition used for resisting cartilage degeneration and a preparation method of the traditional Chinese medicinal polysaccharide composition, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicinal polysaccharide composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 2-20 parts of radix rehmanniae praeparata, 2-20 parts of peony root, 1-15 parts of cortex eucommiae, and 1-15 parts of radix achyranthis bidentatae. The preparation method comprises the steps of mixing, extracting, separating and purifying, and thus the active ingredients are obtained. The traditional Chinese medicinal polysaccharide composition has the functions of supplementing the cartilage matrix ingredients, enhancing the cartilage cell viability, and delaying the cartilage degeneration. The traditional Chinese medicinal polysaccharide composition has the advantages that the raw materials are easily available, the preparation method is simple and convenient, and the effect in resisting the cartilage degeneration is obvious.

Description

technical field [0001] The invention relates to a traditional Chinese medicine polysaccharide composition for anti-cartilage degeneration and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Osteoarthritis is a common chronic and progressive bone and joint disease among middle-aged and elderly people. With the aging of the population, the incidence rate increases year by year, seriously affecting the quality of life of patients, and has become a serious public health problem. Cartilage degeneration is the fundamental pathological feature of osteoarthritis. With aging, chondrocyte dysfunction causes cartilage degeneration. Chondrocytes are the only cells in articular cartilage, which can adjust the functional state of chondrocytes according to changes in the microenvironment of articular cartilage, thereby maintaining the physical and chemical properties of articular cartilage. Chondrocytes synthesi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715C08B37/00A61P19/08A61K36/804A61K36/71A61K36/65A61K36/46A61K36/21
CPCA61K31/715A61K36/21A61K36/46A61K36/65A61K36/71A61K36/804C08B37/0003A61K2300/00
Inventor 李西海曾建伟梁文娜马玉环郑文伟郑春松许惠凤叶蕻芝刘献祥
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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