74 results about "Estrogens catechol" patented technology

Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.

There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate.

Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.

The present disclosure describes Cephem compounds of the formula:wherein,X is N, CH or C—Cl;T is S or the like;A and G are lower alkylene or the like;B is a single bond or the like;D is optionally present, and when present is, —NR7—, —CO—, —CO—NR7—, —NR7—CO—, —NR7—CO—NR7—, or the like;F is optionally present, and when present is or phenylene;R3 and R4 are —OR8;R5 and R6 each is independently hydrogen, halogen, nitrile, or —OR8;or an ester at the carboxyl at the 7-position side chain or at the 4-position, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria.

The invention provides a dihydromyricetin-containing plant extract and application thereof as a superactive catechol methylation transferase inhibitor. The dihydromyricetin-containing plant extract is applicable as a synergist of a medicine levodopa treating Parkinson's syndrome. In-vitro activity determination shows that IC50 of the plant extract inhibiting catechol methylation transferase can reach the micro-mole to nano-mole grade. Rat integral pharmacokinetic research shows that combined usage of dihydromyricetin and levodopa containing the dihydromyricetin-containing plant extract can substantially improve the plasma concentration of levodopa. Additionally, dihydromyricetin and the dihydromyricetin-containing plant extract are high in safety, do not generate active intermediates through metabolism activation, do not combine with a biomacromolecule to form a toxic adduct, and therefore dihydromyricetin and the dihydromyricetin-containing plant extract do not cause liver and kidney toxicity, and are expected to have good application prospect in auxiliary treatment of Parkinson's syndrome.

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof wherein A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.

The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I):wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

The invention provides compounds of formula I:and salts thereof wherein R1-R4 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.