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Bleed-free injection needle coated with crosslinked chitosan having introduced catechol group and oxidized catechol group

A catechol group and injection needle technology, which is applied in the field of hemostatic injection needles, can solve the problems of not fully satisfying adhesion strength persistence, low toxicity in vivo immune response, etc.

Inactive Publication Date: 2018-01-02
INNO THERAPY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the formulations as described above are forms developed in consideration of the convenience of surgery, and have problems that cannot fully satisfy adhesion strength, persistence after administration, low toxicity, immune response in vivo, etc.

Method used

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  • Bleed-free injection needle coated with crosslinked chitosan having introduced catechol group and oxidized catechol group
  • Bleed-free injection needle coated with crosslinked chitosan having introduced catechol group and oxidized catechol group
  • Bleed-free injection needle coated with crosslinked chitosan having introduced catechol group and oxidized catechol group

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0076] Preparation Example 1: Preparation of Chitosan Introducing Catechol

[0077]

[0078] 3 g of about 30% acetylated chitosan (chitosan 70 / 100, model: 24204, manufactured by Heppe Medical Chitosan) was dissolved in 292 mL of HCl solution (pH=2) for 6 hours. The chitosan solution was adjusted to pH 5.5 by slowly adding 8 mL of 0.5 N NaOH solution thereto. The prepared 1% chitosan solution was stabilized for 12 hours.

[0079] 2.37 g of 3-(3,4-dihydroxyphenyl)propionic acid was added to the prepared chitosan solution. Then, as the amine (-NH 2 ) group and the amide bond (-CONH-) between the carboxyl group (-COOH) of 3-(3,4-dihydroxyphenyl) propionic acid -Dimethylaminopropyl)carbodiimide (EDC) was dissolved in 50 mL ethanol and added to the chitosan solution. Next, the solution was adjusted to pH 4.5, followed by reaction for 1 hour. In this process, catechol-functionalized chitosan was prepared.

[0080]In order to remove unreacted 3-(3,4-dihydroxyphenyl) propion...

Embodiment 1

[0081] Embodiment 1: Manufacture of hemostatic injection needle (26G) 1

[0082] 1.5 mL of the catechol-functionalized chitosan prepared in Preparation Example 1 was dissolved in 100 μL of triple distilled water, and then stored at 4° C. for 3 days to induce partial oxidation and crosslinking of catechol groups. As a result, a chitosan solution (hereinafter referred to as "chitosan-catechol solution") was prepared in which catechol groups were introduced and oxidized catechol groups and partially cross-linked.

[0083] The absorbance at a wavelength of 500 nm was measured by UV-Vis spectroscopy to determine the degree of oxidation of catechol groups in chitosan-catechol solutions. Absorbance at a wavelength of 500 nm occurs when crosslinks between the oxidized catechol groups and the amine groups of chitosan are formed. Therefore, based on the absorbance that occurs, NaIO 4 (ie, an oxidizing agent that induces the oxidation of the chitosan-catechol solution to the high...

Embodiment 2

[0085] Embodiment 2: Manufacture of hemostatic injection needle (23G) 1

[0086] A hemostatic injection needle was manufactured in the same manner as described in Example 1, except that a 23G thick injection needle was used instead of a 26G thick injection needle, and a chitosan-catechol solution in an amount of 9 μL was used instead of 6.5 μL.

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Abstract

The present invention relates to a bleed-free injection needle coated with crosslinked chitosan having an introduced catechol group and oxidized catechol group, and the bleed-free injection needle according to the present invention is advantageous in that said needle can suppress the bleeding that occurs during an injection and hence can beneficially be used not only in patients having reduced hemostatic capacity such as diabetic patients, anticancer therapy patients and haemophilia patients but also in patients exhibiting blood rejection reactions and in injections to children as well.

Description

technical field [0001] The present invention relates to a hemostatic injection needle coated with chitosan into which catechol groups and oxidized catechol groups are introduced and cross-linked. Background technique [0002] The development of conventional hemostatic and adhesive products has been focused on their use in surgical procedures. Typical medical hemostats and adhesives include FDA-approved cyanoacrylate-based adhesives and fibrin glues based on in vivo blood clotting proteins. However, such hemostatic and adhesive products cannot satisfy all of adhesive strength, durability after administration, low toxicity, immune response in vivo, and the like. Therefore, in the development of hemostatic agents, the development of materials that are biocompatible while having excellent adhesion to tissues has become an important issue. [0003] Meanwhile, chitosan is a well-known biopolymer with excellent hemostatic ability. However, chitosan has the disadvantage that it h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L24/00A61L24/08
CPCA61L31/145A61L31/16A61L31/10A61L31/14A61L2300/236A61L2400/04A61L2420/02C08L5/08
Inventor 李海臣申美京李汶修吴硕松
Owner INNO THERAPY INC
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