90 results about "Epulis" patented technology

The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and / or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and / or antimicrobial active agent is an organohalide such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.

The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and / or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and / or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.

The present invention relates to the formulations of ester derivatives of sandalwood oil and santalol. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The compounds of the present invention are set forth by the following formula:The present invention generally pertains to a compound of formula (I):R—CO—SWO  (I)wherein SWO refers to collectively the alcohols, including santalol, present in the sandalwood oil; wherein R is selected from alkyl groups of up to about 22 carbon atoms and aryl groups of up to about 22 carbon atoms and alkylene group of up to about 22 carbon atoms and an arylene group of up to about 22 carbon atoms. The alkyl, aryl and alkylene groups may be substituted or unsubstituted, branched or straight chains. In addition, R may contain heteroatoms and may be straight chained or branched.Compounds of formula I are useful as anti-bacterial and anti-viral in mammals in vivo and have been contemplated to be used in the treatment of skin disease.

A method of treatment or prophylaxis of herpes infections and associated disease states by administration of compositions comprising immunoglobulins. Methods comprising intravenous and topical administration of immunoglobulins are provided.

A therapeutic treatment device for treating colds sores and the like. The device includes a housing configured to be hand held, and having an annular pad at one end thereof configured to engage and area of the body of the user. A heat source is maintained adjacent the pad. A controller, in the form of a programmable chip or the like, allows for the heat source to be energized for a particular period of time, shutting off automatically. After a predetermined quiescent period of time has expired, the device signals the user that the heat source can be energized again, with the controller then maintaing the activation of the heat source for a second preselected period of time. The cycle continues until the treatment is complete. A treatment actuator communicates with the controller to enable the controller to process through the treatment sequence. The treatment activator may be specifically tailored to any of various treatments, including the treatment for a cold sore, an insect bite, a bee sting, a spider bite, or the like.

The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and / or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and / or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.

Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a gene corresponding to one of the open reading frames UL5, UL8, UL9, UL13, UL29, UL30, UL39, UL40, UL42 AND UL52 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site; it is also preferred that they comprise the sequence CAT. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide specifically hybridizable with RNA or DNA deriving from one of the foregoing genes of the herpesvirus are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.

The present invention discloses a microfluidic device for detection of five indicators of sound child rearing, the microfluidic device includes a microfluidic chip, a temperature control module, a micro motor moving module and a CCD detection module, through the mutual matching of the micro motor moving module, the temperature control module and the microfluidic chip, the processes of capture of target cell specific antigens and cleaning of cell antigens non-specifically adsorbed on microsphere surface by use of antibodies coating the microsphere surface, capture of enzyme labelled antibodies by use of the target cell antigens non-specifically adsorbed on the microsphere surface and catalytic chemiluminiscence of an excitation liquid by use of enzymes non-specifically adsorbed on the microsphere surface and the like can be respectively completed, the CCD detection module is cooperated for acquisition and detection of chemicalluminescence signals on the microsphere surface so as to achieve integration operation of the capture and detection process of five indicator antigens of sound child rearing in serum samples; the five indicators of sound child rearing comprise TOX (Toxoplasma gondii), RUB (Rubella), CMV (cytomegalovirus), HSV-1 (herpe-1), and HSV-2 (herpe-2).

A method treating diseases including cancer comprising administering a drug which provides interferon alpha once inside the body, administering a vaccine containing tumor necrosis factor, and administering a predetermined quantity of an anti-viral drug. The three drugs work together to strengthen the patient's immune system, make the infection or virus more vulnerable to attack by the immune system, and enabling the body to regenerate healthy cells and tissues damaged by the infection or disease. The foregoing treatment method is also effective in treating Type I diabetes, obesity, multiple sclerosis, interstitial cystitis, acquired immune deficiency syndrome, herpes simplex, and herpes zoster.

The invention relates to a traditional Chinese medicine extracting solution capable of resisting bacteria, removing acnes and treating blebs as well as application thereof and skin-care lotion prepared from the traditional Chinese medicine extracting solution and belongs to the technical field of cosmetics. The traditional Chinese medicine extracting solution is prepared from the following components: mulberry twig / or mulberry root extract, dandelion extract and chamomile extract; the extracting solution contains a plurality of types of active and effective components, can be used for effectively inhibiting or killing coryneform bacteria on surfaces of the acnes, and acne propionibacterium, staphylococcus epidermidis and malassezia fufur of pathogenic bacteria in the acnes, and has the effect of removing the acnes on faces and backs, thus treating both symptoms and root causes; meanwhile, bleb viruses are inhibited or killed, so that the skin-care lotion prepared from the traditional Chinese medicine extracting solution can be used for resisting the bacteria, removing the acnes and effectively inhibiting the bleb viruses; and the skin-care lotion has a good curative effect and a lasting effect, does not bounce and the like and has no skin irritation effect and other side effects.

Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment, inoculating a tumor in the patient with a pharmaceutical composition consisting essentially of (A) a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells and (B) a pharmaceutically acceptable vehicle for the virus, such that an immune response is induced that is specific for the tumor cell type and that kills cells of the inoculated tumor and of a non-inoculated tumor. In another embodiment, the pharmaceutical composition also comprises a defective HSV vector which contains an expressible nucleotide sequence encoding at least one immune modulator. In another embodiment, the pharmaceutical composition contains a second HSV that infects tumor cells but that does not spread in normal cells. According to the latter approach, both the first HSV and the second HSV may have genomes that comprise, respectively, an expressible nucleotide sequence coding for at least one immune modulator. In another embodiment, the pharmaceutical composition comprises, in addition to a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells, a viral vector comprising at least one expressible nucleotide sequence coding for at least one immune modulator.

Therapeutic compositions made from the herb Tribulus terrestris and methods of making and using the same are provided. The therapeutic compositions include an enriched extract having an increased spirostanol saponin content that is prepared from the harvested Tribulus terrestris L. The enriched extract is prepared using discrete hydrolysis, separation and enrichment steps. The resulting therapeutic may be combined with a cream base and is useful for treating bacterial, fungal, and viral infections, particularly gynecologic infections. This product was also found to be very successful in suppository form for the treatment of vulvo-vaginal, vulvo-hemorrhoidal and colonic conditions.

Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment, inoculating a tumor in the patient with a pharmaceutical composition consisting essentially of (A) a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells and (B) a pharmaceutically acceptable vehicle for the virus, such that an immune response is induced that is specific for the tumor cell type and that kills cells of the inoculated tumor and of a non-inoculated tumor. In another embodiment, the pharmaceutical composition also comprises a defective HSV vector which contains an expressible nucleotide sequence encoding at least one immune modulator. In another embodiment, the pharmaceutical composition contains a second HSV that infects tumor cells but that does not spread in normal cells. According to the latter approach, both the first HSV and the second HSV may have genomes that comprise, respectively, an expressible nucleotide sequence coding for at least one immune modulator. In another embodiment, the pharmaceutical composition comprises, in addition to a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells, a viral vector comprising at least one expressible nucleotide sequence coding for at least one immune modulator.

The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and / or cell-specific promoters to drive expression of the herpes γ34.5 gene.