41 results about "Daytime somnolence" patented technology

A once-a-day oral milnacipran modified release formulation has been developed. The formulation comprises an extended release dosage unit (optionally containing the immediate release portion) coated with delayed release coating. The milnacipran composition, when administered orally, first passes through the stomach releasing from zero to less than 10% of the total milnacipran dose and then enters the intestines where drug is released slowly over an extended period of time. The release profile is characterized by a 0.05-4 hours lag time period during which less than 10% of the total milnacipran dose is released followed by a slow or extended release of the remaining drug over a defined period of time. The composition provides in vivo drug plasma levels characterized by Tmax at 4-10 hours and an approximately linear drop-off thereafter and Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition allows milnacipran to be delivered over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

Dry powder formulations of drugs such as antihistamine for nasal administration are provided where the drug is retained in the nasal cavity, and systemic side effects minimized or eliminated, through the selection of a narrow particle size range, between approximately 10 and 20 microns in diameter. In a preferred embodiment wherein the drug is an antihistamine, retention of the antihistamine at the nasal mucosa is improved and the bitter aftertaste associated with liquid antihistamine formulations significantly reduced. By making a dry powder formulation of an antihistamine (e.g., azelastine) having an average particle size of between 10 and 20 microns, the antihistamine is restricted primarily to the desired target organ, the nasal mucosa. Because the active ingredient stays in the nasal region, a lower dose can be used to achieve the same desired effect. As demonstrated by the examples, this lower dose reduces the incidence of somnolence, and because the active ingredient remains at the target organ and does not accumulate in the back of the throat and mouth, this formulation does not impart a bitter taste.

Dry powder formulations of drugs such as antihistamine for nasal administration are provided where the drug is retained in the nasal cavity, and systemic side effects minimized or eliminated, through the selection of a narrow particle size range, between approximately 10 and 20 microns in diameter. In a preferred embodiment wherein the drug is an antihistamine, retention of the antihistamine at the nasal mucosa is improved and the bitter aftertaste associated with liquid antihistamine formulations significantly reduced. By making a dry powder formulation of an antihistamine (e.g., azelastine) having an average particle size of between 10 and 20 microns, the antihistamine is restricted primarily to the desired target organ, the nasal mucosa. Because the active ingredient stays in the nasal region, a lower dose can be used to achieve the same desired effect. As demonstrated by the examples, this lower dose reduces the incidence of somnolence, and because the active ingredient remains at the target organ and does not accumulate in the back of the throat and mouth, this formulation does not impart a bitter taste.

The invention provides a heart fire-clearing upset-relieving health-care tea, which is characterized by being prepared from the following materials: Chinese angelica, szechuan lovage rhizome, prepared rehmannia root, turmeric root-tuber, rhizoma zingiberis preparatum, red peony root, white paeony root, peach seed, carthamus, thinleaf milkwort root-bark, lotus leaf, semen nelumbinis, mix-fried licorice, Chinese date and ginkgo seed. The preparation method comprises the following steps: cleaning the raw materials; mixing the cleaned raw materials; adding water into the mixture; after boiling the mixture for 20 to 60 minutes, filtering to remove slag and obtaining the heart fire-clearing upset-relieving health-care tea. In the tea, the raw materials jointly exert effects of promoting qi circulation and removing obstruction in the collateral, clearing heart and inducing resuscitation, activating blood and dissolving stasis and warming inside and relieving pains, so the tea can treat sadness, palpitation due to fright, mind absence, somnolence, poor memory, stagnation of the liver-qi, and qi stagnation and blood stasis. The tea can be drunk directly after being boiled, has health-care function, and can relieve long-term depression, ease mind, and be used as a daily health-care product.

The present invention is directed to CNS pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a CNS active agent and preferably at least two vagal neuromodulators, one of which is a mechanoreceptor stimulator. The vagal neuromodulators are preferably in an amount sufficient to reduce a somnolence side-effect of the CNS active agent without changing its therapeutic efficacy / activity. The invention further encompasses a method of reducing CNS active agent side-effects. The method typically comprises oral administration of at least one CNS active agent to a patient at the conventionally accepted dose; and administration of at least two vagal neuromodulators to the patient so that at least one neuromodulator is administered or released from dosage form after the CNS active agent is administered and / or released.

The invention provides spleen-Qi-nourishing and dampness-removing particles containing effective traditional Chinese medicinal ingredients, and a preparation method thereof. The particles contain lotus leaf extracts, yam extracts, poria cocos extracts, burdock root extracts, eucommia ulmoides extracts, hawthorn extracts, semen coicis extracts, red bean extracts, red dates extracts, roasted malt extracts, soluble starch, sucrose, dextrin, distilled water and 75% ethyl alcohol. Compared with the prior art, the spleen-Qi-nourishing and dampness-removing particles contain multiple effective traditional Chinese medicinal ingredients, and can be used for nourishing Qi and spleen, removing dampness, resolving phlegm, conditioning a phlegm-damp type body, eliminating local edema, and improving symptoms of hyperhidrosis, profuse sputum, tiredness and somnolence caused by insufficiency of the spleen; the spleen is nourished whilst water dampness is removed.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating a damp-abundance spleen trapped type somnolence disease. The traditional Chinese medicine is prepared from 10-20 g of Chinese yams, 10-20 g of medcinal evodia fruit, 8-18 g of Chinese starjasmine stems, 8-18 g of fiveleaf gynostemma herb, 8-18 g of semen coicis, 8-18 g of gorgon euryale seeds, 8-18 g of radix stephaniae tetrandrae, 8-18 g of officinal magnolia bark, 8-18 g of rhizoma atractylodis macrocephalae, 8-18 g of prepared common monkshood daughter roots, 5-15 g of cortex erythrinae, 5-15 g of poria cocos, 5-15 g of heterophyllous wing seedtree roots, 5-15 g of paniculate swallowwort roots, 3-9 g of cocklebur fruit, 2-10 g of radix codonopsis, 2-10 g of java amomum fruit, 2-10 g of pericarpium citri reticulatae, 2-10 g of licorice roots, 2-10 g of cortex cinnamomi and 2-10 g of ginger. According to clinical experiments, the cure rate of the traditional Chinese medicine for treating the damp-abundance spleen trapped type somnolence disease is high than 96.92 percent and can reach up to 99.23 percent, the average cure rate is 98.15 percent, the total effective rate is 100 percent, and the traditional Chinese medicine is very suitable for treating the damp-abundance spleen trapped type somnolence disease. In addition, the traditional Chinese medicine is quick in efficacy, short in cure cycle, and the traditional Chinese medicine composition is prepared from pure traditional Chinese medicines and is free of toxic and side effects and free of concerns about the drug dependence.

An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

The invention relates to a traditional Chinese medicine for treating liver constraint and spleen deficiency type post-stroke depression. The traditional Chinese medicine has obvious treatment effects on symptoms such as deprementia, chest hypochondriac pain, lassitude, upset irritability, abdominal distension and diarrhea and the like of the liver constraint and spleen deficiency type post-strokedepression, improves spirit and emotions, promotes the recovery of neural functions of stroke patients, and does not have obvious toxic or side effects such as dizziness, hypodynamia, somnolence, drymouth, constipation, hypotension, abnormal liver functions, epilepsy, cardiac arrhythmia, toxicosis and the like. The technical scheme is that: the traditional Chinese medicine is prepared form the following raw materials by weight: 10 to 14g of bupleurum, 9 to 11g of turmeric root-tuber, 10 to 14g of Chinese angelica, 10 to 14g of white paeony root, 13.5 to 16.5g of fried largehead atractylodes rhizome, 9 to 11g of Indian buead, 18 to 22g of codonopsis pilosula, 9 to 11g of tangerine peel, 9 to 11g of bamboo shavings, 13.5 to 16.5g of gardenia, 4.5 to 5.5g of mint and 2.7 to 3.3g of liquoricroot. The traditional Chinese medicine is prepared into decoction by the conventional soaking, decocting and filtering or is prepared by directly blending market-sold single Chinese medicinal formulaparticles. The traditional Chinese medicine has the advantages of high reliability, high safety, high flexibility, no dependence and the like.