89 results about "Cerebral atrophy" patented technology

The invention relates to a stable preparation of phosphatidylserine and a preparation method, application as well as an application product of the stable preparation. The preparation method comprises the following step of processing the phosphatidylserine through microencapsulation, micro-pelletization or liposome encapsulation. The stable preparation of the phosphatidylserine can be independently applied as a medicine or can be added into daily foods, drinks and health-care products, also has an important effect on health care of brains while guaranteeing the color and the taste of the daily foods and the drinks of people and is of great benefit to brain disorder such as nutritional supplement of brain development of students, overstrain of nerves of the adults, and memory loss, brain atrophy and senile dementia of the middle aged and elderly people.

The invention belongs to the technical field of biological engineering, and relates to an NGF-Fc fusion protein and a preparation method thereof. The method comprises the following steps: constructing a human immune globulin IgG Fc and nerve growth factor (NGF) fusion gene expression vector through a genetic engineering means, transferring to a mammal cell to make the transferred mammal cell highly express and produce NGF-Fc fusion proteins, purifying, identifying and carrying out biological activity detection. The expression vector transferred mammal cell constructed in the invention can express bioactive NGF-Fc fusion proteins, so the expression level can be 150mg / L or above, and the obtained protein has good stability and long half life, and can be used to prepare drugs for treating Alzheimer's disease, diabetic peripheral neuropathy, Parkinson's disease, facial neuritis, craniocerebral trauma, trauma of spinal cord, acute cerebrovascular disease, encephalatrophy and other neurological diseases, and peripheral nerve injury acute cerebral vascular central nerve injuries induced by chemical drugs.

The invention relates to the computation technology field for brain shrinkage degree, and more particularly to a quantitative calculation method for automatic regional brain shrinkage degree. The quantitative calculation method comprises at least the steps of brain template library creating, non-linear registration mapping and brain shrinkage degree calculation. The quantitative calculation method is convenient, rapid and highly quantitative. With the method, it is possible to find a highly feasible scheme for quantitative brain shrinkage degree so as to provide reference to other judgments based on the brain shrinkage degree.

Disclosed herein are methods of treating a human patient afflicted with multiple sclerosis (MS) or presenting a clinically isolated syndrome (CIS), for treating a human subject by providing neuroprotection, and of treating a human patient afflicted with MS or presenting a CIS by increasing the time to confirmed disease progression and / or confirmed relapse or reducing brain atrophy, comprising orally administering a daily dose of about 1.2 mg laquinimod or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical oral unit dosage form of about 1.2 mg laquinimod or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier for use in treating a human patient afflicted with MS or presenting a CIS, in treating a human subject by providing neuroprotection, or in treating a human patient afflicted with MS or presenting a CIS by increasing the time to confirmed disease progression and / or confirmed relapse or reducing brain atrophy.

The invention discloses a brain CT / MR (Computed Tomography / Magnetic Resonance) image fusion method for improved coupled dictionary learning on the basis of sparse representation, relates to the technical field of image processing, and can independently carry out fusion on three groups of brain medical images including a normal brain, encephalatrophy and brain tumors. Multiple experiment results indicate that an ICDL (Improved Coupled Dictionary Learning) method which is put forward by the invention improves the fusion quality of brain medical images, effectively lowers time for dictionary training and can provide effective help for clinic medical diagnosis if being compared with a method based on multi-scale transformation, a traditional sparse representation method, a method based on K-SVD (K-Singular Value Decomposition) dictionary learning and a multi-scale dictionary learning method.

The invention discloses a moxa stick for improving brain health, which is characterized by comprising the following raw medicinal materials in parts by weight: 200 parts of folium artemisiae argyi, 1-5 parts of eaglewood, 5-15 parts of polygonum multiflorum, 1-5 parts of mulberry, 5-15 parts of dogwood, 10-20 parts of liquorice, 5-15 parts of sealwort, 4-8 parts of the bark of eucommia, and 4-8 parts of spina date seed. The invention further discloses a preparation method of the moxa stick. Because of being prepared by adding medicinal materials into folium artemisiae argyi, the moxa stick disclosed by the invention is safe, nontoxic and convenient to use, has the effects of stimulating the menstrual flow, activating collaterals, restoring consciousness, enlightening, reinforcing kidney, protecting liver, reducing internal heat and dispelling depression, is capable of improving brain health and preventing and treating brain diseases, and has good effects on a series of diseases caused by insufficient cerebral blood supply, such as cerebral infarction, cerebral arteriosclerosis, insufficient cerebral blood supply, infantile autism, depression and encephalatrophy; meanwhile, the moxa stick for improving brain health, which is disclosed by the invention, is capable of relieving emotion of people, reducing stress and improving sleep and has the obvious effect on psychiatric problems caused by tension and stress, such as schizophrenia.

The present invention discloses an Alzheimer's disease auxiliary therapeutic device utilizing high potential and ultrashort wave and belongs to the technical field of Alzheimer's disease therapy. TheAlzheimer's disease auxiliary therapeutic device utilizing the high potential and ultrashort wave comprises a high potential therapy mechanism, a left side of the high potential therapy mechanism is provided with a therapy chair, an upper end of the high potential therapy mechanism is fixedly connected with an operation console, the operation console is provided with a potential adjusting panel, and the potential adjusting panel is electrically connected with the operation console. The Alzheimer's disease auxiliary therapeutic device can realize combination of a high potential therapy with anultrashort wave therapy for the Alzheimer's disease therapy, improves a healing effect of Alzheimer's diseases, regulates signal transmission of neurons, and reduces and alleviates occurrence and development of brain atrophy. At the same time, a magnetic therapy reflection mechanism is arranged to speed up therapy efficiency of the adjuvant therapeutic device, reduces time spent on ultrashort wavetherapy for a long time, and thus reduces discomfort of patients during the therapy.

The invention discloses an intelligence improving device, which comprises a shell, a rolling sphere and a clamping tool, wherein the shell is at least provided with two cavities, one of the two cavities is a rolling sphere inlet, the other is a container for containing the rolling sphere, a rolling sphere outlet is arranged in the container, and the rolling sphere inlet and the rolling sphere outlet are communicated and connected via a connection conduit. The invention has the advantages of integrating intelligence benefiting and entertainment, practicing the flexibility of hands and brain and invigorating brain and benefiting intelligence for all ages, can develop the IQ of minors, exercises the attention and eyesight of the minors, can also be used for preventing and assisting the treatment of serious irreversible diseases such as poor balancing ability, senile dementia, brain atrophy and the like of the adults, and has the effects of improving memory and delaying aging and the like; the functions are complete, different game modes can be set to meet the requirements of different people; and the device has simple structure and low price and can be popularized and applied in each family.

To that end, in order to overcome some of the deficiencies presented herein above, an exemplary system, method and computer-accessible medium for determining an attribute(s) of a brain of a patient, can include, for example, receiving information obtained from a computed tomography (“CT”) scan(s) of a portion(s) of the brain, generating a CT image(s) that can be based on the information, and determining the attribute(s) of the brain based on the CT image(s) by segmenting an intracranial space (ICS) in the CT image(s). The attribute(s) can include a presence or absence of Alzheimer's disease, total volume of the ICS, brain, CSF or a lesion or the volumes of ICS, brain, CSF or lesion(s) expressed as a percentage of other volume(s). The aforementioned areas can be segmented using a combination of thresholding, morphological erosions, morphological dilations, manual segmentation or semi-automatic segmentation techniques, all of which can be parallel procedures. These attributes can be further used to determine treatment, for example, optimizing the location of the twist drill craniotomy to drain hematoma in subdural hematoma.

The invention discloses an externally-applied traditional Chinese medicine preparation for curing cardio-cerebral respiratory circulatory system diseases and a preparation method thereof. The externally-applied traditional Chinese medicine preparation is prepared by selecting 34 traditional Chinese medicines capable of promoting blood and qi circulation, removing obstruction in channels and dredging veins, such as spina gleditsiae, semen momordicae, safflower, and the like and can be made into three preparations, namely, paste, medicine bags and tablets. The medicine preparation has a unique prescription, adopts an external treatment method matched with a traditional Chinese medical acupuncture point theory to cure the cardio-cerebral respiratory circulatory system diseases, has remarkable curative effects on various diseases, such as coronary heart disease angina, psychosis, paroxysmal sleep, Parkinson's disease, epileptics, paroxysmal sleep, encephalatrophy, rhinitis, chronic pharyngitis, laryngitis, asthma, gynecologic diseases, child attention deficient disorder, child bed-wetting disease, and the like. In addition, the medicine preparation has the efficacy of promoting intelligence, restoring consciousness, improving the health and strengthening the body without side effect.

A Chinese medicine for treating hypertension, cerebral arteriosclerosis, cerebral infarction, cerebral thrombus, cerebral haemorrhage, and encaphalatrophy is prepared from 10 Chinese-medicinal materials including red peony root, peach kernel, saffron, black sesame, etc through drying in sum, pulverizing, sieving, baking, mixing, stirring and preparing honeyed pills.

The invention discloses an external Chinese medicinal composition for treating motor dysfunction and a preparation method thereof. Its raw materials include Chinese medicinal materials such as calamus calamus, maple lotus, ivy, windproof, and multiflorum multiflorum; compared with the prior art, the present invention has obvious characteristics in principles, methods, prescriptions, and medicines, and is mainly used for stroke (cerebral hemorrhage) , cerebral infarction, etc.) and brain atrophy caused by paralysis, limb numbness, muscle atrophy, motor dysfunction, etc. have preventive and therapeutic effects. The present invention adopts medicine for external use combined with massage therapy, and in the course of medication, adjusts medication according to the specific condition of the patient, so as to achieve the best therapeutic effect.

The invention relates to the technical field of medical apparatus equipment, in particular to an independent exercising rehabilitation apparatus with the physical therapy and baby-sitter functions anda using method thereof during the middle and later treatment and rehabilitation recovery periods in a neurology department. The physical therapy and walking exercising rehabilitation apparatus for patients suffering from stroke, brain obstruction, brain bleeding, brain atrophy, brain neural damage, leg myasthenia and long illness is obtained. The apparatus is an assembly which comprises an upperunit and a lower unit, the upper unit is used for free walking rehabilitation exercising and magnetic physical therapy and has the daily life baby-sitter function, a patient can be protected by a backauxiliary type safety belt to freely walk on a circular conveyor rubber belt. Passive searing, puncturing and stroking can be performed on foot sole acupoints, a reflecting region, micro-circulationblood vessels and a neural system, and magnetic physical therapy is performed by means of different means. The bottom layer lower unit is a walking platform, after assembling, the patient can freely move in living quarters such as a courtyard, a small square, a park and the like, the running speed of the lower unit is the same as that of the upper unit, and free walking, exercising, rehabilitatingand physical therapy are synchronized.

The invention belongs to the field of brewing, and relates to lipid-lowering and intestine-moistening health care vinegar and a preparation method thereof, wherein the health care vinegar is prepared from pseudo-ginseng, ginseng, fruit of Chinese wolfberry, haw, Fructus Ziziphi Jujubae, safflower, dried Radix Polygoni Multiflori, black beans, fructus rubi, mulberry, dried orange peel, walnut kernel and millet vinegar. On the basis of a secret prescription handed down from ancestors, the inventor, in combination with summary of clinical experiences for years, prepares the vinegar which can take a unique curative effect on intractable hyperlipidemia disease through repeated experiments; through scientific combination of various medicines and comprehensive medication, active ingredients of medicines can rapidly enter blood for circulation, so as to reduce blood cholesterol, block thrombosis, dilate coronary artery, increase blood flow volume, enhance tolerance of myocardial ischemia, improve cerebral infarction and repair damaged cranial nerve, therefore patients with hyperlipidemia disease can recover rapidly. The medicine disclosed by the invention can take a unique curative effect on hypertension, hyperlipidemia, constipation, encephalatrophy, cerebral thrombosis, coronary disease, cerebral arteriosclerosis and sequela of apoplexy; and the medicine has the advantages of being rapid to take effect, short in treatment course, high in cure rate and low in cost.

The invention discloses a brain volume atrophy prediction method based on a brain function network. The brain volume atrophy prediction method comprises the following steps: 1, processing function image data, analyzing the function data and calculating a brain volume; 2, establishing a brain function network; 3, calculating the average path length and the aggregation coefficient of the brain network; and 4, establishing a prediction model of brain volume atrophy. Through the steps, the brain volume atrophy prediction method establishes the mapping relation between the topological characteristics of the brain function network and the brain atrophy information, and provides the brain volume atrophy prediction method based on the brain function network. The brain volume atrophy prediction method has early warning, systematicness and robustness, and the research result of the brain volume atrophy prediction method can provide powerful method support for future prediction of brain volume atrophy, and can achieve early prevention and treatment of brain atrophy.

The invention relates to a traditional Chinese medicine preparation for treating senile dementia, encephalatrophy and dysgnosia. The traditional Chinese medicine preparation is prepared from the following substances in parts by weight: pilos antler, saffron crocus, astragalus membranaceus, herba cistanche, earthworms, turtle paste, hirudo, golden cypress, semen cuscutae, morinda officinalis, salvia miltiorrhiza, ligusticum wallichii, tail of Chinese angelica root, peach kernels, radix paeoniae rubra, dipsacaceae, radix achyranthis bidentatae, rhodiola rosea, polygala tenuifolia, radix angelicae, notoginseng, safflower carthamus, caulis spatholobi, rhizoma drynariae, epimedium and rehmannia glutinosa. According to the traditional Chinese medicine preparation, the cognition impairment can be improved, the cerebral atrophy can be delayed, the memory can be increased, and an obvious effect of preventing and treating the senile dementia is achieved.

A brain imaging system includes a first imaging device, a second imaging device, a third imaging device and a central processor. The first imaging device captures a first brain image, and calculates a cerebral blood flow, a cerebral blood volume, a cerebral blood mean transit time and a first contrast agent time to peak. The second imaging device captures a second brain image, and calculates the cerebral blood flow, the cerebral blood volume, the cerebral blood mean transit time and a second contrast agent time to peak. The central processor generates an image of a vessel occlusion, infarction or ischemia region respectively according to the vessel occlusion, infarction or ischemia regions in the first brain image and in the second brain image. The third imaging device obtains a brain atrophy region according to the cerebral cortex volume calculated by the third imaging device.

The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation agent for regulating high cholesterol. The medicine is prepared by parts from puer tea, lindera aggregate, cyperus rotundus, melon kwai, creat, fructus forsythia, hawksbill, radix asparagi, pollen typhae, pubescent holly root, gastrodia elata, and kelp. The present invention combines traditional remedy with conclusions from many years' clinical experiences, after repeated experiments to be prepared ready, therefore, the present medicine has unique remedy effect for refractory high cholesterol, it adopts multiple medicines scientifically proportioned, together with treatments enables the effective components of medicine to rapidly enter into blood circulation, lowers the blood cholesterol, prevents thrombus formation, enlarges coronary artery, increases blood flow, increases the endurance ability of blood muscle ischemia, improves cerebral infarction, repairs damaged brain nerves, enabling fast recovery of high blood lipid. The medicine has unique remedy effect for patients with high-blood pressure, high blood fat, diabetes, encephalatrophy, cerebral thrombosis, coronary heart disease, cerebral arteriosclerosis, sequela of apoplexy. The medicine has the advantages of being fast in taking effect, short in treatment period, high in recovery rate, and low in expenses.

The embodiment of the invention provides a method and device for identifying brain atrophy, and relates to the technical field of artificial intelligence, and the method comprises the steps: determining a key frame in a brain image sequence through employing a key frame detection module, detecting key points in the key frame through employing a key point detection module, and determining a first classification index according to the key points in the key frame; segmenting the key frame by adopting an image segmentation module, and determining a second classification index; identifying the brain atrophy according to the first classification index and the second classification index. Different detection modes are adopted according to the characteristics of different classification indexes, so that the detection precision of the classification indexes is improved; the first classification index and the second classification index are used for identifying the brain atrophy, and the accuracy of identifying the brain atrophy is also improved. Secondly, the neural network model is adopted to automatically identify the brain atrophy, and compared with manual measurement and calculation, the artificial dependence is small and the efficiency is high.

The invention relates to a medicinal preparation for treating cerebral palsy. The medicinal preparation provided by the invention has the function of benefiting brain and restoring mental clarity, is mainly used for treating cerebral palsy, amentia, hyperactivity, senile dementia and the like, and has remarkable effect in treating diseases caused by cerebral dysplasia, encephalatrophy and the like. The medicinal preparation is simple in preparation process, convenient in production processing, and definite in therapeutic effect.

The invention discloses application of a composition containing an MG 53 mutant in preparation of neuroprotective drugs. The research results prove that the MG53 mutant has a prominent neuroprotectiveeffect and can cross the blood-brain barrier, thus being applied to prevention or treatment of multiple neurodegenerative diseases such as ischemic stroke, brain atrophy, senile dementia, multiple system atrophy, brain atrophy, motor neuron diseases, ataxia telangiectasia, spinal muscular atrophy and optic atrophy.

The invention relates to a medical hat with functions of aroma resuscitation, expelling wind and removing dampness, promoting flow of qi and blood circulation, having refreshing effect on the mind and treating encephalatrophy diseases, and a manufacturing method thereof. The medical hat comprises a hat out layer (1) and a hat inner layer (2); and a functional layer (3) consisting of adsorptive aromatic medicine and crude fibers of substances for activating blood and dissolving stasis is arranged between the hat out layer (1) and the hat inner layer (2). The medical hat can keep warm, prevent and treat diseases, and avoids troubles that the old, in particular the old suffering the encephalatrophy diseases, always forget to take medicines, the taking dosage is not accurate, and the family needs to look after the old. The medical hat is suitable for various brain disease patients, in particular encephalatrophy patients.

The invention provides applications of N-acetyl-D-glucosamine in preparing medicines and health products for preventing and treating encephalatrophy and the medicines, belonging to the field of medicines. For the applications of N-acetyl-D-glucosamine in preparing the medicines for treating encephalatrophy and the applications of N-acetyl-D-glucosamine in preparing the health products aiming at encephalatrophy provided by the invention, the active ingredient, namely, N-acetyl-D-glucosamine can effectively treat or alleviate encephalatrophy, the treatment period is short, and no toxic and sideseffects exist. The active ingredients of the medicines used for treating encephalatrophy comprise N-acetyl-D-glucosamine, which can effectively treat or alleviate encephalatrophy, the treatment period is short, and no toxic and sides effects exist.

The invention relates to a traditional Chinese medicine for treating acute cerebral infarction. The traditional Chinese medicine is prepared from curcuma aromatic, raw pollen typhae, rhizoma corydalis, winged euonymus twig, snakegourd fruit, costusroot, coptis chinensis, schisandra chinensis, pubescent holly root, bile arisaema, panax notoginseng, gentiana macrophylla, radix codonopsis, dragon bone, semen plantaginis, red peony root, herba taxilli, rosa laevigata michx, fructus rubi and resina draconis. The traditional Chinese medicine is obtained by the inventor by combining with summaries of clinical experience over the years through repeated experiments on the basis of the secret prescription handed down from ancestors, so that the traditional Chinese medicine has a unique curative effect on an intractable 'cerebral infarction' disease; and the effective components of the medicine can rapidly enter blood circulation by scientific combination and comprehensive treatment of a plurality of medicines, so that blood cholesterol is reduced; thrombogenesis is blocked up; a coronary artery is expanded; the blood flow is increased; the tolerance of brain ischemia is improved; cerebral infarction is improved; damaged cranial nerves are repaired; and the 'cerebral infarction' disease can be rapidly cured. The traditional Chinese medicine has a unique curative effect on hypertension, hyperlipidemia, encephalanalosis, cerebral thrombosis, coronary heart diseases, cerebral arteriosclerosis and sequela of apoplexy, and has the advantages of being fast in acting, short in treatment course, high in recovery rate and low in cost.

The invention provides a traditional Chinese medicine composition used for delaying brain atrophy and a preparation method thereof. The traditional Chinese medicine composition is composed of the following components by mass percent: 5-7% of fructus lycii, 10-12% of longan pulp, 3-5% of alpiniae oxyphyllae fructus, 4-6% of polygonatum kingianum, 4-6% of spina date seeds, 10-12% of Chinese yam, 3-5% of raspberry, 10-12% of white lablab beans, 2-4% of cinnamon, 2-4% of dried ginger, 4-6% of oyster, 4-6% of walnuts, 4-6% of Chinese angelica, 4-6% of donkey-hide gelatin, 4-6% of mulberry, 4-6% of silkworm chrysalis and 4-6% of black sesame. The preparation method comprises the following steps: mixing the components, adding water, stewing into paste, then mixing with maltodextrin and potassium sorbate and granulating, drying, and sterilizing, so that the traditional Chinese medicine composition used for delaying the brain atrophy is obtained. The traditional Chinese medicine composition provided by the invention not only has the functions of warming the kidney and benefiting brain, promoting blood circulation and removing blood stasis, inducing resuscitation and regulating qi and blood and has a good effect of improving hemorheology of a patient suffering from the brain atrophy but also can provide nutrients for brain cells and promote regeneration of the brain cells.

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicament for treating encephalatrophy and facial paralysis. The medicinal composition is prepared from the following raw materials in parts by weight: 1-10 parts of ginseng, 1-10 parts of earthworm, 1-10 parts of leech and 1-10 parts of stiff silkworm, and is suitable for treating encephalatrophy, facial paralysis, muscle atrophy, neuratrophy, convulsion, joint pains, inhibited bending and stretching, cerebral apoplexy, epilepsy and other articular pains, is capable of stretching meridian and building bone, has a good drug effect, and does not have side effect.

The invention discloses a traditional Chinese medicine preparation for treating brain atrophy. The traditional Chinese medicine preparation consists of the following active pharmaceutical ingredients in parts by weight: 9-15 parts of flatstem milkvetch seed, 6-12 parts of fructus lycii, 6-12 parts of folium apocyni veneti, 9-15 parts of rhizoma polygonati, 2-9 parts of liquorice, 9-27 parts of radix acanthopanacis semticosi, 4-8 parts of fructus teminaliae billaricae, 6-15 parts of Chinese date, 6-12 parts of lily, 9-30 parts of aleppo avens, 6-12 parts of lucid ganoderma, 9-15 parts of longan pulp, 2-6 parts of semen nigellae, 3-10 parts of radix polygalae, 5-15 parts of herba merremiae and 3-10 parts of rhizoma acori graminei. The invention also discloses a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine composition for treating brain atrophy, disclosed by the invention, is a pure traditional Chinese medicine preparation which realizes a remarkable curative effect, avoids obvious toxic and side effect and has the advantages of high effect taking speed, exact curative effect, wide medicine source and low cost; and moreover, the effective rate is as high as 93%, the complication incidence is low, both symptoms and root causes are treated, and the long-term effect is good.

The invention discloses a Chinese medicinal preparation for treating encephalatrophy, which is prepared from the following raw materials in part by weight: 35 to 80 parts of fatsia japonica, 30 to 75 parts of arisaema inkiangense, 80 to 120 parts of astragalus, 30 to 75 parts of white paeony root, 20 to 70 parts of Chinese angelica, 15 to 65 parts of radix achyranthe bidentatae, 5 to 70 parts of tuber fleeceflower root, 20 to 70 parts of earthworm and 10 to 40 parts of ground beetle. The Chinese medicinal preparation for treating the encephalatrophy has the effects of tonifying liver and kidney, reinforcing vital energy, regulating Yin-Yang, dilating blood vessels, improving blood supply, recovering elasticity of blood vessels of brain, improving blood circulation and recovering functions of atrophic brain cells. Generally, the capsule has 100 percent of effective rate and 92 percent of cure rate within 60 days after being taken by patients with the encephalatrophy.

The invention discloses a traditional Chinese medicinal composition for treating headaches. The traditional Chinese medicinal composition comprises, by weight, 150-250 parts of rhizoma gastrodiae, 250-350 parts of pseudo-ginseng, 150-250 parts of fired stiff silkworms, 80-120 parts of glossy ganoderma and 250-350 parts of sealwort steamed with wine. The traditional Chinese medicinal composition is mainly used for treating headaches, dizziness, insomnia, cerebral infarction, encephalatrophy and apoplexy sequelae, which are caused by heart and cerebral vessel sclerosis, brain vasoconstriction and cerebral artery flow rate change, and can be also used for treating cerebral trauma sequelae.